Protein Alignment wit and Acvr2b

DIOPT Version :9

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_036010460.1
• Gene: Acvr2b / 11481
• MGIID: 87912
• Length: 557
• Species: Mus musculus
• Alignment Length: 510
• Identity: 165/510 - (32%)
• Similarity: 264/510 - (51%)
• Gaps: 74/510 - (14%)

  Fly    76 CFTIWNQTANGARVVKQGCWKDNTDRTSIC-SQSECTSSAPTSKTSSLYYCCCSGGVCNAQYS-V 138
            |:..|..::....:||:|||.|:.:    | .:.||.:   |.:...:|:|||.|..||.::: :
Mouse    80 CYASWRNSSGTIELVKKGCWLDDFN----CYDRQECVA---TEENPQVYFCCCEGNFCNERFTHL 137

  Fly   139 VEPAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALTIGIFL--------------- 188
            .||...|:......|:.|       ..:.||.::|.: |||:.:.:..|.
Mouse   138 PEPGGPEVTYEPPPTAPT-------LLTVLAYSLLPI-GGLSLIVLLAFWMYRHRKPPYGHVDIH 194

  Fly   189 AVQYCR---------TAKEKPEPEESPLAPSGPGYSSNLRNVDNMNLIGMLGSGKYGTVMKGLLH 244
            .|:.|:         ....||.|.:.|    ||...|.|..:..:.|:.:...|::|.|.|..|.
Mouse   195 EVRQCQRWAGRRDGCADSFKPLPFQDP----GPPPPSPLVGLKPLQLLEIKARGRFGCVWKAQLM 255

  Fly   245 DQEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGRMEYQLVLSLAPLGCLQ 309
            :..|||||:|.:..|.:.:||.|::.|.|:...||.:...::|.: :..:|..|:.:....|.|.
Mouse   256 NDFVAVKIFPLQDKQSWQSEREIFSTPGMKHENLLQFIAAEKRGS-NLEVELWLITAFHDKGSLT 319

  Fly   310 DWLIANTLTFSECCGMLRSITRGISHLHTELR--LGDQHKPCVAHRDINTRNVLVQADLSCCIAD 372
            |:|..|.:|::|.|.:..:::||:|:||.::.  .|:.|||.:||||..::|||:::||:..:||
Mouse   320 DYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLAD 384

  Fly   373 FGFALKVFGSKYEYKGEVAMAETKSINEVGTLRYMAPELLEGAVNL-RDCETSLKQMDVYALGLV 436
            ||.|::.         |.......:..:|||.||||||:||||:|. ||   :..::|:||:|||
Mouse   385 FGLAVRF---------EPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRD---AFLRIDMYAMGLV 437

  Fly   437 LWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGW--GGGAAAKV 499
            |||:.:||.....|   ...|..|:|:|:|.|||.:::|.:||..|.||.....|  ..|.|...
Mouse   438 LWELVSRCKAADGP---VDEYMLPFEEEIGQHPSLEELQEVVVHKKMRPTIKDHWLKHPGLAQLC 499

  Fly   500 VRDTCEDCWDHDADARLTSLCAEERMQEMSTLRPRAQAQPSSPLLNTNNLVASPT 554
            |  |.|:||||||:|||::.|.|||   :|.:|.......|..|:   :||.|.|
Mouse   500 V--TIEECWDHDAEARLSAGCVEER---VSLIRRSVNGTTSDCLV---SLVTSVT 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	snake_toxin	57..133	CDD:264434	17/57 (30%)
		STYKc	226..517	CDD:214568	111/295 (38%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	115/304 (38%)
Acvr2b	XP_036010460.1	Activin_recp	62..131	CDD:395845	17/57 (30%)
		STKc_ACVR2b	239..529	CDD:271042	117/310 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820