Protein Alignment wit and wit

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_061505462.1
• Gene: wit / 1276252
• VectorBaseID: AGAMI1_008614
• Length: 987
• Species: Anopheles gambiae
• Alignment Length: 1015
• Identity: 393/1015 - (38%)
• Similarity: 545/1015 - (53%)
• Gaps: 197/1015 - (19%)

  Fly     5 IYLLLALISLGRATPVPNRQYSCMSY---------QEDDNSFHDDDGDQDSSGELQEQQVESTPI 60
            :.:|...|:.|:|.|:.||   |:.:         |::...|.||....|...|..::.|....:
Mosquito    38 LVVLACSITGGQANPLKNR---CLQFGTTSTTNTQQQNGQEFVDDYDSYDDQPEPSDEPVFEKNV 99

  Fly    61 PSEPHRRTCPDGYTFCFTIW--NQTANGARVVKQGCWKDNTDRTSICSQSEC--TSSAPTSKTSS 121
            .:.   .||.....||:|:|  :...|..|||.||||..|.|:.| ||.:||  |:..||..
Mosquito   100 STV---ATCSRTAPFCYTLWTFDIVKNVTRVVVQGCWGSNDDQES-CSSNECISTTETPTRH--- 157

  Fly   122 LYYCCCSGGVCNAQYSVVEP--APLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTA-LT 183
             ::|||.|..||..:|.:.|  |...|...:...|||..|   .:.|..:|..:.:...|.| :|
Mosquito   158 -FFCCCRGDNCNGNFSYLPPPTAADGLSMRDENESITPFA---PYTSIWSSPTVYICFALVAIMT 218

  Fly   184 IGI--FLAVQYCRTAKEKPEPE-ESPLAPSGPGYSSNLRNVDNMNLIGMLGSGKYGTVMKGLLHD 245
            :||  ||:   ||...:|...| ...:.||||||||||.||||:.|:.|:|.||||||.||::::
Mosquito   219 LGIGGFLS---CRQLPKKGTGELLEHMEPSGPGYSSNLYNVDNLKLVSMIGQGKYGTVWKGIVNE 280

  Fly   246 QEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGRMEYQLVLSLAPLGCLQD 310
            :.|||||:..:|.||::|||:||.:||||.|:||:|||.|||.|:|.|:||.|||||||||||||
Mosquito   281 KPVAVKIFSAQHRQYFLNERDIYTVPLMESPSLLAYFGSDERRTLDDRIEYMLVLSLAPLGCLQD 345

  Fly   311 WLIANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTRNVLVQADLSCCIADFGF 375
            ||..|::.||..|.|.:||..|::|||||:|.|:..|||:.|||:|:||:||::||||||.|.||
Mosquito   346 WLTDNSVPFSTFCRMGKSIANGLAHLHTEIRKGELVKPCICHRDLNSRNILVKSDLSCCIGDLGF 410

  Fly   376 ALKVFGSKYEYKGEVAMAETKSINEVGTLRYMAPELLEGAVNLRDCETSLKQMDVYALGLVLWEV 440
            |||.||::|||:||:.:|||||||||||:||||||:|||||||||||::|||:|||.|.|||||:
Mosquito   411 ALKTFGARYEYRGEITLAETKSINEVGTVRYMAPEVLEGAVNLRDCESALKQIDVYTLALVLWEL 475

  Fly   441 ATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGWGGGAAAKVVRDTCE 505
            |.||.|||..|...|.|:||||:.|||:|:|:|||.||.|:||||.||..:|.|...::||||||
Mosquito   476 ANRCEDFYPEGTTVPEYRAPYEEYVGSNPNFEQMQVLVSRNKARPTFPAHFGTGLVTQIVRDTCE 540

  Fly   506 DCWDHDADARLTSLCAEERMQEMSTLRPRAQAQPSSPLLNTNNLVASPTAEQG----INIIATTT 566
            |||||||:||||::|.:||:||::.:.|||:..|.....:.:    .|..|:.    :....|..
Mosquito   541 DCWDHDAEARLTAMCVQERLQEVAQINPRARTMPPKGCSHDD----GPALEKAQLYQLESDGTAI 601

  Fly   567 TAAAVHHQMSSDTTGLIQPPPNQQI----PLAALEREKNHLSYPQQQLQPYQG-----------R 616
            .|...|.:.|.|.|.....||||||    |.|.. ||....||...:|....|           |
Mosquito   602 AAMMGHQRYSPDGTIAFMTPPNQQIIPQVPPAGY-REDTTGSYKYGKLSSSGGASSTTHSGAPSR 665

  Fly   617 NPCQE--------RNLAPLTMR---------TPP---------VLVERS--------------KK 641
            :...|        :.||||..|         .||         |:::::              .:
Mosquito   666 SQSDEDEQHTVGRKGLAPLIQRGEGSFEGKAMPPGKGLGGSVKVMLQKTFHKNHLAGVTAPSLVR 730

  Fly   642 HSFQTQPQ---------------ENSLSCLEHD--VSVEELIASHQHQQQKNTIVSTGGNGNSCL 689
            |::..|.:               |.|.:|...:  :|.||::.:|.:.||::
Mosquito   731 HAYDVQQKCDDTDGDRSNLVVVVETSDTCSPRNALLSEEEILMNHHNNQQQH------------- 782

  Fly   690 GQGFPKQQNTDQKLRGWHGVRALIHKKLFRKEHAEELCRQLQLGEEKSNLVTALRRPNNLDL--- 751
                .:||:..|                   :|.:      |.|        .:.||.||||
Mosquito   783 ----QQQQHVQQ-------------------QHVQ------QSG--------GVERPTNLDLGTG 810

  Fly   752 ----NPRLDKPPPDQLRSAEQRMGTPAHIVPRSLSSSL-----IKHINGTTNNNSIQSHGSELQ- 806
                |..|.:|     .|......|...:..|..:.:|     .:......:..::...|:.:.
Mosquito   811 KYESNLLLHEP-----HSVGNVTATEGAVSARGRAKALADADFTRQSFAILDEMAVDDDGATVDE 870

  Fly   807 ---------TLTRPASKRRPGHLRTNSLMATTGQGPP---TEQQMRRQHSLEVFREVFSGRGSSE 859
                     .:::.|:...|.....::...:....||   .::.::||.|||||:|||..:||.|
Mosquito   871 HHDPQKLRIVVSKSANAMHPPRGSRHTRQGSEASSPPPFLDDRSLKRQRSLEVFQEVFGPKGSIE 935

  Fly   860 RLRDPSERVKTPGDVPPSVRKARASKTLSLYDDRMMDSSL 899
            |||:||:||||||||||||||.||||||||||||||.:::
Mosquito   936 RLRNPSQRVKTPGDVPPSVRKVRASKTLSLYDDRMMTATV 975

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	38/125 (30%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	194/299 (65%)
wit	XP_061505462.1	None