Protein Alignment wit and Amhr2

DIOPT Version :9

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: NP_001343504.1
• Gene: Amhr2 / 110542
• MGIID: 105062
• Length: 568
• Species: Mus musculus
• Alignment Length: 591
• Identity: 180/591 - (30%)
• Similarity: 269/591 - (45%)
• Gaps: 106/591 - (17%)

  Fly     3 WAIYLLLALISLGRATPVPNRQYSCMSYQEDDNSFHDDDGDQDSSGELQEQQVESTPIPSEPHRR 67
            |.:....|.:|       |||: :|:        |.:..|.:.|:..|.| .|::.|.|
Mouse     8 WTLLPAAAQVS-------PNRR-TCV--------FFEAPGVRGSTKTLGE-MVDAGPGP------ 49

  Fly    68 TCPDG----YTF-CFTIWNQTANGARVVKQGCWKDNTDRTSICSQSEC--TSSAPTSKTSSLYYC 125
              |.|    |:. ||.|||.|...|:|..||| :|:.:..  |....|  ...|..:.:|:|:.|
Mouse    50 --PKGIRCLYSHCCFGIWNLTHGRAQVEMQGC-RDSDEPG--CESLHCDPVPRAHPNPSSTLFTC 109

  Fly   126 CCSGGVCNAQYSVVEPAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALTIGIFLAV 190
            .|....|||.||.:.|:     .|:|...............::|..:||:.  |..|...|.||:
Mouse   110 SCGTDFCNANYSHLPPS-----GNQGAPGPQEPQATPGGPVWMALLLLGMF--LVLLLSSIILAL 167

  Fly   191 ---QYCRT-AKEKPEPEESPLAPSGPGYSSNLRNVDNMNLIGMLGSGKYGTVMKGLLHDQEVAVK 251
               :.||. ....|||      .||...|..|..:..:....::..|.:..|..|.|..:.||:|
Mouse   168 LQRKACRVQGGSDPEP------GSGGDCSEELPELAELRFSQVIQEGGHAVVWAGRLQGEMVAIK 226

  Fly   252 IYPEEHHQYYVNERNIYAL--------------------PLMECPALLSYFGYDERCTMDGRMEY 296
            .:|......:..||.:|.|                    ||...|.
Mouse   227 AFPPRAVAQFRAERAVYQLLGLQHDHIVRFITAGQGGPGPLPSGPL------------------- 272

  Fly   297 QLVLSLAPLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTRNVL 361
             |||.|.|.|.|..:|...|..:.....|..|:..|::.||.|.....|:||.:||||::::|||
Mouse   273 -LVLELYPKGSLCHYLTQYTSDWGSSLRMALSLAEGLAFLHEERWQDGQYKPGIAHRDLSSQNVL 336

  Fly   362 VQADLSCCIADFGFALKVFGSKYEYKGEVAMAETK-----SINEVGTLRYMAPELLEGAVNLRDC 421
            ::.|.||.|.|.|.||.:.|    .....|:|.|:     :|.|.||.||||||||:..::|:|.
Mouse   337 IREDRSCAIGDLGLALVLPG----LAQPPALAPTQPRGPAAILEAGTQRYMAPELLDKTLDLQDW 397

  Fly   422 ETSLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPL 486
            .|:|::.|||:|.|:|||:.:||||. .|....||::..||.|:||:||..::.||.|..:.||.
Mouse   398 GTALQRADVYSLALLLWEILSRCSDL-RPDHRPPPFQLAYEAELGSNPSACELWALAVEERKRPN 461

  Fly   487 FPTGWGGGAA-AKVVRDTCEDCWDHDADARLTSLCAEERMQEMSTLRPR-AQAQPSSPLLNTNNL 549
            .|:.|...|. .:.:|:..|||||.|.:||||:.|.::|:..::  .|. |.:.|.||.....|.
Mouse   462 IPSTWSCSATDPRGLRELLEDCWDADPEARLTAECVQQRLAALA--YPHGASSFPESPQGCPENC 524

  Fly   550 VASPTA 555
            :::|.:
Mouse   525 LSAPAS 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	snake_toxin	57..133	CDD:264434	24/82 (29%)
		STYKc	226..517	CDD:214568	107/316 (34%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	111/325 (34%)
Amhr2	NP_001343504.1	Activin_recp	<61..119	CDD:307282	21/60 (35%)
		PKc_like	203..504	CDD:328722	111/325 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834708
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D191771at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750