DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wit and Bmpr2

DIOPT Version :9

Sequence 1:	NP_001261395.1	Gene:	wit / 44096	FlyBaseID:	FBgn0024179	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	XP_006245013.1	Gene:	Bmpr2 / 140590	RGDID:	71082	Length:	1052	Species:	Rattus norvegicus

Alignment Length:	1043	Identity:	304/1043 - (29%)
Similarity:	454/1043 - (43%)	Gaps:	231/1043 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 WAIYL------LLALISLGRA--TPVPNRQYSCM---SYQEDDNSFHDDDGDQDSSGELQEQQVE 56
            ||:.|      ||.::||.||  |...|::..|.   .||:|                   ..:.
  Rat    16 WAVLLVSTTAELLNILSLQRAGITASQNQERLCAFKDPYQQD-------------------LGIG 61

  Fly    57 STPIPSEPHRRTCPDGYTFCFTIWNQTANGARVVKQGCWKDNTDRTSICSQSEC--TSSAPTSKT 119
            .:.|..|.....|..|.| |:.:|.::.....:||||||....|... |...||  |::.|:.:.
  Rat    62 ESRISHENGTILCSKGST-CYGLWEKSKGDINLVKQGCWSHIGDPQE-CHYEECVVTTTPPSIQN 124

  Fly   120 SSLYYCCCSGGVCNAQYSVVEPAPLEL------GSNEGRTSITNRATEKQHQSFLASTMLGLAGG 178
            .:..:||||..:||..::...|.|...      .||...|.|...|:    .|.||..::.|..|
  Rat   125 GTYRFCCCSTDLCNVNFTENFPPPDTTPLSPPHSSNRDETIIIALAS----VSVLAVLIVALCFG 185

  Fly   179 LTALT----IGIFLAVQYCRTAKEKPEPEESPLAPSGPGYSSNLRNVDNMNLIGMLGSGKYGTVM 239
            ...||    .|:. :|.....|..:|.                 .::||:.|:.::|.|:||.|.
  Rat   186 YRMLTGDRKQGLH-SVSMMEAAAAEPS-----------------LDLDNLKLLELIGRGRYGAVY 232

  Fly   240 KGLLHDQEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGRMEYQLVLSLAP 304
            ||.|.::.||||::...:.|.::||:|||.:||||...:..:...|||.|.||||||.||:...|
  Rat   233 KGSLDERPVAVKVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERLTADGRMEYLLVMEYYP 297

  Fly   305 LGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTRNVLVQADLSCC 369
            .|.|..:|..:|..:...|.:..|:|||:::|||||..||.:||.::|||:|:|||||:...:|.
  Rat   298 NGSLCKYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNGGTCV 362

  Fly   370 IADFGFALKVFGSKYEYKGEVAMAETKSINEVGTLRYMAPELLEGAVNLRDCETSLKQMDVYALG 434
            |:|||.::::.|::....||   .:..:|:||||:||||||:|||||||||||::|||:|:||||
  Rat   363 ISDFGLSMRLTGNRLVRPGE---EDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALG 424

  Fly   435 LVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGW-GGGAAAK 498
            |:.|||..||:|.: ||::.|.|:..::.|||:||:|:.||.||.|.|.||.||..| ....|.:
  Rat   425 LIYWEVFMRCTDLF-PGESVPDYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVR 488

  Fly   499 VVRDTCEDCWDHDADARLTSLCAEERMQEM-----------STLRPRAQAQPSSPLLNTNNLV-- 550
            .:::|.|||||.||:||||:.||||||.|:           .|:.|.:.|..:...|:.|..|
  Rat   489 SLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPK 553

  Fly   551 --------ASPTAEQGINIIATTTTAAAVHHQMSSDTTGLIQPPPNQQIPLAALEREKNHLSYPQ 607
                    :|...|..|:...:.....:..|.|||             .||...|:.:|.::|.:
  Rat   554 IGPYPDYSSSSYIEDSIHHTDSIVKNISSEHSMSS-------------TPLTIGEKNRNSINYER 605

  Fly   608 QQLQ-------------------------------------PYQGRNPCQERNLAPLTMRTP--- 632
            ||.|                                     ||.........|:|.....||
  Rat   606 QQAQARIPSPETSVTSLSTNTTTTNTSGLTPSTGMTTISEMPYPDETHLHATNVAQSLGPTPVCL 670

  Fly   633 -------------PVLVERSKKHSFQTQPQENSLSCLEHDVSVEELIASHQHQQQKNTIVSTG-- 682
                         |..|:::.|.|......|:||........:....:|..:...|..:..||
  Rat   671 QLTEEDLETNKLDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEVTGQQ 735

  Fly   683 -----GNGNSCL------GQGF--PKQQN-----TDQKLRGWHGVRALIHKKLFRKEHAEELCRQ 729
                 .||.:||      .|.:  |||||     |...|...:..:.  .:..|..:|...| :|
  Rat   736 DFTQAANGQACLIPDVPPAQLYPLPKQQNLPKRPTSLPLNTKNSTKE--PRLKFGNKHKSNL-KQ 797

  Fly   730 LQLGEEKSNLVTALR-------------RPNNLDLNPRLDKPPPDQLRSAEQRMGTPAHIVPRSL 781
            ::.|..|.|.:.|..             |.:|::     ......|..:.....|..|:||....
  Rat   798 VETGVAKMNTINAAEPHVVTVTMNGVAGRSHNVN-----SHAATTQYANGVVPSGQAANIVAHRA 857

  Fly   782 SSSLIKHINGTTNNNSIQSHGSELQTLTRPASKRRPGHLRTNSLMATTGQGPPTEQQMRRQHSLE 846
            ...|....||.....:|.|...|.:.|.|  .:::.||          .:|.......||:..||
  Rat   858 QEMLQNQFNGEDTRLNINSSPDEHEPLLR--REQQAGH----------DEGVLDRLVDRRERPLE 910

  Fly   847 VFREVFSGRGSSERLRD--------PSERVKT----PGDVPPSVRKARASKTLSLYDDRMMDSSL 899
                  .||.:|.....        |::.|.:    ||...|  |:|:...:|.|....::|.|.
  Rat   911 ------GGRTNSNNNNSNPCSEQDVPTQGVTSTAADPGPAKP--RRAQRPNSLDLSATNILDGSS 967

  Fly   900 LNI 902
            :.|
  Rat   968 MQI 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	snake_toxin	57..133	CDD:264434	23/77 (30%)
		STYKc	226..517	CDD:214568	140/291 (48%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	147/300 (49%)
Bmpr2	XP_006245013.1	Activin_recp	74..145	CDD:279413	23/72 (32%)
		S_TKc	218..509	CDD:214567	142/294 (48%)
		STKc_BMPR2_AMHR2	221..518	CDD:270956	147/300 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	294	1.000	Domainoid score	I1443
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	362	1.000	Inparanoid score	I2122
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	1	1.000	-	-		FOG0006916
OrthoInspector	1	1.000	-	-		oto95783
orthoMCL	1	0.900	-	-		OOG6_110421
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5015
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.830