DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fus and Esrp1

DIOPT Version :9

Sequence 1:	NP_524691.1	Gene:	fus / 44095	FlyBaseID:	FBgn0023441	Length:	967	Species:	Drosophila melanogaster
Sequence 2:	NP_918944.2	Gene:	Esrp1 / 207920	MGIID:	1917326	Length:	681	Species:	Mus musculus

Alignment Length:	759	Identity:	298/759 - (39%)
Similarity:	393/759 - (51%)	Gaps:	143/759 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PEHVVSLYIATCGQNGSGLGSDEKEIILLVFVLLEVSTGQIVGTKQILVRPDGYFIKDRTISSSS 68
            |:::|.|:..|.|..|:.|||||||:|||::.:::::..::....::|||||..   :.|.....
Mouse     5 PDYLVVLFGITAGATGAKLGSDEKELILLLWKVVDLANKKVGQLHEVLVRPDQL---ELTEDCKE 66

  Fly    69 DNSSVTNNTASSPPLAIGDANNGSGSTSGNGNSLENGSELILPIAEAQAAGKPLSEAIEEFDAYL 133
            :......|.:|:|                                       .|.:|:.:|:
Mouse    67 ETKIDAENLSSAP---------------------------------------QLDQALRQFN--- 89

  Fly   134 RSLSLH-----DTEIKLVTDGQLPLRQCLHREASAKDVELPAYYNRFSDLRKEFLRYKSGDLARA 193
            :|:|..     .|...|.|||||.:||.||.|||.|:|.||..:..|.||||||.:...|.
Mouse    90 QSVSNELNIGVGTSFCLCTDGQLHIRQILHPEASKKNVLLPECFYSFFDLRKEFKKCCPGS---- 150

  Fly   194 LVPVKDVKKMLQAPTLPMPQSIAEMLGELNISSVEDNDFY-IRESRDMVTVIQTLLQA--GHKFA 255
                .|:.|:          .:|.|...||....:....| ..:..||..:|..::..  .|:|:
Mouse   151 ----PDIDKL----------DVAAMTESLNFEKSDSVSRYGASQVEDMGNIILAMISEPYNHRFS 201

  Fly   256 ANELVNLVLEPGICSIDDEVDGNCIVRARGLPWQSSDQDIAKFFRGLNVAKGGVALCLSPLGRRN 320
            ..|.||...|.|.||..:.:|.:.:||||||||||||||||:||:|||:||||.||||:..||||
Mouse   202 DPERVNYKFESGTCSKMELIDDSTVVRARGLPWQSSDQDIARFFKGLNIAKGGAALCLNAQGRRN 266

  Fly   321 GEALIRFVCQEHRDMALKRHKHHIGTRYIEVYRASGEDFLAIAGGASNEAQAFLSKGAQVIIRMR 385
            ||||:|||.:||||:||:|||||:||||||||:|:|||||.||||.|||...||||..|||:|||
Mouse   267 GEALVRFVSEEHRDLALQRHKHHMGTRYIEVYKATGEDFLKIAGGTSNEVAQFLSKENQVIVRMR 331

  Fly   386 GLPYDATAKQVLDFFTTGDTPPCHVLDGNEGVLFVKKPDGRATGDAFVLFANETDAPKALGRHRE 450
            |||:.|||::|:.||    ...|.:..|.||:|||..||||.|||||||||.|..|..||.:|:|
Mouse   332 GLPFTATAEEVVAFF----GQHCPITGGKEGILFVTYPDGRPTGDAFVLFACEEYAQNALRKHKE 392

  Fly   451 SIGQRYIELFRSTTAEVQQVLNRSMDPKNYESGGGHSQPPLIAQLPTMQLPLLPQVGAHSLSHSL 515
            .:|:|||||||||.|||||||||            .|..||| .|||
Mouse   393 LLGKRYIELFRSTAAEVQQVLNR------------FSSAPLI-PLPT------------------ 426

  Fly   516 GASPANLCPPVPPPALPLPTQHLITSGTTKNCIRLRGLPYEAMVEHILHFLDDFAKHIIYQGVHM 580
                        ||.:|:..|..:.....::|||||||||.|.:|.||.||.:|:..|...||||
Mouse   427 ------------PPIIPVLPQQFVPPTNVRDCIRLRGLPYAATIEDILDFLGEFSTDIRTHGVHM 479

  Fly   581 VINAQGQPSGEAFIQMDLEESARLCAQRRHNHYMMFGKKYRYIEVFQCSGDDMNMVLNGG-LASP 644
            |:|.||:|||:|||||...:.|.:.||:.|...|    |.||:||||||.::||.||.|| |...
Mouse   480 VLNHQGRPSGDAFIQMKSTDRAFMAAQKYHKKTM----KDRYVEVFQCSAEEMNFVLMGGTLNRN 540

  Fly   645 VAQPPPPHLGHAHKQQSLLAATTGMFSSAGQ--------SPTTVAAGTAQSPLGG----THTHTH 697
            ...|||..|...........|.|.:..:...        :|..:...||..|.|.    .:|..:
Mouse   541 GLSPPPCKLPCLSPPSYTFPAPTAVIPTEAAIYQPSLLLNPRALQPSTAYYPAGTQLFMNYTAYY 605

  Fly   698 PHSHAHAHATGHAHAAAAAAHHGLSASSAMLPGLSAAASASGLA 741
            |......::.|:...||..        |::.|.........|||
Mouse   606 PSPPGSPNSLGYFPTAANL--------SSVPPQPGTVVRMQGLA 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fus	NP_524691.1	DnaQ_like_exo	13..194	CDD:299142	53/185 (29%)
		RRM1_Fusilli	280..359	CDD:241182	62/78 (79%)
		RRM2_Fusilli	363..462	CDD:241185	58/98 (59%)
		RRM3_Fusilli	545..629	CDD:241187	45/83 (54%)
Esrp1	NP_918944.2	DnaQ_like_exo	29..>145	CDD:299142	43/160 (27%)
		RRM1_ESRP1	221..305	CDD:241180	63/83 (76%)
		RRM	<285..473	CDD:223796	117/234 (50%)
		RRM2_ESRP1	310..418	CDD:241183	69/123 (56%)
		RRM3_ESRP1_ESRP2	444..524	CDD:241186	45/83 (54%)
		RRM	<446..>520	CDD:223796	41/77 (53%)
		RRM_SF	634..>672	CDD:302621	3/8 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845679
Domainoid	1	1.000	445	1.000	Domainoid score	I530
eggNOG	1	0.900	-	-		E1_KOG1365
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	445	1.000	Inparanoid score	I1624
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003476
OrthoInspector	1	1.000	-	-		otm44282
orthoMCL	1	0.900	-	-		OOG6_104528
Panther	1	1.100	-	-	O	PTHR13976
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2832
SonicParanoid	1	1.000	-	-		X2364
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.780