DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wit and Bmpr2

DIOPT Version :9

Sequence 1:	NP_001261395.1	Gene:	wit / 44096	FlyBaseID:	FBgn0024179	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	NP_031587.1	Gene:	Bmpr2 / 12168	MGIID:	1095407	Length:	1038	Species:	Mus musculus

Alignment Length:	1038	Identity:	294/1038 - (28%)
Similarity:	443/1038 - (42%)	Gaps:	235/1038 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 YLLLALISLGRATPVPNRQYSCM---SYQEDDNSFHDDDGDQDSSGELQEQQVESTPIPSEPHRR 67
            :||.|::.:.......|::..|.   .||:|                   ..:..:.|..|....
Mouse    13 WLLWAVLLVSTTAASQNQERLCAFKDPYQQD-------------------LGIGESRISHENGTI 58

  Fly    68 TCPDGYTFCFTIWNQTANGARVVKQGCWKDNTDRTSICSQSEC--TSSAPTSKTSSLYYCCCSGG 130
            .|..|.| |:.:|.::.....:||||||....|... |...||  |::.|:.:..:..:||||..
Mouse    59 LCSKGST-CYGLWEKSKGDINLVKQGCWSHIGDPQE-CHYEECVVTTTPPSIQNGTYRFCCCSTD 121

  Fly   131 VCNAQYSVVEPAPLEL------GSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALT----IG 185
            :||..::...|.|...      ..|...|.|...|:    .|.||..::.|..|...||    .|
Mouse   122 LCNVNFTENFPPPDTTPLSPPHSFNRDETIIIALAS----VSVLAVLIVALCFGYRMLTGDRKQG 182

  Fly   186 IFLAVQYCRTAKEKPEPEESPLAPSGPGYSSNLRNVDNMNLIGMLGSGKYGTVMKGLLHDQEVAV 250
            :. ::.....|..:|.                 .::||:.|:.::|.|:||.|.||.|.::.|||
Mouse   183 LH-SMNMMEAAAAEPS-----------------LDLDNLKLLELIGRGRYGAVYKGSLDERPVAV 229

  Fly   251 KIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGRMEYQLVLSLAPLGCLQDWLIAN 315
            |::...:.|.::||:|||.:||||...:..:...|||.|.||||||.||:...|.|.|..:|..:
Mouse   230 KVFSFANRQNFINEKNIYRVPLMEHDNIARFIVGDERLTADGRMEYLLVMEYYPNGSLCKYLSLH 294

  Fly   316 TLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTRNVLVQADLSCCIADFGFALKVF 380
            |..:...|.:..|:|||:::|||||..||.:||.::|||:|:|||||:.|.:|.|:|||.::::.
Mouse   295 TSDWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGACVISDFGLSMRLT 359

  Fly   381 GSKYEYKGEVAMAETKSINEVGTLRYMAPELLEGAVNLRDCETSLKQMDVYALGLVLWEVATRCS 445
            |::....||   .:..:|:||||:||||||:|||||||||||::|||:|:|||||:.|||..||:
Mouse   360 GNRLVRPGE---EDNAAISEVGTIRYMAPEVLEGAVNLRDCESALKQVDMYALGLIYWEVFMRCT 421

  Fly   446 DFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGW-GGGAAAKVVRDTCEDCWD 509
            |.: ||::.|.|:..::.|||:||:|:.||.||.|.|.||.||..| ....|.:.:::|.|||||
Mouse   422 DLF-PGESVPDYQMAFQTEVGNHPTFEDMQVLVSREKQRPKFPEAWKENSLAVRSLKETIEDCWD 485

  Fly   510 HDADARLTSLCAEERMQEM-----------STLRPRAQAQPSSPLLNTNNLV----------ASP 553
            .||:||||:.||||||.|:           .|:.|.:.|..:...|:.|..|          :|.
Mouse   486 QDAEARLTAQCAEERMAELMMIWERNKSVSPTVNPMSTAMQNERNLSHNRRVPKIGPYPDYSSSS 550

  Fly   554 TAEQGINIIATTTTAAAVHHQMSSDTTGLIQPPPNQQIPLAALEREKNHLSYPQQQLQ------- 611
            ..|..|:...:.....:..|.|||             .||...|:.:|.::|.:||.|
Mouse   551 YIEDSIHHTDSIVKNISSEHSMSS-------------TPLTIGEKNRNSINYERQQAQARIPSPE 602

  Fly   612 ------------------------------PYQGRNPCQERNLAPLTMRTP-------------- 632
                                          ||.........|:|.....||
Mouse   603 TSVTSLSTNTTTTNTTGLTPSTGMTTISEMPYPDETHLHATNVAQSIGPTPVCLQLTEEDLETNK 667

  Fly   633 --PVLVERSKKHSFQTQPQENSLSCLEHDVSVEELIASHQHQQQKNTIVSTG-------GNGNSC 688
              |..|:::.|.|......|:||........:....:|..:...|..:..||       .||.:|
Mouse   668 LDPKEVDKNLKESSDENLMEHSLKQFSGPDPLSSTSSSLLYPLIKLAVEVTGQQDFTQAANGQAC 732

  Fly   689 L------GQGF--PKQQN-----TDQKLRGWHGVRALIHKKLFRKEHAEELCRQLQLGEEKSNLV 740
            |      .|.:  |||||     |...|...:..:.  .:..|..:|...| :|::.|..|.|.:
Mouse   733 LIPDVPPAQIYPLPKQQNLPKRPTSLPLNTKNSTKE--PRLKFGNKHKSNL-KQVETGVAKMNTI 794

  Fly   741 TALR-------------RPNNLDLNPRLDKPPPDQLRSAEQRMGTPAHIVPRSLSSSLIKHINGT 792
            .|..             |.:|::     ......|..:.....|..|:||.......|.....|.
Mouse   795 NAAEPHVVTVTMNGVAGRSHNVN-----SHAATTQYANGAVPAGQAANIVAHRSQEMLQNQFIGE 854

  Fly   793 TNNNSIQSHGSELQTLTRPASKRRPGH------------------LRTNSLMATTGQGPPTEQQM 839
            ....:|.|...|.:.|.|  .:::.||                  .||||  ......|.:||.:
Mouse   855 DTRLNINSSPDEHEPLLR--REQQAGHDEGVLDRLVDRRERPLEGGRTNS--NNNNSNPCSEQDI 915

  Fly   840 RRQHSLEVFREVFSGRGSSERLRDPSERVKTPGDVPPSVRKARASKTLSLYDDRMMDSSLLNI 902
            ..|             |.:....||.         |...|:|:...:|.|....::|.|.:.|
Mouse   916 LTQ-------------GVTSTAADPG---------PSKPRRAQRPNSLDLSATNILDGSSIQI 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	snake_toxin	57..133	CDD:264434	23/77 (30%)
		STYKc	226..517	CDD:214568	141/291 (48%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	148/300 (49%)
Bmpr2	NP_031587.1	Activin_recp	60..131	CDD:279413	23/72 (32%)
		S_TKc	204..495	CDD:214567	143/294 (49%)
		STKc_BMPR2_AMHR2	207..504	CDD:270956	148/300 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	593..626		2/32 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	746..769		7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	872..974		22/111 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	296	1.000	Domainoid score	I1466
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	363	1.000	Inparanoid score	I2173
Isobase	1	0.950	-	0	Normalized mean entropy	S5164
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006916
OrthoInspector	1	1.000	-	-		oto92217
orthoMCL	1	0.900	-	-		OOG6_110421
Panther	1	1.100	-	-	LDO	PTHR23255
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9498
SonicParanoid	1	1.000	-	-		X5015
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.800