DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rs1 and CG5589

DIOPT Version :9

Sequence 1:	NP_001286188.1	Gene:	Rs1 / 44087	FlyBaseID:	FBgn0021995	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_649009.1	Gene:	CG5589 / 39979	FlyBaseID:	FBgn0036754	Length:	594	Species:	Drosophila melanogaster

Alignment Length:	605	Identity:	171/605 - (28%)
Similarity:	272/605 - (44%)	Gaps:	96/605 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 EAVAAEQSDGSEIDLSEDELKHDNLRLREKKESKKKKK----------KAGEEDEEDE------- 140
            |.|.:|:||..:.|::|..|...:...:.|::..||:|          ||.||..|..
  Fly    41 EPVKSEESDKDDEDITEFRLLDGDSSNQPKRKKPKKEKTLSPKELEIQKAAEEANETRKQYGIRV 105

  Fly   141 -GEKM-----QFADTVEANEQITSFYQMNLSRPLMRAIGVLGYIYPTPIQASTIPVALLGRDICG 199
             |:.:     .|.......:.:....|..|||         .:.:|||||...:||.|..|.:..
  Fly   106 LGKNVPPPVDSFGTLTRDFKMLPRLQQNLLSR---------NFDHPTPIQMQALPVLLQRRALMA 161

  Fly   200 CAATGTGKTAAYMLPTLERLLYRPLNNKAITRVLVLVPTRELGAQVYQVTKQLCQFTTIDVGLAI 264
            ||.||:|||.|::.|.:..|.......   .|.|||.|||||..|:|:...:|.:.|.:......
  Fly   162 CAPTGSGKTLAFLTPIINGLRAHKTTG---LRALVLAPTRELAQQIYRECAELTRETGLRTHFIS 223

  Fly   265 GGLDVKAQE-AVLRQNPDIVIATPGRLIDHIKNTPS-FTLDSIEVLILDEADRMLDE---YFAEQ 324
            ...:.|.:. |..:|..||:::||.|:...::..|. ..|..:|..:||||||:::|   .|.||
  Fly   224 KVSEAKQKHGAECKQRYDILVSTPNRVRFLLQQEPPLLDLSHVEWFVLDEADRLMEEGQNNFKEQ 288

  Fly   325 MKEIINSCCK-TRQTMLFSATMSEQVKDLAAVSLDKPIKVFVNNNQQVAFNLRQEFIRIREDKEG 388
            :.:|..:|.. |:....||||.:..|...|...|...:::.:.........::||.:.:  ..||
  Fly   289 LDDIYAACSNPTKCVAFFSATYTVPVAKWALRHLKNLVRITIGVQNSATETVQQELLFV--GSEG 351

  Fly   389 DREPILASLICRTFHDHCMVFVQTKKQAHRLHILLGLLGVRAGELHGNLTQQQRLESLKKFKEEQ 453
            .:...:..|:.:......:||||:|::|.:|...|...|:....:|...:|.||...:|.|:|..
  Fly   352 GKLVAIRDLVRQGLQPPVLVFVQSKERAKQLFEELLYDGINVDVIHAERSQHQRDNCVKAFREGS 416

  Fly   454 IDVLIATDVAARGLDIVGVKTVINFVMPITTEHYIHRVGRTARAGRAGISVSLAGEKERKIVKD- 517
            |.|||.|::..||:|..||..|||:..|.||..||||:|||.||||.|.:::...:::...::.
  Fly   417 IWVLICTELMGRGIDFKGVNLVINYDFPPTTISYIHRIGRTGRAGRPGRAITFFTQEDTSNLRGI 481

  Fly   518 --IIKNAESTIKNRIIPPEIIEKYRNKL------------TSLEPEIQNILDEEQAERQLAKTEQ 568
              ||||:..|:...::..:.:.|...|:            |.:.||.:.  ||:....:|.|.|
  Fly   482 ALIIKNSGGTVPEYMLQMKKVRKSEAKMRAKKPLDREDISTKIRPETKG--DEKHKSTKLKKVE- 543

  Fly   569 QLSKTERKLLGQTNERRGWFQTKQQREAEKDRLALTTGDEDKASGGKGKGKTAGKRKRPEYGGDG 633
               :||:.|    ..|:|:         |||    ....:.|....|.:.|.|||||     |:.
  Fly   544 ---RTEKIL----KNRKGY---------EKD----LNSKQKKLGNIKTELKPAGKRK-----GNV 583

  Fly   634 EDGPPVKDLEAKRNKKKKEE 653
            |          |:.|.|..:
  Fly   584 E----------KKTKNKNNQ 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rs1	NP_001286188.1	PTZ00424	148..537	CDD:185609	121/397 (30%)
		DEADc	159..364	CDD:238167	67/210 (32%)
		Helicase_C	393..498	CDD:278689	41/104 (39%)
CG5589	NP_649009.1	SrmB	87..594	CDD:223587	159/559 (28%)
		P-loop_NTPase	123..329	CDD:304359	67/217 (31%)
		HELICc	349..469	CDD:238034	47/119 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451701
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940