DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fus and ESRP2

DIOPT Version :9

Sequence 1:	NP_524691.1	Gene:	fus / 44095	FlyBaseID:	FBgn0023441	Length:	967	Species:	Drosophila melanogaster
Sequence 2:	NP_001352193.1	Gene:	ESRP2 / 80004	HGNCID:	26152	Length:	727	Species:	Homo sapiens

Alignment Length:	891	Identity:	322/891 - (36%)
Similarity:	421/891 - (47%)	Gaps:	214/891 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PEHVVSLYIATCGQNGSGLGSDEKEIILLVFVLLEVSTGQIVGTKQILVRPDGYFIKDRTISSSS 68
            |..:|.|:.||.|..|..|||||.::||||:.::|..:.|:....:.|||.:...:..:
Human    27 PGSLVVLFGATAGALGRDLGSDETDLILLVWQVVEPRSRQVGTLHKSLVRAEAAALSTQ------ 85

  Fly    69 DNSSVTNNTASSPPLAIGDANNGSGSTSGNGNSLENGSELILPIAEAQAAGKPLSEAIEEFDAYL 133
                               ....||.:                 |::.|..:||.:.:::|...:
Human    86 -------------------CREASGLS-----------------ADSLARAEPLDKVLQQFSQLV 114

  Fly   134 RS--LSLHDTEIKLVTDGQLPLRQCLHREASAKDVELPAYYNRFSDLRKEF-LRYKSGDLARALV 195
            ..  ..|......|.||||..|||.||.|||.|::.||..:..|.|||:|| :::.|...||.|.
Human   115 NGDVALLGGGPYMLCTDGQQLLRQVLHPEASRKNLVLPDMFFSFYDLRREFHMQHPSTCPARDLT 179

  Fly   196 PVKDVKKMLQAPTLPMPQSIAEMLGELNISSVEDNDFYIRESRDMVTVIQTLLQ--AGHKFAANE 258
            ..                ::|:.|| |...:.|| ||.:.|.:.||.||..||:  :...|:..|
Human   180 VA----------------TMAQGLG-LETDATED-DFGVWEVKTMVAVILHLLKEPSSQLFSKPE 226

  Fly   259 LVNLVLEPGICSID----------DEVDGNCIVRARGLPWQSSDQDIAKFFRGLNVAKGGVALCL 313
            ::....|.|.||..          |.||...:||||||||||||||:|:||:|||||:|||||||
Human   227 VIKQKYETGPCSDSTVPCPYSSKADVVDSETVVRARGLPWQSSDQDVARFFKGLNVARGGVALCL 291

  Fly   314 SPLGRRNGEALIRFVCQEHRDMALKRHKHHIGTRYIEVYRASGEDFLAIAGGASNEAQAFLSKGA 378
            :..||||||||||||..|.||:||:|||||:|.||||||:|:||:|:.||||.|.|...|||:..
Human   292 NAQGRRNGEALIRFVDSEQRDLALQRHKHHMGVRYIEVYKATGEEFVKIAGGTSLEVARFLSRED 356

  Fly   379 QVIIRMRGLPYDATAKQVLDFFTTGDTPPCHVLDGNEGVLFVKKPDGRATGDAFVLFANETDAPK 443
            |||:|:||||:.|....||.|.    .|.|.|..|.||:|||:.||||.|||||.|||.|..|..
Human   357 QVILRLRGLPFSAGPTDVLGFL----GPECPVTGGTEGLLFVRHPDGRPTGDAFALFACEELAQA 417

  Fly   444 ALGRHRESIGQRYIELFRSTTAEVQQVLNRSMDPKNYESGGGHSQPPLIAQLPTMQLPLLPQVGA 508
            ||.||:..:|:|||||||||.|||||||||      |.||      ||   |||:..|||
Human   418 ALRRHKGMLGKRYIELFRSTAAEVQQVLNR------YASG------PL---LPTLTAPLL----- 462

  Fly   509 HSLSHSLGASPANLCPPVPPPALPLPTQHLITSGTTKNCIRLRGLPYEAMVEHILHFLDDFAKHI 573
                            |:|.|..|         ||.::|:|||||||.|.:|.||.||.:.|..|
Human   463 ----------------PIPFPLAP---------GTGRDCVRLRGLPYTATIEDILSFLGEAAADI 502

  Fly   574 IYQGVHMVINAQGQPSGEAFIQMDLEESARLCAQRRHNHYMMFGKKYRYIEVFQCSGDDMNMVLN 638
            ...|||||:|.||:|||:|||||...|.|...|||.|...|    |.||:||..||.::|:.||.
Human   503 RPHGVHMVLNQQGRPSGDAFIQMTSAERALAAAQRCHKKVM----KERYVEVVPCSTEEMSRVLM 563

  Fly   639 GGLASPVAQPPPPHLGHAHKQQSLLAATTGMFSSAGQSPTTVAAGTAQSPLGGTHTHTHPHSHAH 703
            ||........|||     .|...|...|...|.:   :||.:...||
Human   564 GGTLGRSGMSPPP-----CKLPCLSPPTYTTFQA---TPTLIPTETA------------------ 602

  Fly   704 AHATGHAHAAAAAAHHGLSASSAMLPGLSAAASASGLASFMSAGQQSAAAAAHSAASLQNAAVAL 768
                            .|..|||:||.....|:.:.:|.:.....|   ...:..|...:..|:.
Human   603 ----------------ALYPSSALLPAARVPAAPTPVAYYPGPATQ---LYLNYTAYYPSPPVSP 648

  Fly   769 APQGYALNPFSLPPPGSAAAAAASTPALLAQQQAQFIAQQSLLVRQQAAAAALAAEQQQQQQQQQ 833
            ...||...|       :||.|:|.|..|         :|...|||.|...
Human   649 TTVGYLTTP-------TAALASAPTSVL---------SQSGALVRMQGVP--------------- 682

  Fly   834 QLYASAMLQQHPLYLQQQQQQQQLYA---SAMLQQGQPQFVLMQRP 876
              |.:.|.....::     |..||.|   ::::..|.|...::|.|
Human   683 --YTAGMKDLLSVF-----QAYQLPADDYTSLMPVGDPPRTVLQAP 721

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fus	NP_524691.1	DnaQ_like_exo	13..194	CDD:299142	51/183 (28%)
		RRM1_Fusilli	280..359	CDD:241182	61/78 (78%)
		RRM2_Fusilli	363..462	CDD:241185	54/98 (55%)
		RRM3_Fusilli	545..629	CDD:241187	44/83 (53%)
ESRP2	NP_001352193.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		DnaQ_like_exo	<86..214	CDD:324557	47/162 (29%)
		RRM1_ESRPs_Fusilli	258..332	CDD:240951	58/73 (79%)
		RRM_SF	342..448	CDD:327398	65/115 (57%)
		RRM3_ESRP1_ESRP2	474..554	CDD:241186	44/83 (53%)
		Atrophin-1	<565..676	CDD:331285	33/171 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155210
Domainoid	1	1.000	446	1.000	Domainoid score	I526
eggNOG	1	0.900	-	-		E1_KOG1365
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32617
Inparanoid	1	1.050	446	1.000	Inparanoid score	I1639
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003476
OrthoInspector	1	1.000	-	-		otm42228
orthoMCL	1	0.900	-	-		OOG6_104528
Panther	1	1.100	-	-	LDO	PTHR13976
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2364
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.750