DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fus and Esrp2

DIOPT Version :9

Sequence 1:	NP_524691.1	Gene:	fus / 44095	FlyBaseID:	FBgn0023441	Length:	967	Species:	Drosophila melanogaster
Sequence 2:	XP_038953670.1	Gene:	Esrp2 / 307810	RGDID:	1310855	Length:	726	Species:	Rattus norvegicus

Alignment Length:	887	Identity:	326/887 - (36%)
Similarity:	422/887 - (47%)	Gaps:	207/887 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PEHVVSLYIATCGQNGSGLGSDEKEIILLVFVLLEVSTGQIVGTKQILVRPDGYFIKDRTISSSS 68
            |:.:|.|:.||.|..|..|||||.::||||:.::|..:.|:....:.|||.:.
  Rat    27 PQSLVVLFGATAGALGPDLGSDETDLILLVWQVVEPRSRQVGTLHKSLVRAEA------------ 79

  Fly    69 DNSSVTNNTASSPPLAIGDANNGSGSTSGNGNSLENGSELILPIAEAQAAGKPLSEAIEEFDAYL 133
                    .|.||     .....||.:                 |::.|..:.|.:.:::|...:
  Rat    80 --------AALSP-----QCREASGLS-----------------ADSLARAESLDKVLQQFSQLV 114

  Fly   134 RS--LSLHDTEIKLVTDGQLPLRQCLHREASAKDVELPAYYNRFSDLRKEF-LRYKSGDLARALV 195
            ..  ..|......|.||||..|||.||.|||.|::.||..:..|.|||:|| :::.|...||.|.
  Rat   115 SGDVALLGGGPYVLCTDGQQLLRQVLHPEASRKNLVLPDTFFSFYDLRREFHVQHPSTCSARDLT 179

  Fly   196 PVKDVKKMLQAPTLPMPQSIAEMLGELNISSVEDNDFYIRESRDMVTVIQTLLQA--GHKFAANE 258
                            ..::|:.|| |...:.|| ||.:.|.:.||.||..||:.  ||.|:..|
  Rat   180 ----------------VGTMAQDLG-LETDATED-DFGVWEVKTMVAVILHLLEGPNGHLFSKPE 226

  Fly   259 LVNLVLEPGICSID---------DEVDGNCIVRARGLPWQSSDQDIAKFFRGLNVAKGGVALCLS 314
            :|....|.|.||..         |.||...:||||||||||||||:|:||:|||:|:|||||||:
  Rat   227 VVKQKYETGPCSDPVPCPHSSKADVVDNETVVRARGLPWQSSDQDVARFFKGLNIARGGVALCLN 291

  Fly   315 PLGRRNGEALIRFVCQEHRDMALKRHKHHIGTRYIEVYRASGEDFLAIAGGASNEAQAFLSKGAQ 379
            ..|||||||||||...|.||:||:|||||:|.||||||:|:||:|:.||||.|.|...|||:..|
  Rat   292 AQGRRNGEALIRFEDSEQRDLALQRHKHHMGVRYIEVYKATGEEFVKIAGGTSLEVARFLSREDQ 356

  Fly   380 VIIRMRGLPYDATAKQVLDFFTTGDTPPCHVLDGNEGVLFVKKPDGRATGDAFVLFANETDAPKA 444
            ||:|:||||:.|....||||.    .|.|.|..|.:|:|||:.||||.|||||.|||.|..|..|
  Rat   357 VILRLRGLPFSAGPADVLDFL----GPECPVTGGVDGLLFVRHPDGRPTGDAFALFACEELAQAA 417

  Fly   445 LGRHRESIGQRYIELFRSTTAEVQQVLNRSMDPKNYESGGGHSQPPLIAQLPTMQLPLLPQVGAH 509
            |.||:..:|:|||||||||.|||||||||            ::..||   |||:..||||
  Rat   418 LRRHKGMLGKRYIELFRSTAAEVQQVLNR------------YAASPL---LPTLTAPLLP----- 462

  Fly   510 SLSHSLGASPANLCPPVPPPALPLPTQHLITSGTTKNCIRLRGLPYEAMVEHILHFLDDFAKHII 574
                                 :|.|    :..||.::|:|||||||.|.:|.||.||.:.|..|.
  Rat   463 ---------------------IPFP----LAGGTGRDCVRLRGLPYTATIEDILSFLGEAAADIR 502

  Fly   575 YQGVHMVINAQGQPSGEAFIQMDLEESARLCAQRRHNHYMMFGKKYRYIEVFQCSGDDMNMVLNG 639
            ..|||||:|.||:|||:|||||...|.|...|||.|...|    |.||:||..||.::|:.||.|
  Rat   503 PHGVHMVLNQQGRPSGDAFIQMMSVERALAAAQRCHKKVM----KERYVEVVPCSTEEMSRVLMG 563

  Fly   640 GLASPVAQPPPPHLGHAHKQQSLLAATTGMFSSAGQSPTTVAAGTAQSPLGGTHTHTHPHSHAHA 704
            |..|.....|||     .|...|             ||.|.|...|...|..|.|
  Rat   564 GSLSRSGLSPPP-----CKLPCL-------------SPPTYATFQASPALIPTET---------- 600

  Fly   705 HATGHAHAAAAAAHHGLSASSAMLPGLSAAASASGLASFMSAGQQSAAAAAHSAASLQNAAVALA 769
                          ..|..|||:||.....|:|:.||.:.....|   ...:..|...:..|:..
  Rat   601 --------------TALYPSSALLPAARVPAAATPLAYYPGPATQ---LYMNYTAYYPSPPVSPT 648

  Fly   770 PQGYALNPFSLPPPGSAAAAAASTPALLAQQQAQFIAQQSLLVRQQAAAAALAAEQQQQQQQQQQ 834
            ..||    .:.||     .|.||||       ...::|...|||.|...
  Rat   649 TVGY----LTTPP-----TALASTP-------TSMLSQPGALVRMQGVP---------------- 681

  Fly   835 LYASAMLQQHPLYLQQQQQQQQLYASAMLQQGQPQFVLMQRP 876
             |.:.|.....:: |..|.....||: ::..|.|...::|.|
  Rat   682 -YTAGMKDLLSVF-QAYQLAPDDYAT-LVPVGDPPRTVLQAP 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fus	NP_524691.1	DnaQ_like_exo	13..194	CDD:299142	53/183 (29%)
		RRM1_Fusilli	280..359	CDD:241182	59/78 (76%)
		RRM2_Fusilli	363..462	CDD:241185	54/98 (55%)
		RRM3_Fusilli	545..629	CDD:241187	44/83 (53%)
Esrp2	XP_038953670.1	DnaQ_like_exo	<82..214	CDD:415823	48/171 (28%)
		RRM_SF	247..339	CDD:418427	63/91 (69%)
		RRM_SF	341..447	CDD:418427	65/121 (54%)
		RRM3_ESRP1_ESRP2	473..553	CDD:410138	44/83 (53%)
		PHA03247	<564..687	CDD:223021	43/200 (22%)
		RRM_SF	673..>702	CDD:418427	8/46 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349085
Domainoid	1	1.000	448	1.000	Domainoid score	I500
eggNOG	1	0.900	-	-		E1_KOG1365
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32617
Inparanoid	1	1.050	448	1.000	Inparanoid score	I1572
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003476
OrthoInspector	1	1.000	-	-		otm46381
orthoMCL	1	0.900	-	-		OOG6_104528
Panther	1	1.100	-	-	LDO	PTHR13976
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2364
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.750