DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rs1 and pit

DIOPT Version :9

Sequence 1:	NP_001286188.1	Gene:	Rs1 / 44087	FlyBaseID:	FBgn0021995	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_001287459.1	Gene:	pit / 42595	FlyBaseID:	FBgn0266581	Length:	680	Species:	Drosophila melanogaster

Alignment Length:	688	Identity:	194/688 - (28%)
Similarity:	321/688 - (46%)	Gaps:	113/688 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 EDSDAEVEYQPTKLRHKKVTE---FEKGFEFVSSVKEYNQDTWDDLMKYVKRKARTKTD-DKIAA 84
            ||.|.|.::|...|..||..:   .::..:..:|..|.:.|..:|       :|...:| |::
  Fly    60 EDDDLEEDFQEAPLPKKKQQKQPPKKQQIQVANSDSESDDDEQED-------EADEDSDLDEV-- 115

  Fly    85 RLQKRGGAEAVAAEQSDGSE-IDLSEDELKHDNLRLREKK----ESKKKKKKAGEEDEEDEGEKM 144
                   ||....:...||| .|..|||.:.:.:..::.|    :||.:..|..::||....|..
  Fly   116 -------AEVDEEDVDSGSEDDDQQEDEDEEEPVPAKKTKLLPNKSKAQNGKPAKDDEPFTVESS 173

  Fly   145 QFA-DTVEANEQITSFYQMNLSRPLMRAIGVLGYIYPTPIQASTIPVALLGRDICGCAATGTGKT 208
            ..| |..:::::..:..:..:|...:|||..:|:...|.||:.::...|.|||:.|.|.||:|||
  Fly   174 LAALDYRDSDDRSFASLKGAVSEATLRAIKEMGFTEMTEIQSKSLTPLLKGRDLVGAAQTGSGKT 238

  Fly   209 AAYMLPTLE---RLLYRPLNNKAITRVLVLVPTRELGAQVYQVTKQLCQFTTIDVGLAIGGLDVK 270
            .|:::|.:|   :|.:.|.|.   |.|:::.|||||..|.:.|.|:|........||.:||.:.:
  Fly   239 LAFLIPAVELINKLRFMPRNG---TGVIIISPTRELSMQTFGVLKELMAHHHHTYGLVMGGSNRQ 300

  Fly   271 AQEAVLRQNPDIVIATPGRLIDHIKNTPSFTLDSIEVLILDEADRMLDEYFAEQMKEIINSCCKT 335
            .:...|.:..:|::||||||:||::|:|.|...:::.||:||.||:|:..|.|::|:|||...|.
  Fly   301 VESEKLGKGINILVATPGRLLDHLQNSPDFLYKNLQCLIIDEVDRILEIGFEEELKQIINLLPKR 365

  Fly   336 RQTMLFSATMSEQVKDLAAVSL-DKPIKVFVNNNQQVAF--NLRQEFIRIREDKEGDREPILASL 397
            |||||||||.:.:::.|:.::| .:||.|.|::||..|.  .|.|.:|....:|   |..:|.:.
  Fly   366 RQTMLFSATQTARIEALSKLALKSEPIYVGVHDNQDTATVDGLEQGYIVCPSEK---RLLVLFTF 427

  Fly   398 ICRTFHDHCMVFVQTKKQAHRLHILLGLLGVRAGELHGNLTQQQRLESLKKFKEEQIDVLIATDV 462
            :.:......|||..:.......|.|...:.:....:||...|.:|..:..:|...:..:|:.|||
  Fly   428 LKKNRKKKVMVFFSSCMSVKYHHELFNYIDLPVTSIHGKQKQTKRTTTFFQFCNAESGILLCTDV 492

  Fly   463 AARGLDIVGVKTVINFVMPITTEHYIHRVGRTAR-AGRAGISVSLAGEKERKIVKDIIKNAESTI 526
            |||||||..|..::.:..|.....|||||||||| :|.:|.::.|...:|...:: .:|.|:
  Fly   493 AARGLDIPQVDWIVQYDPPDDPREYIHRVGRTARGSGTSGHALLLMRPEELGFLR-YLKAAK--- 553

  Fly   527 KNRIIPPEIIEKYRNKLTSLEPEIQNILD-EEQAERQLAKTEQQLSKTERKLLGQTNERRGWFQT 590
                :|          |...|...|.|.| :.|.|:.:||                    .:|..
  Fly   554 ----VP----------LNEFEFSWQKIADIQLQLEKLIAK--------------------NYFLN 584

  Fly   591 KQQREAEKD----------RLALTTGDEDKASGGKGKGKTAGKRKRPEYGGDGEDGPPVKDLEAK 645
            :..:||.|.          :........|..:..|..|...               |||.||:..
  Fly   585 QSAKEAFKSYVRAYDSHQLKQIFNVNTLDLQAVAKSFGFLV---------------PPVVDLKVG 634

  Fly   646 RNKKKKEEPR---------KKTPE-QLAKERAMKEIEK 673
            ..|:::.|.|         ||..| ..:|:|..|::.:
  Fly   635 AAKRERPEKRVGGGGFGFYKKMNEGSASKQRHFKQVNR 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rs1	NP_001286188.1	PTZ00424	148..537	CDD:185609	132/395 (33%)
		DEADc	159..364	CDD:238167	80/208 (38%)
		Helicase_C	393..498	CDD:278689	34/105 (32%)
pit	NP_001287459.1	SrmB	186..677	CDD:223587	161/546 (29%)
		DEADc	187..394	CDD:238167	80/209 (38%)
		HELICc	408..537	CDD:238034	41/131 (31%)
		DUF4217	569..627	CDD:290667	11/92 (12%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451710
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940