DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wit and tgfbr2a

DIOPT Version :9

Sequence 1:	NP_001261395.1	Gene:	wit / 44096	FlyBaseID:	FBgn0024179	Length:	913	Species:	Drosophila melanogaster
Sequence 2:	XP_009292206.2	Gene:	tgfbr2a / 100334928	ZFINID:	ZDB-GENE-120404-1	Length:	659	Species:	Danio rerio

Alignment Length:	564	Identity:	157/564 - (27%)
Similarity:	247/564 - (43%)	Gaps:	125/564 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 GDQDSSGEL-----QEQQVESTPIPSEPH-RRTCPDGYTFCFTIWNQTANGARVVKQGC------ 94
            |||.:...|     :|:::..|...|... ::.|    .|| .:.:...|.:.|.:..|
Zfish   120 GDQCNQNLLLRKLTEEEKLSKTNSSSGFRLKQNC----KFC-DVESSVCNASGVCESACGINSIC 179

  Fly    95 ----------WKDNTDRTSI---C--------------SQSECTSSAPTSKTSSLYYCCCSGGVC 132
                      |:.|...:||   |              |||.........:  .||.|.|:...|
Zfish   180 ETPDEVCASAWRSNGGNSSIETVCHNPALLFHGHNLTDSQSRVCQMRRVEE--DLYICSCNDEEC 242

  Fly   133 N---------AQYSVVE-PAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLAGGLTALTIGI- 186
            |         .||..|: ..|.|                        |:...||..|.::.:.|
Zfish   243 NDRLFFNHDLKQYPGVQFDPPSE------------------------SSWFSLAPVLISVFVLIP 283

  Fly   187 --FLAVQYC-RTAKEKPE-PEESPL---------APSGPGYSSNLRNVDNMN---------LIGM 229
              .|:|.|| ..::.|.: |.:..|         .|.....||:: |.:::|         |..:
Zfish   284 IVLLSVFYCYHISQHKLKLPNKKSLDSERCNIFMNPEEHSDSSSI-NANSLNHNTELLPIQLDRV 347

  Fly   230 LGSGKYGTVMKGLLHD-----QEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCT 289
            :|.|::..|.|..|..     |.|||||:|.|....:.:|..|::...:....:|.:...:||
Zfish   348 VGKGRFADVYKAKLKQSADSFQTVAVKIFPYEEFSSWKSEWQIFSDVELRHENVLQFLTAEER-- 410

  Fly   290 MDGRMEYQLVLSLAPLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRLGDQHKPCVAHRD 354
             ....:|.|:.:....|.||:.|....:.:.|.|.:..|:.||::|||::.....:.|..:||||
Zfish   411 -TAERQYWLITAYHERGNLQELLALQVIGWEEMCRLGVSLARGVAHLHSDRTPCGRAKVSIAHRD 474

  Fly   355 INTRNVLVQADLSCCIADFGFALKVFGSKYEYKGEVAMAETKSINEVGTLRYMAPELLEGAVNLR 419
            :.:.||||::|.|||:.|||.:|::...       ::..|..:..:|||.||||||:||..::|.
Zfish   475 LKSSNVLVKSDWSCCVCDFGLSLRLDSC-------LSPEELANSGQVGTARYMAPEVLESRMDLE 532

  Fly   420 DCETSLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGSHPSFDQMQALVVRHKAR 484
            :.| |.||.|||::.|||||:.:|||   |.|... .|:.|:.:..| ||..:.|:..|:|.:.|
Zfish   533 NTE-SFKQADVYSMALVLWEIMSRCS---ATGDVR-DYEPPFGKLKG-HPCVESMKDDVIRDRLR 591

  Fly   485 PLFPTGWGGGAAAKVVRDTCEDCWDHDADARLTSLCAEERMQEM 528
            |..||.|...|....:..|.|:|||||.:||||:.|..||..::
Zfish   592 PEIPTSWSKHAGVHHLSSTIEECWDHDPEARLTAQCVVERFDDI 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	snake_toxin	57..133	CDD:264434	20/109 (18%)
		STYKc	226..517	CDD:214568	103/295 (35%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	107/304 (35%)
tgfbr2a	XP_009292206.2	ecTbetaR2	30..131	CDD:312466	4/10 (40%)
		ecTbetaR2	153..249	CDD:312466	20/102 (20%)
		STKc_TGFbR2_like	347..636	CDD:270957	107/305 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG3653
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810