Protein Alignment wit and acvr2bb

DIOPT Version :10

• Sequence 1: NP_001261395.1
• Gene: wit / 44096
• FlyBaseID: FBgn0024179
• Length: 913
• Species: Drosophila melanogaster
• Sequence 2: XP_002667626.1
• Gene: acvr2bb / 100331938
• ZFINID: ZDB-GENE-170621-5
• Length: 511
• Species: Danio rerio
• Alignment Length: 585
• Identity: 170/585 - (29%)
• Similarity: 276/585 - (47%)
• Gaps: 130/585 - (22%)

  Fly     3 WAIYLLLALISLGRATPVPNRQYSCMSYQE-------DDNSFHDDDGDQDSSGELQEQQVESTPI 60
            |..:.|:....:..| .|..|:  |:.|.:       :.:.|...:|::|..
Zfish     5 WLAFALVWCTGVSHA-EVATRE--CVYYNDNWRTEKTNQSGFERCEGEKDKR------------- 53

  Fly    61 PSEPHRRTCPDGYTFCFTIWNQTANGARVVKQGCWKDNTDRTSIC-SQSECTSSAPTSKTSSLYY 124
                         ..|:..|..:....|:||:|||.|:.:    | .:.||.:   |.::..:::
Zfish    54 -------------LHCYASWLNSTGTIRLVKKGCWLDDFN----CYDRQECVA---TEESPQVFF 98

  Fly   125 CCCSGGVCNAQYSVV-------------EPAPLELGSNEGRTSITNRATEKQHQSFLASTMLGLA 176
            |||.|..||.:::.:             :|.|...|                   .|..::|.||
Zfish    99 CCCEGNYCNEKFTHLPEAIAPAVKIQPPQPGPSLFG-------------------ILVYSLLPLA 144

  Fly   177 GGLTALTIGIFLAVQYCRTAKEKPEP-------EESPLAPSGPGYSSNLRNVDNMNLIGMLGSGK 234
                .|::.:.||   |.|..::..|       :::.|.|..|     |..:..:.|:.:...|:
Zfish   145 ----ILSLALVLA---CWTYHQRKPPYRHVDIGQDAGLPPPSP-----LVGLKPLQLLELKARGR 197

  Fly   235 YGTVMKGLLHDQEVAVKIYPEEHHQYYVNERNIYALPLMECPALLSYFGYDERCTMDGRMEYQLV 299
            :|.|.|..|..:.|||||:|.:..|.:.|||:||.....:...:|.|...::|.| :.:||..||
Zfish   198 FGCVWKAQLLSEYVAVKIFPIQDKQSWQNERDIYLTEGFKHENILHYISAEKRGT-NLQMELWLV 261

  Fly   300 LSLAPLGCLQDWLIANTLTFSECCGMLRSITRGISHLHTELRL-GDQHKPCVAHRDINTRNVLVQ 363
            ......|.|.|:|..|.:::.:.|.:..|::||:::||.:|.. .:..||.:||||..::|||::
Zfish   262 TEFHERGSLTDYLKGNVVSWPQLCHISASMSRGLAYLHEDLPYRAEGPKPAIAHRDFKSKNVLLK 326

  Fly   364 ADLSCCIADFGFALKVFGSKYEYKGEVAMAETKSINEVGTLRYMAPELLEGAVNL-RDCETSLKQ 427
            .||:..|||||.|::.         |.......:..:|||.||||||:||||:|. ||   |..:
Zfish   327 MDLTAVIADFGLAVRF---------EPGKPPGDTHGQVGTRRYMAPEVLEGAINFQRD---SFLR 379

  Fly   428 MDVYALGLVLWEVATRCSDFYAP-GQATPPYKAPYEQEVGSHPSFDQMQALVVRHKARPLFPTGW 491
            :|:|||||||||:.:||:....| |:    |:.|:|:|||.|||.:.:|..||..|.||:|...|
Zfish   380 IDMYALGLVLWELVSRCTASDGPVGE----YQLPFEEEVGQHPSLEDLQDAVVHKKMRPVFKDCW 440

  Fly   492 GGGAAAKVVRDTCEDCWDHDADARLTSLCAEERMQEMSTLRPRAQAQPSSPLLNTNNLVASPTAE 556
            ........:.:|.|:||||||:|||::.|.|||:..:|               .:||.:.:.|:|
Zfish   441 VKHQGLSQLCETIEECWDHDAEARLSAGCVEERISTIS---------------KSNNTLNTSTSE 490

  Fly   557  556
            Zfish   491  490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wit	NP_001261395.1	TFP_LU_ECD_Wit	25..138	CDD:467138	24/120 (20%)
		STKc_BMPR2_AMHR2	228..528	CDD:270956	118/302 (39%)
acvr2bb	XP_002667626.1	TFP_LU_ECD_ACVR2B	23..113	CDD:467152	25/124 (20%)
		Protein Kinases, catalytic domain	191..480	CDD:473864	119/320 (37%)