Protein Alignment wit and tgfbr2a

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_073787446.1
• Gene: tgfbr2a / 100334928
• ZFINID: ZDB-GENE-120404-1
• Length: 659
• Species: Danio rerio
• Alignment Length: 564
• Identity: 157/564 - (27%)
• Similarity: 247/564 - (43%)
• Gaps: 125/564 - (22%)

  Fly    42 GDQDSSGEL-----QEQQVESTPIPSEPH-RRTCPDGYTFCFTIWNQTANGARVVKQGC------ 94
            |||.:...|     :|:::..|...|... ::.|    .|| .:.:...|.:.|.:..|
Zfish   120 GDQCNQNLLLRKLTEEEKLSKTNSSSGFRLKQNC----KFC-DVESSVCNASGVCESACGINSIC 179

  Fly    95 ----------WKDNTDRTSI---C--------------SQSECTSSAPTSKTSSLYYCCCSGGVC 132
                      |:.|...:||   |              |||.........:  .||.|.|:...|
Zfish   180 ETPDEVCASAWRSNGGNSSIETVCHNPALLFHGHNLTDSQSRVCQMRRVEE--DLYICSCNDEEC 242

  Fly   133 N---------AQYSVVE-PAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALTIGI- 186
            |         .||..|: ..|.|                        |:...||..|.::.:.|
Zfish   243 NDRLFFNHDLKQYPGVQFDPPSE------------------------SSWFSLAPVLISVFVLIP 283

  Fly   187 --FLAVQYC-RTAKEKPE-PEESPL---------APSGPGYSSNLRNVDNMN---------LIGM 229
              .|:|.|| ..::.|.: |.:..|         .|.....||:: |.:::|         |..:
Zfish   284 IVLLSVFYCYHISQHKLKLPNKKSLDSERCNIFMNPEEHSDSSSI-NANSLNHNTELLPIQLDRV 347

  Fly   230 LGSGKYGTVMKGLLHD-----QEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCT 289
            :|.|::..|.|..|..     |.|||||:|.|....:.:|..|::...:....:|.:...:||
Zfish   348 VGKGRFADVYKAKLKQSADSFQTVAVKIFPYEEFSSWKSEWQIFSDVELRHENVLQFLTAEER-- 410

  Fly   290 MDGRMEYQLVLSLAPLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRD 354
             ....:|.|:.:....|.||:.|....:.:.|.|.:..|:.||::|||::.....:.|..:||||
Zfish   411 -TAERQYWLITAYHERGNLQELLALQVIGWEEMCRLGVSLARGVAHLHSDRTPCGRAKVSIAHRD 474

  Fly   355 INTRNVLVQADLSCCIADFGFALKVFGSKYEYKGEVAMAETKSINEVGTLRYMAPELLEGAVNLR 419
            :.:.||||::|.|||:.|||.:|::...       ::..|..:..:|||.||||||:||..::|.
Zfish   475 LKSSNVLVKSDWSCCVCDFGLSLRLDSC-------LSPEELANSGQVGTARYMAPEVLESRMDLE 532

  Fly   420 DCETSLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKAR 484
            :.| |.||.|||::.|||||:.:|||   |.|... .|:.|:.:..| ||..:.|:..|:|.:.|
Zfish   533 NTE-SFKQADVYSMALVLWEIMSRCS---ATGDVR-DYEPPFGKLKG-HPCVESMKDDVIRDRLR 591

  Fly   485 PLFPTGWGGGAAAKVVRDTCEDCWDHDADARLTSLCAEERMQEM 528
            |..||.|...|....:..|.|:|||||.:||||:.|..||..::
Zfish   592 PEIPTSWSKHAGVHHLSSTIEECWDHDPEARLTAQCVVERFDDI 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	29/143 (20%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	107/304 (35%)
tgfbr2a	XP_073787446.1	None