Protein Alignment Rs1 and SPB4

DIOPT Version :10

• Sequence 1: NP_651970.1
• Gene: Rs1 / 44087
• FlyBaseID: FBgn0021995
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_116654.1
• Gene: SPB4 / 850549
• SGDID: S000001894
• Length: 606
• Species: Saccharomyces cerevisiae
• Alignment Length: 575
• Identity: 155/575 - (26%)
• Similarity: 255/575 - (44%)
• Gaps: 96/575 - (16%)

  Fly   167 PLMR-AIGVLGYIYPTPIQASTIPVALLGRDICGCAATGTGKTAAYMLPTLERLLYRPLN----N 226
            |.:| .:.|:|:...||:||||||:....:|:...:.||:|||||:::|.||:::....|    .
Yeast    16 PWIRTGLDVMGFETMTPVQASTIPMLAGNKDVVVDSVTGSGKTAAFVIPVLEKVVKEEANTSKFK 80

  Fly   227 KAITRVLVLVPTRELGAQVYQVTKQLCQFTTIDV-----GLAIGGLDVKAQEAV---LRQNPDIV 283
            ||....|::.|||||..|:..|.....:....|:     .|.:|..:...::.|   ||..|.|:
Yeast    81 KAHFHSLIIAPTRELSRQIESVVLSFLEHYPSDLFPIKCQLLVGTNEATVRDDVSNFLRNRPQIL 145

  Fly   284 IATPGRLIDHIKNTPSFTLDSIEVLILDEADRMLDEYFAEQMKEIINSCCKTRQTMLFSATMSEQ 348
            |.||||::|.:: .|:....:..::::|||||:||..|.:..::|:....|.|:|.||||||...
Yeast   146 IGTPGRVLDFLQ-MPAVKTSACSMVVMDEADRLLDMSFIKDTEKILRLLPKQRRTGLFSATMRSA 209

  Fly   349 VKDLAAVSLDKPIKVFVNNNQQVAFNLRQEFIRIREDKEGDREPILASLICRTFHDHCMVFVQTK 413
            ..|:....|..|:::.||:..|...:|:..:..:   ...::..:|.|::.......|:|:..|.
Yeast   210 GSDIFKTGLRNPVRITVNSKNQAPSSLKLNYCVV---NPAEKLQLLVSILNNYKFKKCIVYFPTC 271

  Fly   414 KQAHRLHILLGLLG--------VRAGELHGNLTQQQRLESLKKFKEE-QIDVLIATDVAARGLDI 469
            ......:..:..||        |....|||.|....|.::|..|.:. ...||..|||||||:||
Yeast   272 VSVSYFYSFIQYLGKRNILVNEVEIFSLHGKLQTSARTKTLTAFTDSLSNSVLFTTDVAARGIDI 336

  Fly   470 VGVKTVINFVMPITTEHYIHRVGRTARAGRAGISVSLAGE-KERKIVKDI-IKNA---ESTIKNR 529
            ..|..||....|..|:.::||.|||.||.|.|.:::...| :|...:..: :||.   |..::.:
Yeast   337 PDVDLVIQLDPPTNTDMFMHRCGRTGRANRVGKAITFLNEGREEDFIPFMQVKNVELEELDLEVK 401

  Fly   530 IIPPEIIEKYRNKLTSLEPEIQNILDEEQAER------QLAKTEQQLSKTERKLLGQTN-----E 583
            .|.....|.:||.:  ||       |.::.::      ...|.....|.|....|...:     :
Yeast   402 GITTNFYEDFRNWI--LE-------DRDRFDKGVKAYVAFIKYYSNHSATSIFRLQSLDYVGIAK 457

  Fly   584 RRGWFQTKQQREAEKDRLALTTGDEDKASGGKGKGKTAGKRKRPEYGGDGEDGPPVKDLEAKRNK 648
            ..|.|:..:..|..|                    ..|.:::...:.|:....|||...|.|...
Yeast   458 LYGLFRLPRMPEITK--------------------YLATEKQEGIFPGNWLVDPPVNMDEYKYKD 502

  Fly   649 KKKEEPRKKT-------------------------PEQLAKERAMKEIEKVSLVR 678
            ||:|:.|::|                         .:.|.|||.::..||:||.|
Yeast   503 KKREKERQETLKNISLINDKKKLKSELKKKNLAWSDKTLTKERKLERKEKMSLKR 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rs1	NP_651970.1	SrmB	156..576	CDD:440279	129/441 (29%)
SPB4	NP_116654.1	SrmB	8..399	CDD:440279	119/386 (31%)
		DUF4217	409..466	CDD:464056	12/65 (18%)