DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rs1 and DDX54

DIOPT Version :9

Sequence 1:	NP_001286188.1	Gene:	Rs1 / 44087	FlyBaseID:	FBgn0021995	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_001104792.1	Gene:	DDX54 / 79039	HGNCID:	20084	Length:	882	Species:	Homo sapiens

Alignment Length:	913	Identity:	238/913 - (26%)
Similarity:	372/913 - (40%)	Gaps:	275/913 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 LQKRGGAEAVAAEQSDGSEIDLSEDELK-HDNLRLRE---------------------------K 122
            |:||.|    ||.|:.||:.:..|.|:: .|:.|.|:                           :
Human    26 LRKRRG----AASQARGSDSEDGEFEIQAEDDARARKLGPGRPLPTFPTSECTSDVEPDTREMVR 86

  Fly   123 KESKKKKKKAGEEDEEDEGEKMQFADTVEANEQITSFYQMNLSRPLMRAIGVLGYIYPTPIQAST 187
            .::|||||..|                         |..|.||.|:.:.|...||..|||||..|
Human    87 AQNKKKKKSGG-------------------------FQSMGLSYPVFKGIMKKGYKVPTPIQRKT 126

  Fly   188 IPVALLGRDICGCAATGTGKTAAYMLPTLERLLYRPLNNKAITRVLVLVPTRELGAQVYQVTKQL 252
            |||.|.|:|:...|.||:||||.::||..|||........|  |.|:|.|||||..|..:.||:|
Human   127 IPVILDGKDVVAMARTGSGKTACFLLPMFERLKTHSAQTGA--RALILSPTRELALQTLKFTKEL 189

  Fly   253 CQFTTIDVGLAIGGLDVKAQEAVLRQNPDIVIATPGRLIDHIKNTPSFTLDSIEVLILDEADRML 317
            .:||.:...|.:||..::.|.|.|.:||||:|||||||: |:....|..|.|:|.::.|||||:.
Human   190 GKFTGLKTALILGGDRMEDQFAALHENPDIIIATPGRLV-HVAVEMSLKLQSVEYVVFDEADRLF 253

  Fly   318 DEYFAEQMKEIINSCCKTRQTMLFSATMSEQVKDLAAVSLDKPIKVFVNNNQQVAFNLRQEFIRI 382
            :..||||::|||.......||:|||||:.:.:.:.|...|.:|:.:.::.:.::...|:..|..:
Human   254 EMGFAEQLQEIIARLPGGHQTVLFSATLPKLLVEFARAGLTEPVLIRLDVDTKLNEQLKTSFFLV 318

  Fly   383 REDKEGDREPILASLICRTFH------DHCMVFVQTKKQAHRLHILLGLLGVRAGELHGNLTQQQ 441
            |||.:       |:::....|      |..:|||.||..|..|..||....|....::..|....
Human   319 REDTK-------AAVLLHLLHNVVRPQDQTVVFVATKHHAEYLTELLTTQRVSCAHIYSALDPTA 376

  Fly   442 RLESLKKFKEEQIDVLIATDVAARGLDIVGVKTVINFVMPITTEHYIHRVGRTARAGRAGISVSL 506
            |..:|.||...:...||.||:|||||||..:..|||:..|...:.::|||||.|||||:|.:.||
Human   377 RKINLAKFTLGKCSTLIVTDLAARGLDIPLLDNVINYSFPAKGKLFLHRVGRVARAGRSGTAYSL 441

  Fly   507 A--------------------------------------GEKERKIVKDIIKNAEST-------- 525
            .                                      |...:.:|.:.....:||
Human   442 VAPDEIPYLLDLHLFLGRSLTLARPLKEPSGVAGVDGMLGRVPQSVVDEEDSGLQSTLEASLELR 506

  Fly   526 -------------IKNRIIP-PEIIEKYRNK---LTSLEPEIQNILDEEQAER----------QL 563
                         :::|..| ||.|::.:..   ...|.|...:..:||:.:|          :.
Human   507 GLARVADNAQQQYVRSRPAPSPESIKRAKEMDLVGLGLHPLFSSRFEEEELQRLRLVDSIKNYRS 571

  Fly   564 AKTEQQLSKTERKLLGQTNERRGWFQTKQQREAEKDRLALT------TGDEDKASG--GKGKGKT 620
            ..|..:::.:.|.|..|.      .:.|:|    |||.|:.      .|.:::..|  |....:.
Human   572 RATIFEINASSRDLCSQV------MRAKRQ----KDRKAIARFQQGQQGRQEQQEGPVGPAPSRP 626

  Fly   621 AGKRKRPEYGGDGEDGPPVKDLEA-----KRN--------KKKKEEPRKK--------TPEQLAK 664
            |.:.|:||...:.|.|..|:|:.:     ||.        |:::||.|::        .|:....
Human   627 ALQEKQPEKEEEEEAGESVEDIFSEVVGRKRQRSGPNRGAKRRREEARQRDQEFYIPYRPKDFDS 691

  Fly   665 ERAMK----------------------EIEKVSLVRAKMAKLRKRPGKLGAA---------TEVH 698
            ||.:.                      |.:.::..|.::...||:...:|.:         ||..
Human   692 ERGLSISGEGGAFEQQAAGAVLDLMGDEAQNLTRGRQQLKWDRKKKRFVGQSGQEDKKKIKTESG 756

  Fly   699 R---------------------------SGASDGK-PKRRGGQSAFTNDLTDVSRGGAL------ 729
            |                           .||||.: |:||||:       .|..:.||.
Human   757 RYISSSYKRDLYQKWKQKQKIDDRDSDEEGASDRRGPERRGGK-------RDRGQAGASRPHAPG 814

  Fly   730 ----RLRSEANRHKKMTKIAAKKKASSVKLTNKAGKNKFNKGKN-----------FGGPRHAKKD 779
                |:|.|....:::.|  .:::|..:....:.|..:.: .:|           ||....:||.
Human   815 TPAGRVRPELKTKQQILK--QRRRAQKLHFLQRGGLKQLS-ARNRRRVQELQQGAFGRGARSKKG 876

  Fly   780 KKK 782
            |.:
Human   877 KMR 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rs1	NP_001286188.1	PTZ00424	148..537	CDD:185609	150/454 (33%)
		DEADc	159..364	CDD:238167	91/204 (45%)
		Helicase_C	393..498	CDD:278689	40/110 (36%)
DDX54	NP_001104792.1	PRK01297	1..469	CDD:234938	162/481 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78		14/55 (25%)
		Q motif	96..124		13/52 (25%)
		DEADc	98..300	CDD:238167	91/204 (45%)
		DEAD box	247..250		2/2 (100%)
		HELICc	315..441	CDD:238034	48/132 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	596..698		24/101 (24%)
		Interaction with nuclear receptors	605..647		10/41 (24%)
		DBP10CT	714..774	CDD:285373	8/59 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D268859at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920