Protein Alignment wit and Acvr2b

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_038936802.1
• Gene: Acvr2b / 25366
• RGDID: 2028
• Length: 545
• Species: Rattus norvegicus
• Alignment Length: 517
• Identity: 162/517 - (31%)
• Similarity: 262/517 - (50%)
• Gaps: 88/517 - (17%)

  Fly    76 CFTIWNQTANGARVVKQGCWKDNTDRTSIC-SQSECTSSAPTSKTSSLYYCCCSGGVCNAQYS-V 138
            |:..|..::....:||:|||.|:.:    | .:.||.:   |.:...:|:|||.|..||.::: :
  Rat    68 CYASWRNSSGTIELVKKGCWLDDFN----CYDRQECVA---TEENPQVYFCCCEGNFCNERFTHL 125

  Fly   139 VEPAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALTIGIFL--------------- 188
            .||...|:......|:.|       ..:.||.::|.: |||:.:.:..|.
  Rat   126 PEPGGPEVTYEPPPTAPT-------LLTVLAYSLLPI-GGLSLIVLLAFWMYRHRKPPYGHVDIH 182

  Fly   189 AVQYCRTA----------------KEKPEPEESPLAPSGPGYSSNLRNVDNMNLIGMLGSGKYGT 237
            .|:.|:..                ::...|..|||....|           :.|:.:...|::|.
  Rat   183 EVRQCQRGGGGRDGCADSFKLLLFQDPGPPPPSPLVGLKP-----------LQLLEIKARGRFGC 236

  Fly   238 VMKGLLHDQEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGRMEYQLVLSL 302
            |.|..|.:..|||||:|.:..|.:.:||.|::.|.|:...||.:...::|.: :..:|..|:.:.
  Rat   237 VWKAQLMNDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGS-NLEVELWLITAF 300

  Fly   303 APLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELR--LGDQHKPCVAHRDINTRNVLVQAD 365
            ...|.|.|:|..|.:|::|.|.:..:::||:|:||.::.  .|:.|||.:||||..::|||:::|
  Rat   301 HDKGSLTDYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSD 365

  Fly   366 LSCCIADFGFALKVFGSKYEYKGEVAMAETKSINEVGTLRYMAPELLEGAVNL-RDCETSLKQMD 429
            |:..:||||.|::.         |.......:..:|||.||||||:||||:|. ||   :..::|
  Rat   366 LTAVLADFGLAVRF---------EPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRD---AFLRID 418

  Fly   430 VYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGW--G 492
            :||:||||||:.:||.....|   ...|..|:|:|:|.|||.:::|.:||..|.||.....|  .
  Rat   419 MYAMGLVLWELVSRCKAADGP---VDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKH 480

  Fly   493 GGAAAKVVRDTCEDCWDHDADARLTSLCAEERMQEMSTLRPRAQAQPSSPLLNTNNLVASPT 554
            .|.|...|  |.|:||||||:|||::.|.|||   :|.:|....:..|..|:   :||.|.|
  Rat   481 PGLAQLCV--TIEECWDHDAEARLSAGCVEER---VSLIRRSVNSSTSDCLV---SLVTSVT 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	19/63 (30%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	115/304 (38%)
Acvr2b	XP_038936802.1	TFP_LU_ECD_ACVR2B	35..125	CDD:467152	19/63 (30%)
		STKc_ACVR2b	227..517	CDD:271042	117/310 (38%)