DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fus and Hnrnpf

DIOPT Version :9

Sequence 1:	NP_524691.1	Gene:	fus / 44095	FlyBaseID:	FBgn0023441	Length:	967	Species:	Drosophila melanogaster
Sequence 2:	NP_001032362.1	Gene:	Hnrnpf / 64200	RGDID:	620366	Length:	415	Species:	Rattus norvegicus

Alignment Length:	472	Identity:	122/472 - (25%)
Similarity:	198/472 - (41%)	Gaps:	130/472 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 IVRARGLPWQSSDQDIAKFFRGLNVAKG--GVALCLSPLGRRNGEALIRFVCQEHRDMALKRHKH 342
            :|:.|||||..|.:|:..|.....:..|  ||....:..||::|||.:....::...:|||:.:.
  Rat    12 VVKLRGLPWSCSIEDVQNFLSDCTIHDGVAGVHFIYTREGRQSGEAFVELESEDDVKLALKKDRE 76

  Fly   343 HIGTRYIEVYRA--SGEDFLAIAGGASNEAQAFLSKGAQVIIRMRGLPYDATAKQVLDFFTTGDT 405
            .:|.|||||:::  :..|::....|.::...|  :.|   .:|:||||:..|.::::.||:..:.
  Rat    77 SMGHRYIEVFKSHRTEMDWVLKHSGPNSADSA--NDG---FVRLRGLPFGCTKEEIVQFFSGLEI 136

  Fly   406 PPCHVLDGNEGVLFVKKPDGRATGDAFVLFANETDAPKALGRHRESIGQRYIELFRSTTAEVQQV 470
            .|       .|:.....|:|:.||:|||.||::..|.||||:|:|.||.||||:|:|:..||:
  Rat   137 VP-------NGITLPVDPEGKITGEAFVQFASQELAEKALGKHKERIGHRYIEVFKSSQEEVR-- 192

  Fly   471 LNRSMDPKNYESGGGHSQPPLIAQLPTMQLP--------------LLPQVG-------------- 507
                          .:|.|||  :..::|.|              ::.|.|
  Rat   193 --------------SYSDPPL--KFMSVQRPGPYDRPGTARRYIGIVKQAGLDRMRSGAYSAGYG 241

  Fly   508 -----------------------AHSLS----HSLGASPANLCPPVPPPALPLPTQHLITSGTTK 545
                                   ::.||    |..|.|                  ......||.
  Rat   242 GYEEYSGLSDGYGFTTDLFGRDLSYCLSGMYDHRYGDS------------------EFTVQSTTG 288

  Fly   546 NCIRLRGLPYEAMVEHILHFLDDFAKHIIYQGVHMVINAQGQPSGEAFIQMDL-EESARLCAQRR 609
            :|:.:|||||:|....|.:|......    ..||:.|...|:.:|||.::... ||:....::.|
  Rat   289 HCVHMRGLPYKATENDIYNFFSPLNP----VRVHIEIGPDGRVTGEADVEFATHEEAVAAMSKDR 349

  Fly   610 HNHYMMFGKKYRYIEVFQCSGDDMNMVLNGGLASPVAQPPPPHLGHAHKQQSLLAATTGMFSSAG 674
            .|      .::||||:|..|....:   ||..:|.|.|    .:|.:..|     ||.....|..
  Rat   350 AN------MQHRYIELFLNSTTGAS---NGAYSSQVMQ----GMGVSAAQ-----ATYSGLESQS 396

  Fly   675 QSPTTVAAGTAQSPLGG 691
            .|....|..:.|:.:||
  Rat   397 VSGCYGAGYSGQNSMGG 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fus	NP_524691.1	DnaQ_like_exo	13..194	CDD:299142
		RRM1_Fusilli	280..359	CDD:241182	26/82 (32%)
		RRM2_Fusilli	363..462	CDD:241185	36/98 (37%)
		RRM3_Fusilli	545..629	CDD:241187	25/84 (30%)
Hnrnpf	NP_001032362.1	RRM1_hnRNPH_hnRNPH2_hnRNPF	10..88	CDD:410128	26/75 (35%)
		Interaction with RNA. /evidence=ECO:0000250	81..86		4/4 (100%)
		RRM2_hnRNPH_hnRNPH2_hnRNPF	103..192	CDD:410130	37/100 (37%)
		Interaction with RNA. /evidence=ECO:0000250	179..184		4/4 (100%)
		zf-RNPHF	255..290	CDD:369688	7/52 (13%)
		RRM3_hnRNPH_CRSF1_like	289..363	CDD:409929	25/83 (30%)
		Interaction with RNA. /evidence=ECO:0000250	355..360		4/4 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349089
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4211
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D392876at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750