Protein Alignment wit and Amhr2

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_112260.1
• Gene: Amhr2 / 29530
• RGDID: 70964
• Length: 557
• Species: Rattus norvegicus
• Alignment Length: 590
• Identity: 180/590 - (30%)
• Similarity: 265/590 - (44%)
• Gaps: 101/590 - (17%)

  Fly     3 WAIYLLLALISLGRATPVPNRQYSCMSYQEDDNSFHDDDGDQDSSGELQEQQVESTPIPSEPHRR 67
            |.:....|.:|       |||: :|:        |.:..|.:.|:..|.| .|::.|.|
  Rat     8 WTLLPAAAQVS-------PNRR-TCV--------FFEAPGVRGSTKTLGE-VVDAGPGP------ 49

  Fly    68 TCPDG----YTF-CFTIWNQTANGARVVKQGCWKDNTDRTSICSQSEC--TSSAPTSKTSSLYYC 125
              |.|    |:. ||.|||.|...|:|..|||.  ::|... |....|  ...|..|.:|:|:.|
  Rat    50 --PKGIRCLYSHCCFGIWNLTHGRAQVEMQGCL--DSDEPG-CESLHCDPVPRAHPSPSSTLFTC 109

  Fly   126 CCSGGVCNAQYSVVEPAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALTIGIFLAV 190
            .|....|||.||.:.|:     .|.|...............::|..:||:.  |..|...|.||:
  Rat   110 SCGTDFCNANYSHLPPS-----GNRGAPGPQEPQATPGGPIWMAQLLLGVF--LVLLLSIIILAL 167

  Fly   191 ---QYCRT-AKEKPEPEESPLAPSGPGYSSNLRNVDNMNLIGMLGSGKYGTVMKGLLHDQEVAVK 251
               :.||. ....||||..    ||...|..|..:..:....::..|.:..|..|.|..:.||:|
  Rat   168 LQRKACRVQGGSDPEPEPG----SGGDCSEELPELAELRFSQVIQEGGHAVVWAGRLQGEMVAIK 228

  Fly   252 IYPEEHHQYYVNERNIYAL--------------------PLMECPALLSYFGYDERCTMDGRMEY 296
            .:|......:..||.:|.|                    ||...|.
  Rat   229 AFPPRAVAQFRAERAVYQLLGLQHNHIVRFITAGQGGPGPLPSGPL------------------- 274

  Fly   297 QLVLSLAPLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTRNVL 361
             |||.|.|.|.|..:|...|..:.....|..|:..|::.||.|.....|:||.:||||::::|||
  Rat   275 -LVLELYPKGSLCHYLTQYTSDWGSSLRMALSLAEGLAFLHGERWQDGQYKPGIAHRDLSSQNVL 338

  Fly   362 VQADLSCCIADFGFALKVFGSKYEYKGEVAMAETK-----SINEVGTLRYMAPELLEGAVNLRDC 421
            ::.|.||.|.|.|.||.:.|    .....|:|.|:     :|.|.||.||||||||:..::|:|.
  Rat   339 IREDRSCAIGDLGLALVLPG----LAQPPALAPTQPRGPAAILEAGTQRYMAPELLDKTLDLQDW 399

  Fly   422 ETSLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPL 486
            .|:|::.|||:|.|:|||:.:||||. .|....||::..||.|:||:||..::.||.|..:.||.
  Rat   400 GTALQRADVYSLALLLWEILSRCSDL-RPDHRPPPFQLAYEAELGSNPSACELWALAVAERKRPN 463

  Fly   487 FPTGWGGGAA-AKVVRDTCEDCWDHDADARLTSLCAEERMQEMSTLRPRAQAQPSSPLLNTNNLV 550
            .|:.|...|. .:.:|:..|||||.|.:||||:.|.::|:..::..:..:....|.|.....|..
  Rat   464 IPSSWSCSATDPRGLRELLEDCWDADPEARLTAECVQQRLAALAYPQVASSFPESCPQGCPENCP 528

  Fly   551 ASPTA 555
            |:|.:
  Rat   529 AAPAS 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	36/119 (30%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	111/325 (34%)
Amhr2	NP_112260.1	TFP_LU_ECD_AMHR2	22..121	CDD:467136	35/119 (29%)
		Protein Kinases, catalytic domain	205..506	CDD:473864	111/325 (34%)