DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rs1 and DRS1

DIOPT Version :9

Sequence 1:	NP_001286188.1	Gene:	Rs1 / 44087	FlyBaseID:	FBgn0021995	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_013093.1	Gene:	DRS1 / 850652	SGDID:	S000003931	Length:	752	Species:	Saccharomyces cerevisiae

Alignment Length:	782	Identity:	286/782 - (36%)
Similarity:	440/782 - (56%)	Gaps:	128/782 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGATK--NLDLIGTI---EDDAEVENLSEDSDAEVEYQPTKLR-----HKKVTE----------- 44
            :|..|  |||.:.||   |||..:.:.|:|...|.: :.||.|     .|||:|
Yeast     3 VGTKKYSNLDFVPTISDSEDDVPILDSSDDEKVEAK-KTTKKRKGKNNKKKVSEGDNLDEDVHED 66

  Fly    45 FEKGFEF-------VSSVKEYN-----QDTWDDLMKYVKRKARTKTDDKIAARLQKRGGAEAVA- 96
            .:.||:|       .|:.:.:|     :...||...:||:....   |||   ::::||...:|
Yeast    67 LDAGFKFDLDADDTTSNFQGWNFLAEGESNKDDAEAFVKKDVDL---DKI---IRRKGGLVKMAH 125

  Fly    97 -----AEQSDGSEI----DLSEDELKHDNLRL---------REKKESKKKKKKAGEEDEEDEGEK 143
                 .|:::..::    |..::||..|...:         .:.:|.:::::|..||:||:|.|:
Yeast   126 IDSKQEEETEKEKVEKENDSDDEELAMDGFGMGAPMNNGDENQSEEEEEEEEKEEEEEEEEEQEE 190

  Fly   144 MQ-----------------------FADTVEANEQITSFYQ----MNLSRPLMRAIGVLGYIYPT 181
            |.                       :|...|.:|.....|:    ::||||:::.:..|||:.|:
Yeast   191 MTLEKGGKDDEIDEEDDSEEAKADFYAPETEGDEAKKQMYENFNSLSLSRPVLKGLASLGYVKPS 255

  Fly   182 PIQASTIPVALLGRDICGCAATGTGKTAAYMLPTLERLLYRPLNNKAITRVLVLVPTRELGAQVY 246
            |||::|||:||||:||...|.||:|||||:|:|.:|||||:|. ..|.|||:||:|||||..||.
Yeast   256 PIQSATIPIALLGKDIIAGAVTGSGKTAAFMIPIIERLLYKPA-KIASTRVIVLLPTRELAIQVA 319

  Fly   247 QVTKQLCQFTT-IDVGLAIGGLDVKAQEAVLRQNPDIVIATPGRLIDHIKNTPSFTLDSIEVLIL 310
            .|.||:.:|.: |..|||:|||:::.||.:|:..||||||||||.||||:|:.||.:||:|:|::
Yeast   320 DVGKQIARFVSGITFGLAVGGLNLRQQEQMLKSRPDIVIATPGRFIDHIRNSASFNVDSVEILVM 384

  Fly   311 DEADRMLDEYFAEQMKEIINSCCKTRQTMLFSATMSEQVKDLAAVSLDKPIKVFVNNNQQVAFNL 375
            |||||||:|.|.:::.||:......||.:||||||:.::|.|.::||.||:::.::..::.|..|
Yeast   385 DEADRMLEEGFQDELNEIMGLLPSNRQNLLFSATMNSKIKSLVSLSLKKPVRIMIDPPKKAATKL 449

  Fly   376 RQEFIRIREDKEGDREPILASLICR---TFHDHCMVFVQTKKQAHRLHILLGLLGVRAGELHGNL 437
            .|||:|||: ::..:..:|.:||.:   |.....:|||..|:.||||.|::||||:..|||||:|
Yeast   450 TQEFVRIRK-RDHLKPALLFNLIRKLDPTGQKRIVVFVARKETAHRLRIIMGLLGMSVGELHGSL 513

  Fly   438 TQQQRLESLKKFKEEQIDVLIATDVAARGLDIVGVKTVINFVMPITTEHYIHRVGRTARAGRAGI 502
            ||:|||:|:.|||..::.|||.||:|:|||||..::.|||:.||.:.|.|:|||||||||||.|.
Yeast   514 TQEQRLDSVNKFKNLEVPVLICTDLASRGLDIPKIEVVINYDMPKSYEIYLHRVGRTARAGREGR 578

  Fly   503 SVSLAGE--KERKIVKDIIKNAE---STIKNRIIPPEI----IEKYRNKLTSLEPEIQNILDEEQ 558
            ||:..||  ::|.||:..||:.|   |..:.:.:...:    ||:....:.|:...|::||.||:
Yeast   579 SVTFVGESSQDRSIVRAAIKSVEENKSLTQGKALGRNVDWVQIEETNKLVESMNDTIEDILVEEK 643

  Fly   559 AERQLAKTEQQLSKTERKLLG----QTNERRGWFQTKQQREAEKDRLALTTGDEDKASGGKGKGK 619
            .|:::.:.|.||.|.|..|..    |...||.|||::..::..|...||:.  ..|.:..|
Yeast   644 EEKEILRAEMQLRKGENMLKHKKEIQARPRRTWFQSESDKKNSKVLGALSR--NKKVTNSK---- 702

  Fly   620 TAGKRKRPEYGGDGEDGPPVKDLEAKRNKKKKEEPRKKTPEQLAKERAMKEIEKVSLVRAKMAKL 684
               ||||.|...||         ...|:.:|     .||.....:||..|:.:..:..:.|..|.
Yeast   703 ---KRKREEAKADG---------NGARSYRK-----TKTDRIADQERTFKKQKSTNSNKKKGFKS 750

  Fly   685 RK 686
            |:
Yeast   751 RR 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rs1	NP_001286188.1	PTZ00424	148..537	CDD:185609	193/405 (48%)
		DEADc	159..364	CDD:238167	110/209 (53%)
		Helicase_C	393..498	CDD:278689	58/107 (54%)
DRS1	NP_013093.1	SrmB	232..726	CDD:223587	227/518 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344828
Domainoid	1	1.000	193	1.000	Domainoid score	I619
eggNOG	1	0.900	-	-		E2759_KOG0338
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	413	1.000	Inparanoid score	I297
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004776
OrthoInspector	1	1.000	-	-		oto99762
orthoMCL	1	0.900	-	-		OOG6_102067
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R351
SonicParanoid	1	1.000	-	-		X2837
TreeFam	1	0.960	-	-
	13	12.780