DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wit and Amhr2

DIOPT Version :9

Sequence 1:	NP_001261395.1	Gene:	wit / 44096	FlyBaseID:	FBgn0024179	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_112260.1	Gene:	Amhr2 / 29530	RGDID:	70964	Length:	557	Species:	Rattus norvegicus

Alignment Length:	590	Identity:	180/590 - (30%)
Similarity:	265/590 - (44%)	Gaps:	101/590 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WAIYLLLALISLGRATPVPNRQYSCMSYQEDDNSFHDDDGDQDSSGELQEQQVESTPIPSEPHRR 67
            |.:....|.:|       |||: :|:        |.:..|.:.|:..|.| .|::.|.|
  Rat     8 WTLLPAAAQVS-------PNRR-TCV--------FFEAPGVRGSTKTLGE-VVDAGPGP------ 49

  Fly    68 TCPDG----YTF-CFTIWNQTANGARVVKQGCWKDNTDRTSICSQSEC--TSSAPTSKTSSLYYC 125
              |.|    |:. ||.|||.|...|:|..|||.  ::|... |....|  ...|..|.:|:|:.|
  Rat    50 --PKGIRCLYSHCCFGIWNLTHGRAQVEMQGCL--DSDEPG-CESLHCDPVPRAHPSPSSTLFTC 109

  Fly   126 CCSGGVCNAQYSVVEPAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALTIGIFLAV 190
            .|....|||.||.:.|:     .|.|...............::|..:||:.  |..|...|.||:
  Rat   110 SCGTDFCNANYSHLPPS-----GNRGAPGPQEPQATPGGPIWMAQLLLGVF--LVLLLSIIILAL 167

  Fly   191 ---QYCRT-AKEKPEPEESPLAPSGPGYSSNLRNVDNMNLIGMLGSGKYGTVMKGLLHDQEVAVK 251
               :.||. ....||||..    ||...|..|..:..:....::..|.:..|..|.|..:.||:|
  Rat   168 LQRKACRVQGGSDPEPEPG----SGGDCSEELPELAELRFSQVIQEGGHAVVWAGRLQGEMVAIK 228

  Fly   252 IYPEEHHQYYVNERNIYAL--------------------PLMECPALLSYFGYDERCTMDGRMEY 296
            .:|......:..||.:|.|                    ||...|.
  Rat   229 AFPPRAVAQFRAERAVYQLLGLQHNHIVRFITAGQGGPGPLPSGPL------------------- 274

  Fly   297 QLVLSLAPLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTRNVL 361
             |||.|.|.|.|..:|...|..:.....|..|:..|::.||.|.....|:||.:||||::::|||
  Rat   275 -LVLELYPKGSLCHYLTQYTSDWGSSLRMALSLAEGLAFLHGERWQDGQYKPGIAHRDLSSQNVL 338

  Fly   362 VQADLSCCIADFGFALKVFGSKYEYKGEVAMAETK-----SINEVGTLRYMAPELLEGAVNLRDC 421
            ::.|.||.|.|.|.||.:.|    .....|:|.|:     :|.|.||.||||||||:..::|:|.
  Rat   339 IREDRSCAIGDLGLALVLPG----LAQPPALAPTQPRGPAAILEAGTQRYMAPELLDKTLDLQDW 399

  Fly   422 ETSLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPL 486
            .|:|::.|||:|.|:|||:.:||||. .|....||::..||.|:||:||..::.||.|..:.||.
  Rat   400 GTALQRADVYSLALLLWEILSRCSDL-RPDHRPPPFQLAYEAELGSNPSACELWALAVAERKRPN 463

  Fly   487 FPTGWGGGAA-AKVVRDTCEDCWDHDADARLTSLCAEERMQEMSTLRPRAQAQPSSPLLNTNNLV 550
            .|:.|...|. .:.:|:..|||||.|.:||||:.|.::|:..::..:..:....|.|.....|..
  Rat   464 IPSSWSCSATDPRGLRELLEDCWDADPEARLTAECVQQRLAALAYPQVASSFPESCPQGCPENCP 528

  Fly   551 ASPTA 555
            |:|.:
  Rat   529 AAPAS 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	snake_toxin	57..133	CDD:264434	25/82 (30%)
		STYKc	226..517	CDD:214568	107/316 (34%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	111/325 (34%)
Amhr2	NP_112260.1	Activin_recp	<61..119	CDD:395845	22/60 (37%)
Amhr2	NP_112260.1	PKc_like	205..506	CDD:419665	111/325 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338290
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750