Protein Alignment wit and acvr1c

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_002933316.2
• Gene: acvr1c / 100487548
• XenbaseID: XB-GENE-487108
• Length: 537
• Species: Xenopus tropicalis
• Alignment Length: 501
• Identity: 138/501 - (27%)
• Similarity: 214/501 - (42%)
• Gaps: 92/501 - (18%)

  Fly    76 CFTIWNQTANGARVVKQGCW--------KDNTDRTSIC-----SQSECTSSAPTSKTSSLYYCCC 127
            |..:..:..|.....:..||        |:...::.|.     :|..|.||...::|.     ||
 Frog    72 CVCLLCENTNYTCQTEGACWTSVMLTHGKEEVLKSCISLPEFKAQVFCHSSNNITRTE-----CC 131

  Fly   128 SGGVCN---AQYSVVEPAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALTIGIFLA 189
            ....||   .:...|.|....:|..|....:|           ::..:|.:...:||..    ..
 Frog   132 LSDFCNNITLRLPAVTPGVSHMGHVELTVIVT-----------VSICLLSVVIMVTAYV----CQ 181

  Fly   190 VQYCRTAKEKPEPEESPL-------------------APSGPGYSSNL---RNVDNMNLI-GMLG 231
            .:||...|.:.:..|.||                   ..||.|....|   |.:....:| .::|
 Frog   182 ERYCAKNKARRQCVEEPLTECPLDIAGKSLKDLIYDMTTSGSGSGLPLLVQRTIARTVVIQELVG 246

  Fly   232 SGKYGTVMKGLLHDQEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGRMEY 296
            .|::|.|.:|....::|||||:.....:.:..|..||...::....:|.:...|.:   |.....
 Frog   247 KGRFGEVWRGKWCGEDVAVKIFSSRDERSWFREAEIYQTVMLRHENILGFIAADNK---DNGTWT 308

  Fly   297 Q--LVLSLAPLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRDINTRN 359
            |  |:......|.|.|:|..||:|......:..|:..|::|||.|: :|.|.||.:||||:.::|
 Frog   309 QLWLISEFHEQGSLFDYLNCNTVTIGGMMKLALSVVSGLAHLHMEI-VGTQGKPAIAHRDLKSKN 372

  Fly   360 VLVQADLSCCIADFGFALKVFGSKYEYKGEVAMAETKSINE---VGTLRYMAPELLEGAVNLRDC 421
            :||:.:.:|||||.|.|:|          ..::..|..|.:   |||.||||||||:.::|....
 Frog   373 ILVKKNETCCIADLGLAVK----------HDSITNTIDIPQNPRVGTKRYMAPELLDDSINTYHF 427

  Fly   422 ETSLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPL 486
            : |.|..|:|:||||.||:|.|||    .|.....|:.||...|.|.||.:.::.:|...|.||.
 Frog   428 D-SFKCSDIYSLGLVYWEIARRCS----VGGVVDEYQLPYYDMVPSDPSLEDVRKVVCEQKLRPS 487

  Fly   487 FPTGWGGGAAAKVVRDTCEDCWDHDADARLTS---------LCAEE 523
            .|..|....|.:::.....:||..:..||||:         ||.||
 Frog   488 IPNQWQSFEALRIMGRIMRECWYANGKARLTALRIKKTISQLCVEE 533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	15/77 (19%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	103/310 (33%)
acvr1c	XP_002933316.2	TFP_LU_ECD_ALK7	68..143	CDD:467070	15/75 (20%)
		TGF_beta_GS	210..237	CDD:462503	5/26 (19%)
		STKc_TGFbR1_ACVR1b_ACVR1c	243..530	CDD:271045	99/305 (32%)