Protein Alignment fus and Hnrnph2

DIOPT Version :10

• Sequence 1: NP_524691.1
• Gene: fus / 44095
• FlyBaseID: FBgn0023441
• Length: 967
• Species: Drosophila melanogaster
• Sequence 2: NP_063921.1
• Gene: Hnrnph2 / 56258
• MGIID: 1201779
• Length: 449
• Species: Mus musculus
• Alignment Length: 519
• Identity: 127/519 - (24%)
• Similarity: 204/519 - (39%)
• Gaps: 149/519 - (28%)

  Fly   280 IVRARGLPWQSSDQDIAKFFRGLNVAKG--GVALCLSPLGRRNGEALIRFVCQEHRDMALKRHKH 342
            :|:.|||||..|.:::.:||....:..|  ||....:..||.:|||.:....::...:|||:.:.
Mouse    12 VVKVRGLPWSCSAEEVMRFFSDCKIQNGTSGVRFIYTREGRPSGEAFVELESEDEVKLALKKDRE 76

  Fly   343 HIGTRYIEVYRASGEDFLAIAGGASNEAQAFLSKGAQVIIRMRGLPYDATAKQVLDFFTTGDTPP 407
            .:|.||:||::::..:...:.......:....:.|   .:|:||||:..:.::::.||:..:..|
Mouse    77 TMGHRYVEVFKSNSVEMDWVLKHTGPNSPDTANDG---FVRLRGLPFGCSKEEIVQFFSGLEIVP 138

  Fly   408 CHVLDGNEGVLFVKKPDGRATGDAFVLFANETDAPKALGRHRESIGQRYIELFRSTTAEVQQVLN 472
                   .|:.......||:||:|||.||::..|.|||.:|:|.||.||||:|:|:.|||:.
Mouse   139 -------NGMTLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRT--- 193

  Fly   473 RSMDPKNYESGGGHSQPPLIAQLPTMQLP-LLPQVGAHSLSHSLGASPA---------------- 520
                         |..||  .:|.|||.| ...:.||....:|:|....
Mouse   194 -------------HYDPP--RKLMTMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGGYGGY 243

  Fly   521 ---------------------NLCPPVPPPALPLPTQHLITSG------TTKNCIRLRGLPYEAM 558
                                 |.|       ....:.|....|      ||.:|:.:|||||.|.
Mouse   244 DDYGGYNDGYGFGSDRFGRDLNYC-------FSGMSDHRYGDGGSSFQSTTGHCVHMRGLPYRAT 301

  Fly   559 VEHILHFLDDFAKHIIYQGVHMVINAQGQPSGEAFIQMDLEESARLCAQRRHNHYMMFGKKYRYI 623
            ...|.:|......    ..||:.|...|:.:|||.::....|.| :.|..:....|    ::||:
Mouse   302 ENDIYNFFSPLNP----MRVHIEIGPDGRVTGEADVEFATHEDA-VAAMAKDKANM----QHRYV 357

  Fly   624 EVFQCSGDDMNMVLNGGLASPVAQPPPPHLGHAHKQQSLLAATTGMFSSAGQSPTTVAAGTAQSP 688
            |:|          ||                                |:||.|
Mouse   358 ELF----------LN--------------------------------STAGTS------------ 368

  Fly   689 LGGTHTHTHPH--SHAHAHATGHAHAAAAAAHHGLSASSAMLPGLSAAASASGLASFMSAGQQS 750
             ||.:.|::..  .::.|.|:|.|:.:......|||..|:.  |..|:...||.......||.|
Mouse   369 -GGAYDHSYVELFLNSTAGASGGAYGSQMMGGMGLSNQSSY--GGPASQQLSGGYGGGYGGQSS 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fus	NP_524691.1	DnaQ_like_exo	13..194	CDD:447876
		RRM1_Fusilli	280..359	CDD:241182	25/80 (31%)
		RRM2_Fusilli	363..462	CDD:410137	32/98 (33%)
		RRM3_Fusilli	545..629	CDD:241187	24/83 (29%)
Hnrnph2	NP_063921.1	RRM1_hnRNPH_hnRNPH2_hnRNPF	10..88	CDD:410128	25/75 (33%)
		RRM2_hnRNPH_hnRNPH2_hnRNPF	103..192	CDD:410130	35/98 (36%)
		2 X 16 AA Gly-rich approximate repeats	234..433		54/269 (20%)
		zf-RNPHF	257..290	CDD:429823	6/39 (15%)
		RRM3_hnRNPH_hnRNPH2_hnRNPF	289..364	CDD:410133	26/125 (21%)
		2 X 19 AA perfect repeats	354..392		16/92 (17%)