Protein Alignment Rs1 and Ddx10

DIOPT Version :10

• Sequence 1: NP_651970.1
• Gene: Rs1 / 44087
• FlyBaseID: FBgn0021995
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_084212.2
• Gene: Ddx10 / 77591
• MGIID: 1924841
• Length: 875
• Species: Mus musculus
• Alignment Length: 773
• Identity: 220/773 - (28%)
• Similarity: 349/773 - (45%)
• Gaps: 124/773 - (16%)

  Fly   113 KHDNLRLREKKESKKKKKKAGEEDEEDEG--EKMQFADTVEANEQITSFYQMNLSRPLMRAIGVL 175
            ||.: |..:|||.:|:.||. |...|.||  ..||..:.:..|| ||.|....||:..::.:...
Mouse    26 KHSH-RQHQKKERRKQLKKP-EWQVEREGISRLMQNYEKINVNE-ITRFSDFPLSKKTLKGLQEA 87

  Fly   176 GYIYPTPIQASTIPVALLGRDICGCAATGTGKTAAYMLPTLERLLYRPLNNKAITRVLVLVPTRE 240
            .|...|.||..||.:||.|:|:.|.|.||:|||.|:::|.||.|......:.....||::.||||
Mouse    88 QYRLVTEIQKQTIGLALQGKDVLGAAKTGSGKTLAFLVPVLEALYRLQWTSTDGLGVLIISPTRE 152

  Fly   241 LGAQVYQVTKQLCQFTTIDVGLAIGGLDVKAQEAVLRQNPDIVIATPGRLIDHIKNTPSFTLDSI 305
            |..|.::|.:::.:......||.|||.|:| .||....|.:|::.|||||:.|:..|..|...::
Mouse   153 LAYQTFEVLRKVGKNHDFSAGLIIGGKDLK-HEAERINNINILVCTPGRLLQHMDETICFHATNL 216

  Fly   306 EVLILDEADRMLDEYFAEQMKEIINSCCKTRQTMLFSATMSEQVKDLAAVSLDKPIKVFVNNNQQ 370
            ::|:||||||:||..||:.|..||.:..|.|||:|||||.::.|||||.:||..|..|:|:...:
Mouse   217 QMLVLDEADRILDMGFADTMNAIIENLPKKRQTLLFSATQTKSVKDLARLSLKDPEYVWVHEKAK 281

  Fly   371 VA--FNLRQEFIRIREDKEGDREPILASLICRTFHDHCMVFVQTKKQAHRLHILLGLL--GVRAG 431
            .:  ..|.|.:| |.|..:  :..:|.|.:........:||..:.|:...|:.:...|  |:...
Mouse   282 YSTPATLEQNYI-ICELHQ--KISVLFSFLRSHLKKKSIVFFSSCKEVQYLYRVFCRLRPGISIL 343

  Fly   432 ELHGNLTQQQRLESLKKFKEEQIDVLIATDVAARGLDIVGVKTVINFVMPITTEHYIHRVGRTAR 496
            .|||...|.:|:|...:|..::..||.|||:||||||...|..|:.|..|.....||||.|||||
Mouse   344 ALHGRQQQMRRMEVYNEFVRKRAAVLFATDIAARGLDFPAVNWVLQFDCPEDANTYIHRAGRTAR 408

  Fly   497 AGRAGIS-VSLAGEKERKIVKDIIKNAESTIKNRIIPPEIIEKYRNKLTSLEPEIQNILDEEQAE 560
            ....|.: :.|...:|:.:|:.:::. :..:|...|.||.:...:.||.|...:.|::  :|:|:
Mouse   409 YKEDGEALLILLPSEEQGMVQQLLQK-KVPVKEIKINPEKLIDVQKKLESFLAQDQDL--KERAQ 470

  Fly   561 R---------------------QLAKTEQQLS-------------KTER----KLL--------- 578
            |                     :|..||..||             |.|:    :|:
Mouse   471 RCFVSYIRSVYLMKDKEVFNVSKLPITEYALSLGLAVAPRIRFLQKLEKQPSTELVKNPVTEAVP 535

  Fly   579 --------GQTNERRGWFQTK--------QQREAEKDRLALTTGDE--DKASGGKGKGKTAGKRK 625
                    .:.:|...:...|        ::.|..:.|||...|||  |:.:..:......||.:
Mouse   536 PRAPSLPNDEADESPAYVSEKMSVLHKSGERLEETEHRLASGDGDEEQDEETEDEETEDHLGKAR 600

  Fly   626 RP----------------------EYGGDGEDGPPVKDLEAKR------NKKKKEEPRKKTPEQL 662
            .|                      ....|.||||....|..||      :.|:.|...||.|
Mouse   601 EPHTESVVSIEEAQKVKEVSVQFLNRDDDDEDGPDADFLTVKRRDVFGLDLKENEALSKKEP--- 662

  Fly   663 AKERAMKEIEKVSLVRAKMAKLRKRPGKLGAATEVHRSGASDGKPKRRGG--QSAFTNDLTDVSR 725
            :|....|::.||    |:..|:.||..|:....    :...:|:..::..  |.....|:.:...
Mouse   663 SKSSVKKKLTKV----AEAKKVMKRSFKVNKKI----TFTDEGELVQQWPQIQKCAIKDVEEEDD 719

  Fly   726 GGALRLRSEANRHKKMTKIAAKKKASSVKLTNKAGKNKFNKGKNFGGPRHAK-KDKKK 782
            .|.:.|.....|.::..|...::....:|..::..:.|..:.:.....|.|| :|:::
Mouse   720 TGGINLDKAKERLQEEDKFDKEEYRKKIKAKHRERRLKEREARREANKRQAKARDEEE 777

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rs1	NP_651970.1	SrmB	156..576	CDD:440279	154/462 (33%)
Ddx10	NP_084212.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44		8/18 (44%)
		SrmB	68..470	CDD:440279	145/408 (36%)
		Q motif	69..97		7/27 (26%)
		DEADc_DDX10	80..277	CDD:350699	82/197 (42%)
		DEAD box	222..225		2/2 (100%)
		DUF4217	452..510	CDD:464056	12/59 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..612		14/86 (16%)
		PTZ00121	<555..777	CDD:173412	47/232 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	734..860		7/44 (16%)