DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rs1 and ddx54

DIOPT Version :9

Sequence 1:	NP_001286188.1	Gene:	Rs1 / 44087	FlyBaseID:	FBgn0021995	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_775375.1	Gene:	ddx54 / 286777	ZFINID:	ZDB-GENE-021220-2	Length:	862	Species:	Danio rerio

Alignment Length:	893	Identity:	236/893 - (26%)
Similarity:	369/893 - (41%)	Gaps:	222/893 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 KLRHKKVTEFEKGFEFVSSVKEYNQDTWDDLMKYVKRKARTKTDDKIAARLQKR--GGAEAVAAE 98
            ||..:|.:...:..|..|..:|:            :..|..|.|:....|...|  ..:|.|
Zfish     7 KLMRRKKSGANRDHELQSDDEEF------------EVAAGVKDDENTTVRRLPRFPASSECV--- 56

  Fly    99 QSDGSEIDLSEDELKHDNLRLREKKESKKKKKKAGEEDEEDEGEKMQFADTVEANEQITSFYQMN 163
                |:::|...||        .:.::|||||..|                         |..|.
Zfish    57 ----SDVELDTREL--------VRAQNKKKKKSGG-------------------------FQSMG 84

  Fly   164 LSRPLMRAIGVLGYIYPTPIQASTIPVALLGRDICGCAATGTGKTAAYMLPTLERLLYRPLNNKA 228
            ||.|:.:.|...||..|||||..||||.|.|:|:...|.||:|||||:::|..|:|........|
Zfish    85 LSYPVYKGIMKKGYKVPTPIQRKTIPVILDGKDVVAMARTGSGKTAAFLVPLFEKLKAPQAQTGA 149

  Fly   229 ITRVLVLVPTRELGAQVYQVTKQLCQFTTIDVGLAIGGLDVKAQEAVLRQNPDIVIATPGRLIDH 293
              |.|:|.|||||..|..:.||:|.:||.:...|.:||..:..|.|.|.:||||:|.|||||: |
Zfish   150 --RALILTPTRELALQTMKFTKELGKFTGLRTALILGGDSMDDQFAALHENPDIIIGTPGRLM-H 211

  Fly   294 IKNTPSFTLDSIEVLILDEADRMLDEYFAEQMKEIINSCCKTRQTMLFSATMSEQVKDLAAVSLD 358
            :....:..|.|:|.::.|||||:.:..||||::|||......|||:|||||:.:.:.:.|...|.
Zfish   212 VIQEMNLKLQSVEYVVFDEADRLFEMGFAEQLQEIIRRLPDARQTLLFSATLPKLIVEFARAGLT 276

  Fly   359 KPIKVFVNNNQQVAFNLRQEFIRIREDKEGDREPILASLICRTF--HDHCMVFVQTKKQAHRLHI 421
            :|:.:.::.:.:::..|:..|..:|.|   |:..:|..|:....  .:..:|||.||.....|..
Zfish   277 EPVLIRLDVDTKLSEQLKLSFFSLRLD---DKPALLLHLLRNVVKPQEQTVVFVATKHHVEYLKE 338

  Fly   422 LLGLLGVRAGELHGNLTQQQRLESLKKFKEEQIDVLIATDVAARGLDIVGVKTVINFVMPITTEH 486
            ||...||....::..|.|..|..|:.:|...::.:|:.|||||||:||..:..|||:..|...:.
Zfish   339 LLSAEGVDCSCIYSALDQTARKISIGRFVHRKVMLLLVTDVAARGIDIPLLDNVINYNFPCKPKL 403

  Fly   487 YIHRVGRTARAGRAGISVSLA----------------------------------GEKERKIVKD 517
            ::|||||.|||||.|.:.||.                                  |...:.::.|
Zfish   404 FLHRVGRVARAGRGGTAYSLVCPDEVPYLYDLHLFLGRPMQLAHPEHTQEADGVFGRVPQSVLDD 468

  Fly   518 --------------------IIKNA-ESTIKNRIIP-PEIIEKYRN-KLT--SLEPEIQNILDEE 557
                                :.:|| :..:|:|.:| .|.|::.|| :||  ::.|.:...|::.
Zfish   469 EECQLITAHQNSLDLQNLRRVSENAYKQYLKSRPVPSAESIKRSRNTQLTDMAVHPLLGCGLEKM 533

  Fly   558 QAERQL------------------AKTEQQLSKTERKLLGQTNERRGWF---------------- 588
            :.:|.|                  :..:...|:..|....:..:|...|
Zfish   534 ELDRLLMVDTIKGYKAKSTIFEINSSNKTSASEVMRAKRSRDRQRVEKFSRARAELRAEPGAGLR 598

  Fly   589 -------QTKQQREAEKDRLALTTGDEDKASGGK-------------GKGKTAGKRK------RP 627
                   :|:::.|.|::.|:....:   ..|||             .|.:|||:.:      ||
Zfish   599 AEPPVHRETQEEDEEEQEELSTVFSE---VVGGKRRRPDAEPHTHKSKKSRTAGRDQEFYIPYRP 660

  Fly   628 -----EYG-------GDGED----------GPPVKDLEAKRNKKKKEEPRKKTPEQLAKERAMKE 670
                 |.|       |..|.          |.....|...::..|.:..:|:......||...|:
Zfish   661 KDFNSERGLSLDSGAGSFEQQASSAVLDLIGDESNTLNQHKSLMKWDRKKKRFVRDTGKEDKHKK 725

  Fly   671 I--EKVSLVRAKMAK------LRKRPGKLGAATE-------VHRSGASDGKPKRRGGQSAFTNDL 720
            |  |...|:|....|      .:|:....|.|::       ..|...|.|:..|..|:||..:..
Zfish   726 IRTESGQLIRGHKKKKSFYEEWKKKYKVEGGASDSDGEGGGAQRGRGSAGRRGRGRGRSAAGSQA 790

  Fly   721 TDVSRGGALRLRSEANRHKKMTKIAAKKKASSVKLTNKAGKNKFNKGK 768
            |.....|...:|||....:::.| ..|:||....|.:...|...||||
Zfish   791 TPAQHQGGSGVRSELKNRQQILK-QRKRKAKQQFLQSGGMKKLRNKGK 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rs1	NP_001286188.1	PTZ00424	148..537	CDD:185609	146/446 (33%)
		DEADc	159..364	CDD:238167	89/204 (44%)
		Helicase_C	393..498	CDD:278689	38/106 (36%)
ddx54	NP_775375.1	DEADc	80..282	CDD:238167	89/204 (44%)
		DEXDc	95..282	CDD:214692	83/189 (44%)
		HELICc	303..423	CDD:238034	44/122 (36%)
		DBP10CT	688..750	CDD:285373	12/61 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D268859at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920