Protein Alignment wit and Acvrl1

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_071886.1
• Gene: Acvrl1 / 25237
• RGDID: 2029
• Length: 504
• Species: Rattus norvegicus
• Alignment Length: 521
• Identity: 144/521 - (27%)
• Similarity: 215/521 - (41%)
• Gaps: 81/521 - (15%)

  Fly    42 GD--QDSSGELQEQQVESTPIPSEPH--RRTCPDGYTFCFTIWNQTANGARVVKQGCWKDNTDRT 102
            ||  :.|.|:|.....|:      ||  |..|...:  |..:..:.......|.:||...|
  Rat    22 GDLVKPSRGQLVNCTCEN------PHCKRPICQGAW--CTVVLVREQGRHPQVYRGCGSLN---- 74

  Fly   103 SICSQSECTSSAPTSKTSSLYYCCCSGGVCNAQYSVV---------EP-----APLELGS----- 148
                |..|..    ..|..:.:.||....||...|::         ||     .||.||.
  Rat    75 ----QELCLG----RPTEFVNHHCCYRSFCNHNVSLMLEATQTPSEEPEVDAHLPLILGPVLALL 131

  Fly   149 ---NEGRTSI--TNRATEKQ---HQSFLASTMLGLAGGLTALTIGIFLAVQYCRTAKEKPEPEES 205
               ..|...:  ..|..|||   |.....|:::..|.......:|.|| |..|.|.
  Rat   132 VLVALGTLGLWRVRRRQEKQRGLHSDLGESSLILKASEQGDSMLGDFL-VSDCTTG--------- 186

  Fly   206 PLAPSGPGYSSNLRN--VDNMNLIGMLGSGKYGTVMKGLLHDQEVAVKIYPEEHHQYYVNERNIY 268
                ||.|....::.  ...:.|:..:|.|:||.|.:|..|.:.|||||:.....|.:..|..||
  Rat   187 ----SGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIY 247

  Fly   269 ALPLMECPALLSYFGYDERCTMDGRMEYQLVLSLAPLGCLQDWLIANTLTFSECCGMLRSITRGI 333
            ...|:....:|.:...| ..:.:...:..|:......|.|.|:|...||.......:..|...|:
  Rat   248 NTVLLRHDNILGFIASD-MTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGL 311

  Fly   334 SHLHTELRLGDQHKPCVAHRDINTRNVLVQADLSCCIADFGFALKVFGSKYEYKGEVAMAETKSI 398
            :|||.|: .|.|.||.:||||:.:|||||:::|.|||||.|.|: :.....:|      .:..:.
  Rat   312 AHLHVEI-FGTQGKPAIAHRDLKSRNVLVKSNLQCCIADLGLAV-MHSQSSDY------LDIGNN 368

  Fly   399 NEVGTLRYMAPELLEGAVNLRDCETSLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQ 463
            ..|||.||||||:|:..:. .||..|.|..|::|.||||||:|.|.    ........|:.|:..
  Rat   369 PRVGTKRYMAPEVLDEQIR-TDCFESYKWTDIWAFGLVLWEIARRT----IINGIVEDYRPPFYD 428

  Fly   464 EVGSHPSFDQMQALVVRHKARPLFPTGWGGGAAAKVVRDTCEDCWDHDADARLTSLCAEERMQEM 528
            .|.:.|||:.|:.:|...:..|..|...........:.....:||..:..||||:|..::.:|::
  Rat   429 MVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKL 493

  Fly   529 S 529
            |
  Rat   494 S 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	22/99 (22%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	96/299 (32%)
Acvrl1	NP_071886.1	TFP_LU_ECD_ALK1	30..99	CDD:467064	19/88 (22%)
		Mediates specificity for BMP ligand. /evidence=ECO:0000250	74..77		2/10 (20%)
		TGF_beta_GS	175..201	CDD:462503	9/39 (23%)
		STKc_ACVR1_ALK1	197..494	CDD:271044	97/310 (31%)