DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rs1 and mus301

DIOPT Version :9

Sequence 1:	NP_001286188.1	Gene:	Rs1 / 44087	FlyBaseID:	FBgn0021995	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_648178.1	Gene:	mus301 / 38905	FlyBaseID:	FBgn0002899	Length:	1051	Species:	Drosophila melanogaster

Alignment Length:	762	Identity:	147/762 - (19%)
Similarity:	270/762 - (35%)	Gaps:	237/762 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NLSEDSDAEVEYQPTKLRHKKVTEFE---KGFEFVSSVKEYNQDTWDDLMKYVKRKARTKTDDKI 82
            :|:::.:|:..::...|....:.|.|   .|.:..|.....|...:.|.|.:.|    .||.:|:
  Fly   117 DLADEENADKLFKKINLNDLSIAEMEDIFHGADDFSDPMVQNTQLFLDAMTFKK----PKTPEKL 177

  Fly    83 AARLQKRGG---AEAVAAEQSDGSEIDLSEDELKHDNLRLREKKESKKKKKKAGEEDEEDEGEKM 144
            .|.|:....   :::|......|::. ::.:|||:.:|.                  :....|..
  Fly   178 LAPLKDDSMSFISKSVIEGLVQGTQY-VTCEELKNQSLL------------------DPVNWETQ 223

  Fly   145 QFADTVEANEQIT------SFYQM--NLSRPLMRAIGVLGYIYPTPIQASTIPVALLGRDICGCA 201
            .|||..:.|:.|.      .||.:  .:.:.::...|: ..:|....:...:|.....:::....
  Fly   224 AFADFEKNNQDIDKFPSKGEFYGLPDKVKKMILEHKGI-NSLYEWQDECLNLPAIRQRKNLIYAL 287

  Fly   202 ATGTGKTAAYMLPTLERLLYRPLNNKAITRVLVLVPTRELGAQVYQVTKQLCQFTTIDVGLAIGG 266
            .|..|||....:..|..||.|..|      ||.::|...:   |.:....:..| .||:...:..
  Fly   288 PTSGGKTLVAEILMLRELLCRERN------VLFILPYVSI---VQEKVSAMSPF-AIDLDFIVEE 342

  Fly   267 LDV---KAQEAVLRQNPDIVIATPGR---LIDHIKNTPSFTLD-----SIEVLILDEADRM---- 316
            ...   |......|:...:.||:..:   |:|.:       :|     .|.::::||...:
  Fly   343 YTAGKGKCPPQPRRKRRSLFIASIEKGAVLMDSL-------IDVQRPHEIGLVVVDELHLIGEKG 400

  Fly   317 ----LDEYFAEQMKEIINSCCKTRQTMLFSAT---MSE---------QVKDLAAVSLDKPIK--- 362
                |:.:..:.|  .:|:   ..|.:..|||   :||         ..:....|.|.:.||
  Fly   401 RGATLEAFLTKVM--FLNA---NIQIVGMSATIGNLSEISSFLNADVYTRGFRPVELKEYIKCGP 460

  Fly   363 --VFVNNNQQVAFNLRQEFIRIREDKEGDREPI-------LASLICRTFHDH-CMVFVQTKKQAH 417
              :.:|:..|   .|.:.|:..|..:....|.:       ||.||.....:| |:||..::|...
  Fly   461 DLLEINSAGQ---TLEEIFVPSRSVEYNYSEAVKRADPDHLAGLISECAPEHCCLVFCPSRKNCE 522

  Fly   418 RLHILL----------------------------GLLG-VRAGEL-------HGNLTQQQR--LE 444
            .:.:||                            |:|. |.|..|       |..||..:|  :|
  Fly   523 NVALLLSRIVPKHKFFEHRRSEKLDLMDALDKMCGILSPVLAKTLPYGIAYHHSGLTTDERKYIE 587

  Fly   445 SLKKFKEEQIDVLIATDVAARGLDIVGVKTVINFVMP------ITTEHYIHRVGRTARA--GRAG 501
            :..:|  ..:.|:..|...|.|:::...:.:|.  .|      :|...|...|||..||  |.||
  Fly   588 TAYRF--GVVTVICCTSTLAAGVNLPAKRVIIR--APYVGQEFLTLCKYKQMVGRAGRAGLGEAG 648

  Fly   502 ISVSLAGEKERKIV---------------------------------------KDIIKNAESTI- 526
            .|:.:|..|:..:|                                       :|:.:...||:
  Fly   649 ESILIAQSKDNLLVGQMLFSPMDKALSSLDQNEAVGLQSLILSVVGLNLAECRRDLNRLVNSTLL 713

  Fly   527 ----------KNRIIPPEIIEKYRNKLTSL-EPEIQNILDEEQAERQLAKTEQQLSKTERK---- 576
                      .|.|:...:.|.::||:..| ||:.::.::...     ..|.|.:|:..|.
  Fly   714 SVQAKSLEVAVNEIVLRILREMFKNKVLQLAEPQAKSKINSSD-----IITSQDVSQANRPAGDR 773

  Fly   577 --LLGQ------TNERRGWFQT-----------KQQREAEKDRLALT 604
              |:||      ||..|..|:.           |:.::|:: :|.||
  Fly   774 RLLIGQSTPFKLTNIGRAAFKAGIDYKRANAIHKELKQAQQ-QLILT 819

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rs1	NP_001286188.1	PTZ00424	148..537	CDD:185609	100/536 (19%)
		DEADc	159..364	CDD:238167	44/242 (18%)
		Helicase_C	393..498	CDD:278689	35/158 (22%)
mus301	NP_648178.1	BRR2	247..998	CDD:224125	117/609 (19%)
mus301	NP_648178.1	DEXHc_POLQ-like	247..449	CDD:350784	38/224 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100