DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fus and HNRNPF

DIOPT Version :9

Sequence 1:	NP_524691.1	Gene:	fus / 44095	FlyBaseID:	FBgn0023441	Length:	967	Species:	Drosophila melanogaster
Sequence 2:	NP_001091674.1	Gene:	HNRNPF / 3185	HGNCID:	5039	Length:	415	Species:	Homo sapiens

Alignment Length:	455	Identity:	125/455 - (27%)
Similarity:	199/455 - (43%)	Gaps:	96/455 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 IVRARGLPWQSSDQDIAKFFRGLNVAKG--GVALCLSPLGRRNGEALIRFVCQEHRDMALKRHKH 342
            :|:.|||||..|.:|:..|.....:..|  ||....:..||::|||.:....::...||||:.:.
Human    12 VVKLRGLPWSCSVEDVQNFLSDCTIHDGAAGVHFIYTREGRQSGEAFVELGSEDDVKMALKKDRE 76

  Fly   343 HIGTRYIEVYRA--SGEDFLAIAGGASNEAQAFLSKGAQVIIRMRGLPYDATAKQVLDFFTTGDT 405
            .:|.|||||:::  :..|::....|.::...|  :.|   .:|:||||:..|.::::.||:..:.
Human    77 SMGHRYIEVFKSHRTEMDWVLKHSGPNSADSA--NDG---FVRLRGLPFGCTKEEIVQFFSGLEI 136

  Fly   406 PPCHVLDGNEGVLFVKKPDGRATGDAFVLFANETDAPKALGRHRESIGQRYIELFRSTTAEV--- 467
            .|       .|:.....|:|:.||:|||.||::..|.||||:|:|.||.||||:|:|:..||
Human   137 VP-------NGITLPVDPEGKITGEAFVQFASQELAEKALGKHKERIGHRYIEVFKSSQEEVRSY 194

  Fly   468 ------------------------------QQVLNRSMDPKNYESG-GGHSQPPLIAQLPTMQLP 501
                                          |..|.| |.|..|.:| ||:.:...::........
Human   195 SDPPLKFMSVQRPGPYDRPGTARRYIGIVKQAGLER-MRPGAYSTGYGGYEEYSGLSDGYGFTTD 258

  Fly   502 LLPQVGAHSLS----HSLGASPANLCPPVPPPALPLPTQHLITSGTTKNCIRLRGLPYEAMVEHI 562
            |..:..::.||    |..|.|                  ......||.:|:.:|||||:|....|
Human   259 LFGRDLSYCLSGMYDHRYGDS------------------EFTVQSTTGHCVHMRGLPYKATENDI 305

  Fly   563 LHFLDDFAKHIIYQGVHMVINAQGQPSGEAFIQMDL-EESARLCAQRRHNHYMMFGKKYRYIEVF 626
            .:|......    ..||:.|...|:.:|||.::... ||:....::.|.|      .::||||:|
Human   306 YNFFSPLNP----VRVHIEIGPDGRVTGEADVEFATHEEAVAAMSKDRAN------MQHRYIELF 360

  Fly   627 QCSGDDMNMVLNGGLASPVAQPPPPHLGHAHKQQSLLAATTGMFSSAGQSPTTVAAGTAQSPLGG 691
            ..|....:   ||..:|.|.|    .:|.:..|     ||.....|...|....|..:.|:.:||
Human   361 LNSTTGAS---NGAYSSQVMQ----GMGVSAAQ-----ATYSGLESQSVSGCYGAGYSGQNSMGG 413

Fly 692 691
Human 414 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fus	NP_524691.1	DnaQ_like_exo	13..194	CDD:299142
		RRM1_Fusilli	280..359	CDD:241182	27/82 (33%)
		RRM2_Fusilli	363..462	CDD:241185	36/98 (37%)
		RRM3_Fusilli	545..629	CDD:241187	25/84 (30%)
HNRNPF	NP_001091674.1	RRM1_hnRNPH_hnRNPH2_hnRNPF	10..88	CDD:410128	27/75 (36%)
		Interaction with RNA	81..86		4/4 (100%)
		RRM2_hnRNPH_hnRNPH2_hnRNPF	103..192	CDD:410130	37/100 (37%)
		Interaction with RNA	179..184		4/4 (100%)
		zf-RNPHF	255..290	CDD:369688	8/52 (15%)
		RRM3_hnRNPH_CRSF1_like	289..363	CDD:409929	25/83 (30%)
		Interaction with RNA	355..360		4/4 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155213
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4211
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D392876at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.750