Protein Alignment Rs1 and HCA4

DIOPT Version :10

• Sequence 1: NP_651970.1
• Gene: Rs1 / 44087
• FlyBaseID: FBgn0021995
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_012501.1
• Gene: HCA4 / 853419
• SGDID: S000003570
• Length: 770
• Species: Saccharomyces cerevisiae
• Alignment Length: 779
• Identity: 218/779 - (27%)
• Similarity: 337/779 - (43%)
• Gaps: 165/779 - (21%)

  Fly   113 KHDNLRLREKKESKKKKKKAGEEDEEDEGEKMQFADTVEANEQITS---FYQMNLSRPLMRAIGV 174
            |.:.|...::|..::|      |||..|..|.:..   |.:.:||.   |..:.:|.|.::.:..
Yeast     3 KKNRLNTTQRKTLRQK------EDEYIENLKTKID---EYDPKITKAKFFKDLPISDPTLKGLRE 58

  Fly   175 LGYIYPTPIQASTIPVALLGRDICGCAATGTGKTAAYMLPTLERLLYRPLNNKAITRVLVLVPTR 239
            ..:|..|.|||.:|||:|.|.|:...|.||:|||.|:::|.:|:|.............|::.|||
Yeast    59 SSFIKLTEIQADSIPVSLQGHDVLAAAKTGSGKTLAFLVPVIEKLYREKWTEFDGLGALIISPTR 123

  Fly   240 ELGAQVYQVTKQLCQFTTIDVGLAIGGLDVKAQ-EAVLRQNPDIVIATPGRLIDHIKNTPSFTLD 303
            ||..|:|:|..::...|:...||.|||.|||.: |.:.|.|  |:|.||||::.|:.........
Yeast   124 ELAMQIYEVLTKIGSHTSFSAGLVIGGKDVKFELERISRIN--ILIGTPGRILQHLDQAVGLNTS 186

  Fly   304 SIEVLILDEADRMLDEYFAEQMKEIINSCCKTRQTMLFSATMSEQVKDLAAVSLD--KPIKVF-- 364
            ::::|:||||||.||..|.:.:..|:::...:|||:|||||.|:.|.|||.:||.  |.:...
Yeast   187 NLQMLVLDEADRCLDMGFKKTLDAIVSTLSPSRQTLLFSATQSQSVADLARLSLTDYKTVGTHDV 251

  Fly   365 ----VNNNQQVAFNLRQEFIRIREDKEGDREPILASLICRTFHDHCMVFVQTKKQAHRLHILLGL 425
                ||........|:|.:|.:   ...|:..||.|.|........:||:.:.||.|.::.....
Yeast   252 MDGSVNKEASTPETLQQFYIEV---PLADKLDILFSFIKSHLKCKMIVFLSSSKQVHFVYETFRK 313

  Fly   426 L--GVRAGELHGNLTQQQRLESLKKFKEEQIDVLIATDVAARGLDIVGVKTVINFVMPITTEHYI 488
            :  |:....|||...|:.|.|:|.||...|...|.||||.|||:|...|..|:....|...:.||
Yeast   314 MQPGISLMHLHGRQKQRARTETLDKFNRAQQVCLFATDVVARGIDFPAVDWVVQVDCPEDVDTYI 378

  Fly   489 HRVGRTARAGRAGIS-VSLAGEKERKIVKDIIKNAESTIKNRIIPPEIIEKYRNKLTSLEPEIQN 552
            |||||.||.|:.|.| :.|..:::...:|.:  ||      |.|.|..:...::|..|::|::|:
Yeast   379 HRVGRCARYGKKGKSLIMLTPQEQEAFLKRL--NA------RKIEPGKLNIKQSKKKSIKPQLQS 435

  Fly   553 IL--------------------------------DE--------------------------EQA 559
            :|                                ||                          |||
Yeast   436 LLFKDPELKYLGQKAFISYVRSIYVQKDKQVFKFDELPTEEFAYSLGLPGAPKIKMKGMKTIEQA 500

  Fly   560 E------RQLA--------------KTEQQLSKTER------------------KLLGQTNERRG 586
            :      ||||              |::|..:|.::                  |...|.:|...
Yeast   501 KERKNAPRQLAFLSKANEDGEVIEDKSKQPRTKYDKMFERKNQTILSEHYLNITKAQAQEDEDDD 565

  Fly   587 WFQTKQQ----REAEKDRLALTTG--DEDKASGGKGKGKTAGKRKRPEYGGDGEDGPPVKDLEAK 645
            :...|::    .|||...|.|.|.  .:.||...|....:.|...:..:..:|| ..||.:||.:
Yeast   566 FISVKRKDHEINEAELPALTLPTSRRAQKKALSKKASLASKGNASKLIFDDEGE-AHPVYELEDE 629

  Fly   646 RNKKKKEEPRKKTPEQLAKERA-MKEIEKVSLVRAKMAKLRKRPGKL-------GAATEVHRSG- 701
            ....|:.:...:..|.|.||.| |.:|:.:....||..|..|:..:|       .||.|...||
Yeast   630 EEFHKRGDAEVQKTEFLTKESAVMADIDNIDKQVAKEKKQEKKRKRLEAMRREMEAAMEEEISGD 694

  Fly   702 ASDGKPKRRGGQSAFTNDLTDVSRGGALRLRSEANRHKKMTKIAAKKKASSVKLTNKAGKNKFN 765
            ..:||.....|....::|::|    |.:   .::..|       .||||.:|..::  |.|..|
Yeast   695 EEEGKTVAYLGTGNLSDDMSD----GDM---PDSEGH-------LKKKARTVDYSH--GHNPSN 742

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rs1	NP_651970.1	SrmB	156..576	CDD:440279	155/530 (29%)
HCA4	NP_012501.1	DEADc_DDX10	52..249	CDD:350699	76/198 (38%)
		SF2_C_DEAD	266..397	CDD:350174	48/133 (36%)
		DUF4217	431..488	CDD:464056	5/56 (9%)