DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rs1 and Gem3

DIOPT Version :9

Sequence 1:	NP_001286188.1	Gene:	Rs1 / 44087	FlyBaseID:	FBgn0021995	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_001261678.1	Gene:	Gem3 / 39195	FlyBaseID:	FBgn0011802	Length:	1028	Species:	Drosophila melanogaster

Alignment Length:	691	Identity:	165/691 - (23%)
Similarity:	292/691 - (42%)	Gaps:	112/691 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 GEEDEEDEGEKMQFADTVEANEQITSFYQMNLSRPLMRAIGVLGYIYPTPIQASTIPVALLGRDI 197
            |||...|           .|..|:.:|.::.|.|.|:..:....::.||.|||:.||:||...|:
  Fly    12 GEERSSD-----------VAPGQVKTFEELRLYRNLLNGLKRNNFVTPTKIQAAAIPMALAKMDL 65

  Fly   198 CGCAATGTGKTAAYMLPTLERLLYRPLNNKAITRVLVLVPTRELGAQVYQVTKQLCQ-FTTIDVG 261
            ...:.:|||||..|::..::.  :.|..|:  ...:::||||||..||......||: |......
  Fly    66 IIQSKSGTGKTLIYVIAVVQS--FNPNINQ--PHAMIVVPTRELAIQVQDTFFHLCKSFRDFKCS 126

  Fly   262 LAIGGLDVKAQEAVLRQNPDIVIATPGRLIDHIKNTPSFTLDSIEVLILDEADRMLD-EYFAEQM 325
            ..|||.|| |::........::|.|||||: |:.....|.:..:.:|:|||||::.. :.....:
  Fly   127 AFIGGTDV-AKDRKRMNESRVIIGTPGRLL-HLYENRVFDVSKLRLLVLDEADQLYQTKSLQHTV 189

  Fly   326 KEIINSCCKTRQTMLFSATMSEQVKDLAAVSLDKPIKVFVNNNQQVAFNLRQEFIRIREDKEGDR 390
            .::|.:..|.||.:..|||..:.:.:..|..:|||:.:..:....|...:||....:.:......
  Fly   190 SKLIEAMPKNRQIIACSATYDQNLDERLAKVMDKPMLISNSERATVLLGIRQFVYELPQQNNSVE 254

  Fly   391 E-----PILASLICRTFHDHCMVFVQTKKQAHRLHILLGLLGVRAGELHGNLTQQQRLESLKKFK 450
            |     .||..:..:..::..::|..::.:|......|...|:....:.|.:.|.:||...:.::
  Fly   255 EMRLKLQILGQIFNQLPYEQAIIFASSQMRADSYKNYLTASGIDCHLISGAMEQSERLHVFEGYR 319

  Fly   451 EEQIDVLIATDVAARGLDIVGVKTVINFVMPITTEHYIHRVGRTARAGRAGISVS-LAGEKERKI 514
            ...:.:|:|||:.|||:|......|||...|.....|:||:||..|.|..||::: :|.:||.:.
  Fly   320 NFTMRILVATDLMARGVDSPHANLVINIDPPQDHVTYLHRIGRAGRFGSKGIAITFIASKKESQR 384

  Fly   515 VKDI---IKNAESTIK--NRIIPPEI----IEKY--------RNKLTSLEPEIQNILDEEQAERQ 562
            .:::   |..|.|.::  ...:|.|.    .|||        .|.|..:...|:    |.:::..
  Fly   385 FREMSKKIATAWSVLEFPKEPMPNEFNFWDFEKYNFDYYIKEENPLQEMPMPIK----ENRSKEN 445

  Fly   563 LAKTEQQLSKTERKLLGQTNERR-------GWFQTKQQREAEKDRLALTTGD------EDKASGG 614
            :..:...|...::   .|..:||       .....:.|:|.|.:.|..::.:      ::|....
  Fly   446 VDASSVDLENLQK---DQDGKRRDPDKLPVALENVETQKELELENLPESSHNNKNLRVKEKEIVR 507

  Fly   615 KGKGKTAGKRKRPEYGGDGEDGPPVKDLEAKRNKKKKEEPRKK--TPEQLAKERAMKEIEKVSLV 677
            :||.|....:.    ||               :|..|.|.|||  ||.:|.|:  :.|:::...:
  Fly   508 QGKLKETNSKA----GG---------------SKTNKTERRKKSNTPSKLQKQ--ITEVQQTPEI 551

  Fly   678 RAKMAKLRKRPGKLGAATEVHR-SGASDGKPKRRGGQS-------AFTNDLTDVSRGGALRLRSE 734
            ......:::...:.....|.|. :||.:.:...:..|.       ..|..||      .|.|..|
  Fly   552 TVNKYYMQEDIQRTADGKEYHPVNGAGNHQVPSKSNQKPVEFISPELTPTLT------PLELTQE 610

  Fly   735 ------------ANR-HKKMTKIAAKKKASSVKLTNKAGKN 762
                        ||. :.|...:||..:.||:.:.|....|
  Fly   611 PSPTTVTPPAPPANSINNKTYCLAAPTQTSSMTIQNMVISN 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rs1	NP_001286188.1	PTZ00424	148..537	CDD:185609	109/405 (27%)
		DEADc	159..364	CDD:238167	64/206 (31%)
		Helicase_C	393..498	CDD:278689	28/104 (27%)
Gem3	NP_001261678.1	SrmB	24..541	CDD:223587	137/548 (25%)
		P-loop_NTPase	27..228	CDD:304359	64/206 (31%)
		Helicase_C	259..367	CDD:278689	28/107 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451699
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840