Protein Alignment wit and Tgfbr2

DIOPT Version :9

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_033397.3
• Gene: Tgfbr2 / 21813
• MGIID: 98729
• Length: 592
• Species: Mus musculus
• Alignment Length: 586
• Identity: 155/586 - (26%)
• Similarity: 248/586 - (42%)
• Gaps: 143/586 - (24%)

  Fly    22 NRQYSCMSYQEDDNSFHDDDGDQDSSGELQEQQVESTPIPSEPHRRTCPDGYTFCFTIWNQTANG 86
            :.|.||||                        ....|.|..:||.        .|..:|.:.
Mouse    87 DNQKSCMS------------------------NCSITAICEKPHE--------VCVAVWRKN--- 116

  Fly    87 ARVVKQGCWKDNTDRTSIC---------------SQSECTSSAPTSKTSSLYYCCCSGGVCNAQY 136
                     ..|....::|               :..:|..........:.:.|.|:...|| .|
Mouse   117 ---------DKNITLETVCHDPKLTYHGFTLEDAASPKCVMKEKKRAGETFFMCACNMEECN-DY 171

  Fly   137 SVVEPAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALTIGIFLAV---QYC----R 194
            .:.        |.|..||..:          |...::.:.|......:||.:||   .||    |
Mouse   172 IIF--------SEEYTTSSPD----------LLLVIIQVTGVSLLPPLGIAIAVIIIFYCYRVHR 218

  Fly   195 TAKEKPEPEESP--------------LAPSGPGYSSNLRNVDNMN-------LIGMLGSGKYGTV 238
            ..|..|..|.|.              |.......||...|..|.|       |..::|.|::..|
Mouse   219 QQKLSPSWESSKPRKLMDFSDNCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEV 283

  Fly   239 MKGLLHD------QEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGRMEYQ 297
            .|..|..      :.|||||:|.|.:..:..|::|::...::...:|.:...:||.|..|: :|.
Mouse   284 YKAKLKQNTSEQFETVAVKIFPYEEYSSWKTEKDIFSDINLKHENILQFLTAEERKTELGK-QYW 347

  Fly   298 LVLSLAPLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPC------VAHRDIN 356
            |:.:....|.||::|..:.:::.:...:..|:.|||:|||::      |.||      :.|||:.
Mouse   348 LITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSD------HTPCGRPKMPIVHRDLK 406

  Fly   357 TRNVLVQADLSCCIADFGFALKVFGSKYEYKGEVAMAETKSINEVGTLRYMAPELLEGAVNLRDC 421
            :.|:||:.||:||:.|||.:|::       ...:::.:..:..:|||.||||||:||..:||.:.
Mouse   407 SSNILVKNDLTCCLCDFGLSLRL-------DPTLSVDDLANSGQVGTARYMAPEVLESRMNLENV 464

  Fly   422 ETSLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPL 486
            | |.||.|||::.|||||:.:||:   |.|: ...|:.|:..:|..||..:.|:..|:|.:.||.
Mouse   465 E-SFKQTDVYSMALVLWEMTSRCN---AVGE-VKDYEPPFGSKVREHPCVESMKDSVLRDRGRPE 524

  Fly   487 FPTGWGGGAAAKVVRDTCEDCWDHDADARLTSLCAEERMQEM---STLRPRAQAQ---PSSPLLN 545
            .|:.|......::|.:|..:|||||.:||||:.|..||..|:   ..|..|:.:|   |....||
Mouse   525 IPSFWLNHQGIQIVCETLTECWDHDPEARLTAQCVAERFSELEHPERLSGRSCSQEKIPEDGSLN 589

  Fly   546 T 546
            |
Mouse   590 T 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	snake_toxin	57..133	CDD:264434	11/90 (12%)
		STYKc	226..517	CDD:214568	100/302 (33%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	104/311 (33%)
Tgfbr2	NP_033397.3	ecTbetaR2	74..177	CDD:286061	20/142 (14%)
		STYKc	269..566	CDD:214568	105/315 (33%)
		STKc_TGFbR2_like	273..567	CDD:270957	105/312 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	570..592		7/21 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810