Protein Alignment wit and Acvr2a

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_006497686.1
• Gene: Acvr2a / 11480
• MGIID: 102806
• Length: 521
• Species: Mus musculus
• Alignment Length: 501
• Identity: 165/501 - (32%)
• Similarity: 262/501 - (52%)
• Gaps: 75/501 - (14%)

  Fly    76 CFTIWNQTANGARVVKQGCWKDNT---DRTSICSQSECTSSAPTSKTSSLYYCCCSGGVCNAQYS 137
            ||..|...:....:||||||.|:.   |||....:.:         :..:|:|||.|.:||.::|
Mouse    60 CFATWKNISGSIEIVKQGCWLDDINCYDRTDCIEKKD---------SPEVYFCCCEGNMCNEKFS 115

  Fly   138 ------VVEPAPLELGSNEGRTSITNRATEK-QHQSFLASTMLGLAGGLTALTIGIFL-AVQYCR 194
                  |.:|.             :|..|.| .:.:.|..:::.|     .|..||.: |....|
Mouse   116 YFPEMEVTQPT-------------SNPVTPKPPYYNILLYSLVPL-----MLIAGIVICAFWVYR 162

  Fly   195 TAKEKPEPEESP--------LAPSGPGYSSNLRNVDNMNLIGMLGSGKYGTVMKGLLHDQEVAVK 251
            ..|....|...|        :...||...|.|..:..:.|:.:...|::|.|.|..|.::.||||
Mouse   163 HHKMAYPPVLVPTQHAFHIMIEDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVK 227

  Fly   252 IYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCT-MDGRMEYQLVLSLAPLGCLQDWLIAN 315
            |:|.:..|.:.||..:|:||.|:...:|.:.|.::|.| :|  ::..|:.:....|.|.|:|.||
Mouse   228 IFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVD--VDLWLITAFHEKGSLSDFLKAN 290

  Fly   316 TLTFSECCGMLRSITRGISHLHTEL-RLGDQHKPCVAHRDINTRNVLVQADLSCCIADFGFALKV 379
            .::::|.|.:..::.||:::||.:: .|.|.|||.::||||.::|||::.:|:.||||||.|||.
Mouse   291 VVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKF 355

  Fly   380 FGSKYEYKGEVAMAETKSINEVGTLRYMAPELLEGAVNL-RDCETSLKQMDVYALGLVLWEVATR 443
                     |...:...:..:|||.||||||:||||:|. ||   :..::|:||:||||||:|:|
Mouse   356 ---------EAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRD---AFLRIDMYAMGLVLWELASR 408

  Fly   444 CSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGWGGGAAAKVVRDTCEDCW 508
            |:....|   ...|..|:|:|:|.|||.:.||.:||..|.||:....|...|...::.:|.|:||
Mouse   409 CTAADGP---VDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECW 470

  Fly   509 DHDADARLTSLCAEERMQEMSTLRPRAQAQPSSPLLNTNNLVASPT 554
            ||||:|||::.|..||:.:|..|         :.::.|.::|...|
Mouse   471 DHDAEARLSAGCVGERITQMQRL---------TNIITTEDIVTVVT 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	21/70 (30%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	119/302 (39%)
Acvr2a	XP_006497686.1	TFP_LU_ECD_ACVR2A	25..119	CDD:467151	21/67 (31%)
		STKc_ACVR2a	204..493	CDD:271043	120/305 (39%)