DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fus and Esrp1

DIOPT Version :9

Sequence 1:	NP_524691.1	Gene:	fus / 44095	FlyBaseID:	FBgn0023441	Length:	967	Species:	Drosophila melanogaster
Sequence 2:	XP_006237938.1	Gene:	Esrp1 / 500409	RGDID:	1560481	Length:	681	Species:	Rattus norvegicus

Alignment Length:	774	Identity:	304/774 - (39%)
Similarity:	397/774 - (51%)	Gaps:	173/774 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PEHVVSLYIATCGQNGSGLGSDEKEIILLVFVLLEVSTGQIVGTKQILVRPDGYFIKDRTISSSS 68
            |:::|.|:..|.|..|:.|||||||:|||::.:::::..::....::|||||..   :.|.....
  Rat     5 PDYLVVLFGITAGATGAKLGSDEKELILLLWKVVDLANKKVGQLHEVLVRPDQL---ELTEDCKE 66

  Fly    69 DNSSVTNNTASSPPLAIGDANNGSGSTSGNGNSLENGSELILPIAEAQAAGKPLSEAIEEFDAYL 133
            :......|.:|:|                                       .|.:|:.:|:
  Rat    67 ETKIDAENLSSAP---------------------------------------QLDQALRQFN--- 89

  Fly   134 RSLSLH-----DTEIKLVTDGQLPLRQCLHREASAKDVELPAYYNRFSDLRKEFLRYKSGDLARA 193
            :|:|..     .|...|.|||||.:||.||.|||.|:|.||..:..|.||||||.:...|.
  Rat    90 QSVSNELNIGVGTSFCLCTDGQLHVRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGS---- 150

  Fly   194 LVPVKDVKKMLQAPTLPMPQSIAEMLGELNISSVEDNDFYIR----ESRDMVTVIQTLLQA--GH 252
                .|:.|:          .:|.|...||.   |.||...|    :..||..:|..::..  .|
  Rat   151 ----PDLDKL----------DVAAMAESLNF---EKNDSMSRYGASQVEDMGNIILAMISEPYNH 198

  Fly   253 KFAANELVNLVLEPGICSIDDEVDGNCIVRARGLPWQSSDQDIAKFFRGLNVAKGGVALCLSPLG 317
            :|:..|.||...|.|.||..:.:|||.:||||||||||||||||:||:|||:||||.||||:..|
  Rat   199 RFSDPERVNYKFESGTCSKTELIDGNTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQG 263

  Fly   318 RRNGEALIRFVCQEHRDMALKRHKHHIGTRYIEVYRASGEDFLAIAGGASNEAQAFLSKGAQVII 382
            |||||||:|||.:||||:||:|||||:||||||||:|:|||||.||||.|||...||||..|||:
  Rat   264 RRNGEALVRFVSEEHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIV 328

  Fly   383 RMRGLPYDATAKQVLDFFTTGDTPPCHVLDGNEGVLFVKKPDGRATGDAFVLFANETDAPKALGR 447
            ||||||:.|||::|:.||    ...|.:..|.||:|||..||||.|||||||||.|..|..||.:
  Rat   329 RMRGLPFTATAEEVVAFF----GQHCPITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRK 389

  Fly   448 HRESIGQRYIELFRSTTAEVQQVLNRSMDPKNYESGGGHSQPPLIAQLPTMQ-LPLLPQVGAHSL 511
            |::.:|:|||||||||.|||||||||            .|..||| .|||.. :|:|||
  Rat   390 HKDLLGKRYIELFRSTAAEVQQVLNR------------FSSAPLI-PLPTAPIIPVLPQ------ 435

  Fly   512 SHSLGASPANLCPPVPPPALPLPTQHLITSGTTKNCIRLRGLPYEAMVEHILHFLDDFAKHIIYQ 576
                     ...||.                ..::|:|||||||.|.:|.||.||.:|:..|...
  Rat   436 ---------QFVPPT----------------NVRDCVRLRGLPYAATIEDILDFLGEFSTDIRTH 475

  Fly   577 GVHMVINAQGQPSGEAFIQMDLEESARLCAQRRHNHYMMFGKKYRYIEVFQCSGDDMNMVLNGGL 641
            |||||:|.||:|||:|||||...:.|.:.||:.|...|    |.||:||||||.::||.||.||.
  Rat   476 GVHMVLNHQGRPSGDAFIQMKSTDRAFMAAQKYHKKTM----KDRYVEVFQCSAEEMNFVLMGGT 536

  Fly   642 ASPVAQPPPP--------------------HLGHAHKQQSLLAATTGMFSSAGQSPTTVAAGTAQ 686
            .:.....|||                    ....|..|.|||.           :|..:...||.
  Rat   537 LNRNGLSPPPCKLPCLSPPSYTFPAPAAVIPTEAAIYQPSLLL-----------NPRALQPSTAY 590

  Fly   687 SPLGG----THTHTHPHSHAHAHATGHAHAAAAAAHHGLSASSAMLPGLSAAASASGLA 741
            .|.|.    .:|..:|......::.|:...||..        |::.|.........|||
  Rat   591 YPAGTQLFMNYTAYYPSPPGSPNSLGYFPTAANL--------SSVPPQPGTVVRMQGLA 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fus	NP_524691.1	DnaQ_like_exo	13..194	CDD:299142	53/185 (29%)
		RRM1_Fusilli	280..359	CDD:241182	62/78 (79%)
		RRM2_Fusilli	363..462	CDD:241185	57/98 (58%)
		RRM3_Fusilli	545..629	CDD:241187	44/83 (53%)
Esrp1	XP_006237938.1	DnaQ_like_exo	29..168	CDD:299142	50/204 (25%)
		RRM1_ESRP1	221..305	CDD:241180	65/83 (78%)
		RRM	<285..473	CDD:223796	117/235 (50%)
		RRM2_ESRP1	310..418	CDD:241183	68/123 (55%)
		RRM3_ESRP1_ESRP2	444..524	CDD:241186	44/83 (53%)
		RRM	<446..>520	CDD:223796	40/77 (52%)
		RRM_SF	634..>672	CDD:302621	3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349083
Domainoid	1	1.000	448	1.000	Domainoid score	I500
eggNOG	1	0.900	-	-		E1_KOG1365
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	448	1.000	Inparanoid score	I1572
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003476
OrthoInspector	1	1.000	-	-		otm46381
orthoMCL	1	0.900	-	-		OOG6_104528
Panther	1	1.100	-	-	O	PTHR13976
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2364
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.750