DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fus and hrpf-2

DIOPT Version :9

Sequence 1:	NP_524691.1	Gene:	fus / 44095	FlyBaseID:	FBgn0023441	Length:	967	Species:	Drosophila melanogaster
Sequence 2:	NP_741422.1	Gene:	hrpf-2 / 177398	WormBaseID:	WBGene00022253	Length:	610	Species:	Caenorhabditis elegans

Alignment Length:	723	Identity:	161/723 - (22%)
Similarity:	238/723 - (32%)	Gaps:	247/723 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   281 VRARGLPWQSSDQDIAKFFRGLNVAKGGVALCLSPLGRRNGEALIRFVCQEHRDMALKRHKHHIG 345
            :|.||||:.::::||.:||.||.:.:... :|.:  ||.||||.:.|...|....|::..:..|.
Worm    66 IRLRGLPFNATEKDIHEFFAGLTIERVKF-VCTT--GRPNGEAYVEFKNTEEAGKAMENDRKEIS 127

  Fly   346 TRYIEVYRASGEDFLAIAGGASNEAQAFLSKGAQV--IIRMRGLPYDATAKQVLDFFTTGDTPPC 408
            .|||||:....::       |..|.:.......:|  :||:||:|:......|..||...:.||.
Worm   128 NRYIEVFTVEADE-------AEFEFRPDPDSNGEVNHVIRLRGVPWSCKEDDVRKFFEGLEPPPA 185

  Fly   409 HVLDGNEGVLFVKKPDGRATGDAFVLFANETDAPKALGRHRESIGQRYIELFRSTTAEVQQV--- 470
            .::.|..|     .|..|.:|:|||.|..:..|.||:..:...:|.||:|:|.|:..|..:.
Worm   186 EIVIGGTG-----GPRSRPSGEAFVRFTTQDAAEKAMDYNNRHMGSRYVEVFMSSMVEFNRAKGG 245

  Fly   471 ---------------------------------------LNRSMDPKN---------YESGGGHS 487
                                                   .:|..|..|         |...|||.
Worm   246 GSGEYSASYERTGIRPLMSVDSGYDHGRRGGGGRYGDSSYDRGYDDYNRGSYGGRRDYGYNGGHD 310

  Fly   488 QPPLIAQLPTMQLPLLPQVGAHSLSHSLGASPANLCPPVPPPALPLPTQHLITSGTTKNCIRLRG 552
            |                  |..|.....|..|..                          :.:||
Worm   311 Q------------------GGRSDYGRGGDDPLR--------------------------VYMRG 331

  Fly   553 LPYEAMVEHILHFLDDFAKHIIYQGVHMVINAQGQPSGEAFIQMDLEESARLCAQRRHNHYMMFG 617
            |||:|....|..|......|.:..|    ||..|:|||:|..:.|.....:: |..|:|..|  |
Worm   332 LPYDADDHAIAAFFSPLRCHSVKIG----INETGRPSGDAIAEFDNYNDLQV-ALSRNNQRM--G 389

  Fly   618 KKYRYIEVFQCSGDDMNMVLNGGLASPVAQPPPPHLGHAHKQQSLLAATTGMFSSAGQSPTTVAA 682
            :  ||:|:|.          |.|...|:             ::.|...|:|..:||..:|..:..
Worm   390 R--RYVELFD----------NRGAPGPM-------------RRLLWKETSGTNASAAPAPDPILN 429

  Fly   683 GTAQSPLGGTHTHTHPHSHAHAHATGHAHAAAAAAHHGLSASSAMLPGLSAAASASGLASFMSAG 747
            |..:.  ||      |......:..|               ..||.|....:....|
Worm   430 GGRRG--GG------PPQRDSGYRAG---------------PQAMPPSYRESRDPYG-------- 463

  Fly   748 QQSAAAAAHSAASLQNAAVALAPQGYALNPFSLP---PPGSA-----AAAAASTPALLAQQQAQF 804
                               ...|:||.:.|...|   ||.||     .||....|.......|
Worm   464 -------------------PREPRGYDIEPKYEPRGIPPRSAPIRAPPAAHGRAPDTWGSYGA-- 507

  Fly   805 IAQQSLLVRQQAAAAALAAEQQQQQQQQQQLYASAMLQQHPLYLQQQQQQQQLYASAMLQQGQPQ 869
             |.......|.:||...||       .....|||              |.|..|::
Worm   508 -ASTGPSYDQSSAAGGYAA-------SWDAYYAS--------------QAQSAYSA--------- 541

  Fly   870 FVLMQRPSAAYLPPFPLSYMSAAGAASGVGVAPGAAVAGA-AAAASPSASNSSLSQSMKRSYENA 933
                 .|::.|    |.:..||.|  ||...:.||:..|| .....|..|..:.:|..:.|:.:|
Worm   542 -----EPASTY----PTAAHSAYG--SGESYSYGASAGGAYDRQREPRDSQPTWAQQQQPSHHSA 595

  Fly   934 FQQEAAGA 941
            :....|||
Worm   596 YGGWGAGA 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fus	NP_524691.1	DnaQ_like_exo	13..194	CDD:299142
		RRM1_Fusilli	280..359	CDD:241182	27/77 (35%)
		RRM2_Fusilli	363..462	CDD:241185	30/100 (30%)
		RRM3_Fusilli	545..629	CDD:241187	27/83 (33%)
hrpf-2	NP_741422.1	RRM_hnRNPH_ESRPs_RBM12_like	65..134	CDD:240700	26/70 (37%)
		RRM_hnRNPH_ESRPs_RBM12_like	158..232	CDD:240700	26/78 (33%)
		RRM_SF	326..398	CDD:388407	27/116 (23%)
		PRK07764	<400..590	CDD:236090	57/296 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4211
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D603679at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.780