DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fus and sym-2

DIOPT Version :9

Sequence 1:	NP_524691.1	Gene:	fus / 44095	FlyBaseID:	FBgn0023441	Length:	967	Species:	Drosophila melanogaster
Sequence 2:	NP_495960.2	Gene:	sym-2 / 174461	WormBaseID:	WBGene00006367	Length:	618	Species:	Caenorhabditis elegans

Alignment Length:	577	Identity:	217/577 - (37%)
Similarity:	297/577 - (51%)	Gaps:	130/577 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 DANNGSGSTSGNGNSLENGSEL------ILPIAEAQAAGKPLSEAIEEFDAYLRSLSLHDTEIKL 145
            ||||.|.|.|...:|   |||:      |.|           .:.::.||.       |.|...:
Worm    40 DANNNSTSPSSASSS---GSEISTRLVNITP-----------EDVVKFFDE-------HPTSSYI 83

  Fly   146 VTDGQLPLRQCLHREASAKDVELPAYYNRFSDLRKEFLRYKSGDLARALVPVKDVKKMLQAPTLP 210
            .|.|..|:|..|....:..::.:|...:.:.|::..:...:..|                    .
Worm    84 FTKGPEPIRHVLIPLFARNELCVPHPLHHYYDIKHLYYGNQEED--------------------G 128

  Fly   211 MPQSIAEMLGELNISSVEDNDFYIRESRDMVTVIQTLLQAGHKFAANELVNLVLEPGICSIDDEV 275
            |.|           ..:||:   :..:|.::.:...||:..|:|     ||:..:|.....|.||
Worm   129 MEQ-----------EEIEDD---VAIARAILDMDDELLEKTHQF-----VNIEYQPAPILEDQEV 174

  Fly   276 --DG-NCIVRARGLPWQSSDQDIAKFFRGLNVAKGGVALCLSPLGRRNGEALIRFVCQEHRDMAL 337
              || |.:.||||||||:||..:|:||.||::..||:|||||..||||||.|::|..||.||:||
Worm   175 GADGDNVVCRARGLPWQASDHHVAQFFAGLDIVPGGIALCLSSEGRRNGEVLVQFSSQESRDLAL 239

  Fly   338 KRHKHHIGTRYIEVYRASGEDFLAIAGGASNEAQAFLSKGAQVIIRMRGLPYDATAKQVLDFFTT 402
            |||::.:.:||||||:|..::|:.:|.|:|.||..|:|..| :|:||||||||.|..|:..||
Worm   240 KRHRNFLLSRYIEVYKAGLDEFMHVATGSSTEAMEFVSANA-IIVRMRGLPYDCTDAQIRTFF-- 301

  Fly   403 GDTPPCHVLDGNEGVLFVKKPDGRATGDAFVLFANETDAPKALGRHRESIGQRYIELFRSTTAEV 467
               .|..:.|   .:||:.:.|||.||||||.|..|.||.:.|.:||:.|||||||||:||.|||
Worm   302 ---EPLKLTD---KILFITRTDGRPTGDAFVQFETEEDAQQGLLKHRQVIGQRYIELFKSTAAEV 360

  Fly   468 QQVLNRSMDPKNYESGGGHSQPPLIAQLPTMQLPLLPQVGAHSLSHSLGASPANLCPPVPPPALP 532
            |||:.|                                      .:.:.:|||      ...|:.
Worm   361 QQVVKR--------------------------------------CNLINSSPA------VANAVE 381

  Fly   533 LPTQHLITSGTTKNCIRLRGLPYEAMVEHILHFLDDFAKHIIYQGVHMVINAQGQPSGEAFIQMD 597
            .|.:      ..|:|:|||||||||.|:||:.||.|||..:.:||||||.|.||.|||||||||.
Worm   382 APEE------KKKDCVRLRGLPYEATVQHIVTFLGDFATMVKFQGVHMVYNNQGHPSGEAFIQMI 440

  Fly   598 LEESARLCAQRRHNHYMMFGKKYRYIEVFQCSGDDMNMVLNGGLASPVAQPPPPHLG 654
            .|::|..||...||::|..|||.|||||||.|.:::|:....|....|  |||..||
Worm   441 NEQAASACAAGVHNNFMSVGKKKRYIEVFQASAEELNLHHLVGQQHQV--PPPAPLG 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fus	NP_524691.1	DnaQ_like_exo	13..194	CDD:299142	25/112 (22%)
		RRM1_Fusilli	280..359	CDD:241182	46/78 (59%)
		RRM2_Fusilli	363..462	CDD:241185	50/98 (51%)
		RRM3_Fusilli	545..629	CDD:241187	54/83 (65%)
sym-2	NP_495960.2	RRM1_ESRPs_Fusilli	182..256	CDD:240951	45/73 (62%)
		RRM2_ESRPs_Fusilli	281..355	CDD:240952	42/81 (52%)
		RRM	<282..446	CDD:223796	94/221 (43%)
		RRM3_Fusilli	388..472	CDD:241187	54/83 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167673
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1365
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32617
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003476
OrthoInspector	1	1.000	-	-		oto17516
orthoMCL	1	0.900	-	-		OOG6_104528
Panther	1	1.100	-	-	LDO	PTHR13976
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2832
SonicParanoid	1	1.000	-	-		X2364
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.730