DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rs1 and Ddx54

DIOPT Version :9

Sequence 1:	NP_001286188.1	Gene:	Rs1 / 44087	FlyBaseID:	FBgn0021995	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_001178477.1	Gene:	Ddx54 / 360815	RGDID:	1562539	Length:	874	Species:	Rattus norvegicus

Alignment Length:	790	Identity:	221/790 - (27%)
Similarity:	335/790 - (42%)	Gaps:	168/790 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 RLQKR--GGAEAVAAEQSDGS-EIDLSED------------------ELKHD---NLRLREKKES 125
            ||:||  |.::|..::..||. ||...:|                  |...|   :.|...:.::
  Rat    24 RLRKRRTGASQARDSDSEDGEFEIQAEDDARARKLGPGRALPSFPTSECVSDVEPDTREMVRAQN 88

  Fly   126 KKKKKKAGEEDEEDEGEKMQFADTVEANEQITSFYQMNLSRPLMRAIGVLGYIYPTPIQASTIPV 190
            |||||..|                         |..|.||.|:.:.|...||..|||||..||||
  Rat    89 KKKKKSGG-------------------------FQSMGLSYPVFKGIMKKGYKVPTPIQRKTIPV 128

  Fly   191 ALLGRDICGCAATGTGKTAAYMLPTLERLLYRPLNNKAITRVLVLVPTRELGAQVYQVTKQLCQF 255
            .|.|:|:...|.||:||||.::||..|||..|.....|  |.|:|.|||||..|..:.||:|.:|
  Rat   129 ILDGKDVVAMARTGSGKTACFLLPMFERLKARSAQTGA--RALILSPTRELALQTMKFTKELGKF 191

  Fly   256 TTIDVGLAIGGLDVKAQEAVLRQNPDIVIATPGRLIDHIKNTPSFTLDSIEVLILDEADRMLDEY 320
            |.:...|.:||..::.|.|.|.:||||:|||||||: |:....:..|.|:|.::.|||||:.:..
  Rat   192 TGLKTALILGGDKMEDQFAALHENPDIIIATPGRLV-HVAVEMNLKLQSVEYVVFDEADRLFEMG 255

  Fly   321 FAEQMKEIINSCCKTRQTMLFSATMSEQVKDLAAVSLDKPIKVFVNNNQQVAFNLRQEFIRIRED 385
            ||||::|||.......||:|||||:.:.:.:.|...|.:|:.:.::.:.::...|:..|..:|||
  Rat   256 FAEQLQEIIGRLPGGHQTVLFSATLPKLLVEFARAGLTEPVLIRLDVDSKLNEQLKTSFFLVRED 320

  Fly   386 KEGDREPILASLICRTF--HDHCMVFVQTKKQAHRLHILLGLLGVRAGELHGNLTQQQRLESLKK 448
               .:..:|..|:....  .|..:|||.||..|..|..||...||....::..|.|..|..:|.|
  Rat   321 ---TKTAVLLYLLQNVVRPQDQNVVFVATKHHAEYLTELLTGQGVSCAHIYSALDQTARKINLAK 382

  Fly   449 FKEEQIDVLIATDVAARGLDIVGVKTVINFVMPITTEHYIHRVGRTARAGRAGISVSLAGEKERK 513
            |...:...||.||:|||||||..:..|||:..|...:.::|||||.|||||:|.:.||....|..
  Rat   383 FTHNKCSTLIVTDLAARGLDIPLLDNVINYSFPAKGKLFLHRVGRVARAGRSGTAYSLVAPDEVP 447

  Fly   514 IVKD----------IIKNAESTIKNRI--------IPPEIIEKYRNKLTSLEPEIQNILDEEQAE 560
            .:.|          :.:..|......:        :|..:::   ::.:||:..:|..|:.:..:
  Rat   448 YLLDLHLFLGRSVTLARPHEEPSSGAVGRDGVLGRVPQSVVD---DEDSSLQTALQASLELQGLQ 509

  Fly   561 RQLAKTEQQLSKTERKLLGQTNERRGWFQTKQQ----------REAEKDRLALTTGDEDKASGGK 615
            |.....:||..::......::.:|.......:.          .|.|..||.|.  |..|
  Rat   510 RVANNAQQQYLRSRPAPSPESIKRAKELDLAELGLHPLFSSCFEEGELQRLRLV--DSIK----- 567

  Fly   616 GKGKTAGKRKRP---EYGGDGEDGPPVKDLEAKRNKKKK--------EEPRKKTPEQLAKERAMK 669
                  ..|.|.   |.....:| |..:.:.|||.:.:|        .:.|:..|.....:|.:.
  Rat   568 ------NYRTRTTIFEINASSKD-PSSQMMRAKRQRDRKAITSFHQGRQERQDGPADPVPQRELP 625

  Fly   670 EIEKVSLVRAKMAKLRKRPGKLGAATEV-----HRSGASDGKPKRR------------------- 710
            :.|:..:|....          |..|||     .|.|.:.|..:||
  Rat   626 QKEEEDMVETVE----------GVFTEVVGQKQPRPGPNQGAKRRRKEASQRDQEFYVPYRPKDF 680

  Fly   711 ---------GGQSAFTNDLTDVSRGGALRLRSE----ANRHKKMTKIAAKKKASSVKLTNKAGKN 762
                     |...||...:.    |..|.|..:    .:|.::..|...|||    :...::|:.
  Rat   681 DSERGLSVSGAGGAFEQQVA----GAVLDLMGDEAQNMSRGRQQLKWDRKKK----RFVGQSGQE 737

  Fly   763 KFNKGKNFGG 772
            ...|.|...|
  Rat   738 DKKKIKTESG 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rs1	NP_001286188.1	PTZ00424	148..537	CDD:185609	148/408 (36%)
		DEADc	159..364	CDD:238167	91/204 (45%)
		Helicase_C	393..498	CDD:278689	42/106 (40%)
Ddx54	NP_001178477.1	SrmB	69..536	CDD:223587	165/500 (33%)
		DEADc	97..299	CDD:238167	91/204 (45%)
		HELICc	314..440	CDD:238034	50/128 (39%)
		DBP10CT	705..765	CDD:285373	10/47 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D268859at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920