DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fus and Grsf1

DIOPT Version :9

Sequence 1:	NP_524691.1	Gene:	fus / 44095	FlyBaseID:	FBgn0023441	Length:	967	Species:	Drosophila melanogaster
Sequence 2:	NP_848815.2	Gene:	Grsf1 / 231413	MGIID:	106479	Length:	479	Species:	Mus musculus

Alignment Length:	444	Identity:	124/444 - (27%)
Similarity:	197/444 - (44%)	Gaps:	90/444 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 LQAPTLPMPQSIAEMLGELNISSVEDNDFYIRESRDMVTVIQTLLQAGHKFAANELVNLVLEPGI 268
            |:||.  .|:|:|...|.....|.|....|:.:                   ...|....|.|.
Mouse    97 LRAPL--FPRSLAAAAGPARGYSQESKTTYLED-------------------LPPLPEYELSPS- 139

  Fly   269 CSIDDEVDGNCIVRARGLPWQSSDQDIAKFFRGLNV--AKGGVALCLSPLGRRNGEALIRFVCQE 331
             .:.||||...::||:||||..:.:|:..||....:  ::.|:...|:..|:|.|:|||....::
Mouse   140 -KLGDEVDDVYLIRAQGLPWSCTVEDVLNFFSDCRIRNSENGIHFLLNRDGKRRGDALIEMESEQ 203

  Fly   332 HRDMALKRHKHHIGTRYIEVYRASGEDFLAIAGGASNEAQAFLSKGAQVIIRMRGLPYDATAKQV 396
            ....||::|:.::|.||:|||..:.||..|:......:....||.|   ::|:|||||....|.:
Mouse   204 DVQKALEKHRMYMGQRYVEVYEINNEDVDALMKSLQVKPSPVLSDG---VVRLRGLPYSCNEKDI 265

  Fly   397 LDFFTTGDTPPCHVLDGNEGVLFVKKPDG-RATGDAFVLFANETDAPKALGRHRESIGQRYIELF 460
            :|||.     ..:::|    :.||....| |.||:|:|.|.....|.:||.:|||.||.||||:|
Mouse   266 VDFFA-----GLNIVD----ITFVMDYRGRRKTGEAYVQFEEPEMANQALLKHREEIGNRYIEIF 321

  Fly   461 RSTTAEVQQVLNRSMDPKNYESGGGHSQPPLIAQLPTMQLPLLPQV--GAHSLSHSLGASPA--- 520
            .|...||:..:            |.|....:.:..||..: ..|:|  ..|.::..:....|
Mouse   322 PSRRNEVRTHV------------GSHKGKKMTSSPPTKYI-TEPEVVFEEHEVNEDIRPMTAFES 373

  Fly   521 ----NLCPPVPPPALP-------LPTQHLITSGTTKNCIRLRGLPYEAMVEHILHFLDDFA--KH 572
                .| |......||       ||:.|.         :.:||||::|..:.|::|   ||  |.
Mouse   374 DKEIEL-PKEMSEKLPEAVDFGTLPSLHF---------VHMRGLPFQANAQDIINF---FAPLKP 425

  Fly   573 IIYQGVHMVINAQGQPSGEAFIQMDLEESARLCAQRRHNHYMMFGKKYRYIEVF 626
            :   .:.|..::.|:.:|||.:..|..|.|.....:..:|.     ::||||:|
Mouse   426 V---RITMEYSSSGKATGEADVHFDTHEDAVAAMLKDRSHV-----QHRYIELF 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fus	NP_524691.1	DnaQ_like_exo	13..194	CDD:299142
		RRM1_Fusilli	280..359	CDD:241182	27/80 (34%)
		RRM2_Fusilli	363..462	CDD:241185	36/99 (36%)
		RRM3_Fusilli	545..629	CDD:241187	24/84 (29%)
Grsf1	NP_848815.2	RRM1_GRSF1	148..226	CDD:241174	26/77 (34%)
		RRM	<155..325	CDD:223796	64/181 (35%)
		RRM2_GRSF1	248..321	CDD:240949	33/84 (39%)
		RRM	328..>458	CDD:223796	34/158 (22%)
		RRM3_GRSF1	400..474	CDD:241177	25/92 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845689
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4211
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740