DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fus and Hnrnph1

DIOPT Version :9

Sequence 1:	NP_524691.1	Gene:	fus / 44095	FlyBaseID:	FBgn0023441	Length:	967	Species:	Drosophila melanogaster
Sequence 2:	XP_038941022.1	Gene:	Hnrnph1 / 140931	RGDID:	620840	Length:	472	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	126/523 - (24%)
Similarity:	209/523 - (39%)	Gaps:	129/523 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   280 IVRARGLPWQSSDQDIAKFFRGLNVAKG--GVALCLSPLGRRNGEALIRFVCQEHRDMALKRHKH 342
            :|:.|||||..|..::.:||....:..|  |:....:..||.:|||.:....::...:|||:.:.
  Rat    12 VVKVRGLPWSCSADEVQRFFSDCKIQNGAQGIRFIYTREGRPSGEAFVELESEDEVKLALKKDRE 76

  Fly   343 HIGTRYIEVYRASGEDFLAIAGGASNEAQAFLSKGAQVIIRMRGLPYDATAKQVLDFFTTGDTPP 407
            .:|.||:||::::..:...:.......:....:.|   .:|:||||:..:.::::.||:..:..|
  Rat    77 TMGHRYVEVFKSNNVEMDWVLKHTGPNSPDTANDG---FVRLRGLPFGCSKEEIVQFFSGLEIVP 138

  Fly   408 CHVLDGNEGVLFVKKPDGRATGDAFVLFANETDAPKALGRHRESIGQRYIELFRSTTAEVQQVLN 472
                   .|:.......||:||:|||.||::..|.|||.:|:|.||.||||:|:|:.|||:.
  Rat   139 -------NGITLPVDFQGRSTGEAFVQFASQEIAEKALKKHKERIGHRYIEIFKSSRAEVRT--- 193

  Fly   473 RSMDPKNYESGGGHSQPPLIAQLPTMQLP-LLPQVGAHSLSHSLGASPA---------------- 520
                         |..||  .:|..||.| ...:.||....:|:|....
  Rat   194 -------------HYDPP--RKLMAMQRPGPYDRPGAGRGYNSIGRGAGFERMRRGAYGGGYGGY 243

  Fly   521 ---------------------NLCPPVPPPALPLPTQHLITSG------TTKNCIRLRGLPYEAM 558
                                 |.|       ....:.|....|      ||.:|:.:|||||.|.
  Rat   244 DDYNGYNDGYGFGSDRFGRDLNYC-------FSGMSDHRYGDGGSTFQSTTGHCVHMRGLPYRAT 301

  Fly   559 VEHILHFLDDFAKHIIYQGVHMVINAQGQPSGEAFIQMDLEESARLCAQRRHNHYMMFGKKYRYI 623
            ...|.:|......    ..||:.|...|:.:|||.::....|.| :.|..:....|    ::||:
  Rat   302 ENDIYNFFSPLNP----VRVHIEIGPDGRVTGEADVEFATHEDA-VAAMSKDKANM----QHRYV 357

  Fly   624 EVFQCSGDDMNMV--LNGGLASPVAQPPPPHLGHAHKQQSL-LAATTG---------MFSSAGQS 676
            |:|      :|..  .:||             .:.|:...| |.:|.|         |....|.|
  Rat   358 ELF------LNSTAGASGG-------------AYEHRYVELFLNSTAGASGGAYGSQMMGGMGLS 403

  Fly   677 PTTVAAGTAQSPLGGTHTHTHPHSHAHAHATGHAHAAAAAAHHGLSASSAM-----LPGLSAAAS 736
            ..:...|.|...|.|.:...:   ...:..:|:....|..:.:..|.|.|.     :.|:|:.:|
  Rat   404 NQSSYGGPASQQLSGGYGGGY---GGQSSMSGYGSQGAVNSSYYSSGSRASMGVNGMGGMSSMSS 465

  Fly   737 ASG 739
            .||
  Rat   466 MSG 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fus	NP_524691.1	DnaQ_like_exo	13..194	CDD:299142
		RRM1_Fusilli	280..359	CDD:241182	24/80 (30%)
		RRM2_Fusilli	363..462	CDD:241185	32/98 (33%)
		RRM3_Fusilli	545..629	CDD:241187	24/83 (29%)
Hnrnph1	XP_038941022.1	RRM1_hnRNPH_hnRNPH2_hnRNPF	10..88	CDD:410128	24/75 (32%)
		RRM2_hnRNPH_hnRNPH2_hnRNPF	103..192	CDD:410130	35/98 (36%)
		zf-RNPHF	255..290	CDD:369688	6/41 (15%)
		RRM3_hnRNPH_hnRNPH2_hnRNPF	289..364	CDD:410133	25/89 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4211
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D392876at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820