DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fus and esrp1

DIOPT Version :9

Sequence 1:	NP_524691.1	Gene:	fus / 44095	FlyBaseID:	FBgn0023441	Length:	967	Species:	Drosophila melanogaster
Sequence 2:	XP_005158084.1	Gene:	esrp1 / 560190	ZFINID:	ZDB-GENE-070112-1732	Length:	718	Species:	Danio rerio

Alignment Length:	826	Identity:	310/826 - (37%)
Similarity:	423/826 - (51%)	Gaps:	191/826 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PEHVVSLYIATCGQNGSGLGSDEKEIILLVFVLLEVSTGQIVGTKQILVRPDGYFIKDRTISSSS 68
            |:::|.|:..|.|.:|..||||||||:.||:.:::::|.:.....::||:||...:.:
Zfish     5 PDYLVLLFTTTSGASGDKLGSDEKEIVQLVWQVVDLATKKAGQVNELLVKPDHIELSE------- 62

  Fly    69 DNSSVTNNTASSPPLAIGDANNGSGSTSGNGNSLENGSELILPIAEAQAAGKPLSEAIEEFDAYL 133
                              :....||.|          .|.:.|:       .||..||::.:.
Zfish    63 ------------------ECQELSGLT----------DEALTPV-------DPLEVAIDQLNQ-- 90

  Fly   134 RSLSLHDT----EIKLVTDGQLPLRQCLHREASAKDVELPAYYNRFSDLRKEFLRYKSGDLARAL 194
            |..:..||    ...|.|||||.:||.||.|||:|::.||..:..|.||||||.:....:
Zfish    91 RLCAEVDTGAGNTFYLCTDGQLHVRQVLHPEASSKNILLPDCFFSFFDLRKEFKKEFPSE----- 150

  Fly   195 VPVKDVKKMLQAPTLPMPQSIAEMLGELNI---SSVEDNDFYIRESRDMVTVIQTLLQ--AGHKF 254
            |.:||:             ::..|...||:   ||:  :.|...:.:.||.::..|:.  ..|:|
Zfish   151 VKLKDL-------------NLQVMADHLNVAVDSSL--HAFTAYKVQQMVDIVLALISEPTCHEF 200

  Fly   255 AANELVNLVLEPGICSIDDEVDGNCIVRARGLPWQSSDQDIAKFFRGLNVAKGGVALCLSPLGRR 319
            ...|.||...|.|.||..:.||.|.::|||||||||||||||:||||||:||||.||||:..|||
Zfish   201 TFPEKVNEKFETGTCSKMERVDDNTVIRARGLPWQSSDQDIARFFRGLNIAKGGAALCLNAQGRR 265

  Fly   320 NGEALIRFVCQEHRDMALKRHKHHIGTRYIEVYRASGEDFLAIAGGASNEAQAFLSKGAQVIIRM 384
            |||||:||..:||||:||:|||||:|.||||||:|:|||||.||||.|||..:|||:..|:|:||
Zfish   266 NGEALVRFESEEHRDLALQRHKHHMGGRYIEVYKATGEDFLKIAGGTSNEVASFLSRENQIIVRM 330

  Fly   385 RGLPYDATAKQVLDFFTTGDTPPCHVLDGNEGVLFVKKPDGRATGDAFVLFANETDAPKALGRHR 449
            ||||::|||:|||.||    :|.|.|.||:||:|||:.||||.||||||||:.|..|..||.:|:
Zfish   331 RGLPFNATAEQVLQFF----SPACPVTDGSEGILFVRFPDGRPTGDAFVLFSCEEHAQNALKKHK 391

  Fly   450 ESIGQRYIELFRSTTAEVQQVLNRSMDPKNYESGGGHSQPPLIAQLPTMQLPLLPQVGAHSLSHS 514
            :.:|:||||||:||.||||||||:            :|..|||...|:   |:|..|
Zfish   392 DMLGKRYIELFKSTAAEVQQVLNK------------YSSAPLIPVAPS---PILSVV-------- 433

  Fly   515 LGASPANLCPPVPPPALPLPTQHLITSGTTKNCIRLRGLPYEAMVEHILHFLDDFAKHIIYQGVH 579
                       .||..:|   |.....| .::|:|||||||:|.::.||.||.::...|...|||
Zfish   434 -----------APPTFVP---QTAAVPG-VRDCVRLRGLPYDASIQDILVFLGEYGADIKTHGVH 483

  Fly   580 MVINAQGQPSGEAFIQMDLEESARLCAQRRHNHYMMFGKKYRYIEVFQCSGDDMNMVLNG----- 639
            ||:|.||:|||||||||...|.|.|.|||.|...|    |.||:|||.||..::|:||.|
Zfish   484 MVLNHQGRPSGEAFIQMRSAERAFLAAQRCHKRSM----KERYVEVFACSAQEVNIVLMGGTLNR 544

  Fly   640 -GLASP------VAQP----------------------------------------PPPHLGHAH 657
             ||:.|      ::.|                                        ||||....:
Zfish   545 SGLSPPPCKLRRLSPPSYTFPHGAPVLPAGAVLPAGAVLPVESAGIYPSQFLLGPRPPPHTTTFY 609

  Fly   658 KQQSLLAAT-TGMFSSAGQSPTTVA-AGTAQSPLGGTHTHTHP--------HSHAHAHATGHAHA 712
            ...:.|... |..:.|...||:.:: ..|..:|..|:.....|        |:|:||:..|
Zfish   610 PASNTLYMNYTTYYPSPPGSPSNISYFPTGHTPSAGSVLSAQPTALIRMQGHAHSHAYNNG---- 670

  Fly   713 AAAAAHHGLSASSAMLPGLSAA--ASASGLASFMSAGQQSAAAAAH 756
                ....||......||.|.|  ...|.|::....|.|:....|:
Zfish   671 ----VKEILSMVQGYQPGNSDAFVTFPSMLSAKQPIGDQTVGGGAY 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fus	NP_524691.1	DnaQ_like_exo	13..194	CDD:299142	53/184 (29%)
		RRM1_Fusilli	280..359	CDD:241182	60/78 (77%)
		RRM2_Fusilli	363..462	CDD:241185	59/98 (60%)
		RRM3_Fusilli	545..629	CDD:241187	45/83 (54%)
esrp1	XP_005158084.1	DnaQ_like_exo	7..174	CDD:299142	63/230 (27%)
		RRM1_ESRP1	221..305	CDD:241180	63/83 (76%)
		RRM	<272..502	CDD:223796	140/271 (52%)
		RRM_SF	310..416	CDD:302621	68/121 (56%)
		RRM3_ESRP1_ESRP2	449..529	CDD:241186	45/83 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590304
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1365
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	458	1.000	Inparanoid score	I1550
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003476
OrthoInspector	1	1.000	-	-		otm25307
orthoMCL	1	0.900	-	-		OOG6_104528
Panther	1	1.100	-	-	O	PTHR13976
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2832
SonicParanoid	1	1.000	-	-		X2364
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.780