DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fus and Rbm12b2

DIOPT Version :9

Sequence 1:	NP_524691.1	Gene:	fus / 44095	FlyBaseID:	FBgn0023441	Length:	967	Species:	Drosophila melanogaster
Sequence 2:	NP_001343491.1	Gene:	Rbm12b2 / 77604	MGIID:	1924854	Length:	834	Species:	Mus musculus

Alignment Length:	407	Identity:	91/407 - (22%)
Similarity:	152/407 - (37%)	Gaps:	104/407 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   284 RGLPWQSSDQDIAKFFRGLNVAKGGVALCLSPLGRRNGEALIRFVCQEHRDMALKRHKHHIGTRY 348
            ||||:..::.|:..||.||.|  .||.|.....||.||:|:::|.........||.|:..:|:|:
Mouse   159 RGLPYLVNEDDVRVFFSGLCV--DGVILLKHHDGRNNGDAIVKFASCVDASGGLKCHRSFMGSRF 221

  Fly   349 IEVYRASGEDFLAIAGGA------------------------------SNEAQAFLSKGAQVIIR 383
            |||.:.|.:.::...|.|                              |...:|.........:.
Mouse   222 IEVMQGSEQQWIEFGGTATEGGDTPRMRSEEHSPSRRINGRHFRKRSHSKSPRARSRSPLGFYVH 286

  Fly   384 MRGLPYDATAKQVLDFFTTGDTPPCHVLDGNEGVLFVKKPDGRATGDAFVLFANETDAPKALGRH 448
            ::.|..:...:.:.:.|...|..       |:.:.||.| |.|.|..|||:|.|:.|...|||.|
Mouse   287 LKNLSLNTNKRDLRNLFRDTDLT-------NDQIKFVYK-DERRTRYAFVMFKNQKDYNTALGLH 343

  Fly   449 RESIGQRYIELFRSTTAEVQQVLNRSMDPKNYESGGGHSQPPLIAQLPTMQLPLLPQVGAHSLSH 513
            :..:..|.:.:...:..|:.::: ...:.|..||        |..:.|          |..|..:
Mouse   344 KTVLQYRPVLIDPVSRKEMVRII-ECYEKKRPES--------LEKERP----------GRVSQKY 389

  Fly   514 SLGASPANLCPPVPPPALPLPTQHLITSGTTKNCIRLRGLPYEAMVEHILHFLDDFAKHIIYQGV 578
            |                     |...:....|.||.:|.||::.....:..|..||:  ::...:
Mouse   390 S---------------------QEGFSGSGQKLCIYIRNLPFDVTKGEVQKFFADFS--LVEDDI 431

  Fly   579 HMVINAQGQPSGEAFIQMDLEESA----RLCAQR-----------RHNHYMMFGKKYRYI---EV 625
            :::.:.:|...|||.::...||.|    ||..||           .......||.|..::   ..
Mouse   432 YLLCDDKGVGLGEALVRFKSEEQAMKAERLNRQRFLGIEVLLRLISEEQMQEFGIKSSWLSNERT 496

  Fly   626 FQCS----GDDMNMVLN 638
            ..||    |||.:.:.:
Mouse   497 QACSRSHDGDDCSCLFD 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fus	NP_524691.1	DnaQ_like_exo	13..194	CDD:299142
		RRM1_Fusilli	280..359	CDD:241182	28/74 (38%)
		RRM2_Fusilli	363..462	CDD:241185	25/128 (20%)
		RRM3_Fusilli	545..629	CDD:241187	23/101 (23%)
Rbm12b2	NP_001343491.1	RRM_SF	2..80	CDD:418427
		RRM2_RBM12B	152..237	CDD:410140	28/79 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	237..277		4/39 (10%)
		RRM_SF	283..362	CDD:418427	21/86 (24%)
		RRM	<367..562	CDD:223796	37/188 (20%)
		RRM4_RBM12B	401..476	CDD:410142	19/76 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	546..572
		PTZ00465	<590..>690	CDD:185644
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	621..643
		RRM_SF	760..834	CDD:418427
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845686
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840