Protein Alignment wit and Acvrl1

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_001264184.1
• Gene: Acvrl1 / 11482
• MGIID: 1338946
• Length: 517
• Species: Mus musculus
• Alignment Length: 518
• Identity: 143/518 - (27%)
• Similarity: 213/518 - (41%)
• Gaps: 77/518 - (14%)

  Fly    42 GDQDSSGELQEQQVESTPIPSEPH-RRTCPDGYTFCFTIWNQTANGARVVKQGCWKDNTDRTSIC 105
            ||.....:|.....||      || :|....| ::|..:..:.......|.:||...|
Mouse    37 GDLAKPSKLVNCTCES------PHCKRPFCQG-SWCTVVLVREQGRHPQVYRGCGSLN------- 87

  Fly   106 SQSECTSSAPTSKTSSLYYCCCSGGVCNAQYSVV---------EP-----APLELGS-------- 148
             |..|..    ..|..|.:.||....||...|::         ||     .||.||.
Mouse    88 -QELCLG----RPTEFLNHHCCYRSFCNHNVSLMLEATQTPSEEPEVDAHLPLILGPVLALPVLV 147

  Fly   149 NEGRTSI--TNRATEKQ---HQSFLASTMLGLAGGLTALTIGIFLAVQYCRTAKEKPEPEESPLA 208
            ..|...:  ..|..|||   |.....|:::..|.......:|.||... |.|.
Mouse   148 ALGALGLWRVRRRQEKQRDLHSDLGESSLILKASEQADSMLGDFLDSD-CTTG------------ 199

  Fly   209 PSGPGYSSNLRN--VDNMNLIGMLGSGKYGTVMKGLLHDQEVAVKIYPEEHHQYYVNERNIYALP 271
             ||.|....::.  ...:.|:..:|.|:||.|.:|..|.:.|||||:.....|.:..|..||...
Mouse   200 -SGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTV 263

  Fly   272 LMECPALLSYFGYDERCTMDGRMEYQLVLSLAPLGCLQDWLIANTLTFSECCGMLRSITRGISHL 336
            |:....:|.:...| ..:.:...:..|:......|.|.|:|...||.......:..|...|::||
Mouse   264 LLRHDNILGFIASD-MTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHL 327

  Fly   337 HTELRLGDQHKPCVAHRDINTRNVLVQADLSCCIADFGFALKVFGSKYEYKGEVAMAETKSINEV 401
            |.|: .|.|.||.:||||:.:|||||:::|.|||||.|.|: :.....:|      .:..:...|
Mouse   328 HVEI-FGTQGKPAIAHRDLKSRNVLVKSNLQCCIADLGLAV-MHSQSSDY------LDIGNNPRV 384

  Fly   402 GTLRYMAPELLEGAVNLRDCETSLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVG 466
            ||.||||||:|:..:. .||..|.|..|::|.||||||:|.|.    ........|:.|:...|.
Mouse   385 GTKRYMAPEVLDEHIR-TDCFESYKWTDIWAFGLVLWEIARRT----IINGIVEDYRPPFYDMVP 444

  Fly   467 SHPSFDQMQALVVRHKARPLFPTGWGGGAAAKVVRDTCEDCWDHDADARLTSLCAEERMQEMS 529
            :.|||:.|:.:|...:..|..|...........:.....:||..:..||||:|..::.:|::|
Mouse   445 NDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKLS 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	22/96 (23%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	96/299 (32%)
Acvrl1	NP_001264184.1	TFP_LU_ECD_ALK1	45..112	CDD:467064	20/85 (24%)
		TGF_beta_GS	188..214	CDD:462503	8/39 (21%)
		STKc_ACVR1_ALK1	210..507	CDD:271044	97/310 (31%)