Protein Alignment wit and AMHR2

DIOPT Version :9

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_011536475.1
• Gene: AMHR2 / 269
• HGNCID: 465
• Length: 593
• Species: Homo sapiens
• Alignment Length: 571
• Identity: 178/571 - (31%)
• Similarity: 270/571 - (47%)
• Gaps: 77/571 - (13%)

  Fly     8 LLALISLGRATPVPNRQYSCMSYQEDDNSFHDDDGDQDSSGELQEQQVESTPIPSEPHRRTCPDG 72
            |.||:......| |||: :|:        |.:..|.:.|:..|.|.....|.:|     |.....
Human     7 LWALLPTAVEAP-PNRR-TCV--------FFEAPGVRGSTKTLGELLDTGTELP-----RAIRCL 56

  Fly    73 YT-FCFTIWNQTANGARVVKQGCWKDNTDRTSICSQSECTSS--APTSKTSSLYYCCCSGGVCNA 134
            |: .||.|||.|.:.|:|..||| :|:.:..  |....|..|  |..|..|:|:.|.|....|||
Human    57 YSRCCFGIWNLTQDRAQVEMQGC-RDSDEPG--CESLHCDPSPRAHPSPGSTLFTCSCGTDFCNA 118

  Fly   135 QYSVVEP--APLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALTIGIFLAVQYCRTAK 197
            .||.:.|  :|...|| :|..:....:.      ::|..:|||...|..|...|.||:...:..:
Human   119 NYSHLPPPGSPGTPGS-QGPQAAPGESI------WMALVLLGLFLLLLLLLGSIILALLQRKNYR 176

  Fly   198 EKPEPEESPLAPSGPGYSSNLRNVDNMNLI-GMLGSGKYGTVMKGLLHDQEVAVKIYPEEHHQYY 261
            .:.||...|...||..:|..|:.:..:... .::..|.:..|..|.|..:.||:|.:|......:
Human   177 VRGEPVPEPRPDSGRDWSVELQELPELCFSQQVIREGGHAVVWAGQLQGKLVAIKAFPPRSVAQF 241

  Fly   262 VNERNIYALP--------------------LMECPAL-LSYFGYDERCTMD-GRMEYQLVLSLAP 304
            ..||.:|.||                    |:..|.| |.....|..|... ||..:.   ||.|
Human   242 QAERALYELPGLQHDHIVRFITASRGGPGRLLSGPLLVLELHPKDCVCLCPRGRAPHN---SLCP 303

  Fly   305 LGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTRNVLVQADLSCC 369
            :|.|..:|...|..:.....|..|:.:|::.||.|.....|:||.:||||::::|||::.|.||.
Human   304 IGSLCHYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQNGQYKPGIAHRDLSSQNVLIREDGSCA 368

  Fly   370 IADFGFALKVFG-------SKYEYKGEVAMAETKSINEVGTLRYMAPELLEGAVNLRDCETSLKQ 427
            |.|.|.||.:.|       :..:.:|..|      |.|.||.||||||||:..::|:|...:|::
Human   369 IGDLGLALVLPGLTQPPAWTPTQPQGPAA------IMEAGTQRYMAPELLDKTLDLQDWGMALRR 427

  Fly   428 MDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGWG 492
            .|:|:|.|:|||:.:||.|. .|..:.||::..||.|:|:.|:.|::.||.|:.:.||..|:.|.
Human   428 ADIYSLALLLWEILSRCPDL-RPDSSPPPFQLAYEAELGNTPTSDELWALAVQERRRPYIPSTWR 491

  Fly   493 GGAA-AKVVRDTCEDCWDHDADARLTSLCAEERMQEMSTLRPRAQAQPSSP 542
            ..|. ...:|:..|||||.|.:||||:.|.::|:..:      |..|.|.|
Human   492 CFATDPDGLRELLEDCWDADPEARLTAECVQQRLAAL------AHPQESHP 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	snake_toxin	57..133	CDD:264434	25/78 (32%)
		STYKc	226..517	CDD:214568	106/321 (33%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	110/329 (33%)
AMHR2	XP_011536475.1	Pkinase	208..531	CDD:278497	111/338 (33%)
		PKc_like	208..528	CDD:304357	110/329 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820