DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rs1 and Ddx27

DIOPT Version :9

Sequence 1:	NP_001286188.1	Gene:	Rs1 / 44087	FlyBaseID:	FBgn0021995	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_694705.2	Gene:	Ddx27 / 228889	MGIID:	2385884	Length:	760	Species:	Mus musculus

Alignment Length:	812	Identity:	373/812 - (45%)
Similarity:	501/812 - (61%)	Gaps:	106/812 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LDLIGTI--EDDAEVENLSEDSDAEVE------YQPTKLRHKKVTEFEKGFEFVSSVKEYNQDTW 63
            |..|.||  .|:..||..|:..|.|.|      .:...|:..:..:|...|.|......|: .:|
Mouse     5 LGFIRTIGENDEVPVEPESDSGDEEEEGPIVLGRKQKALQKNRSADFNPDFVFTEKEGMYD-GSW 68

  Fly    64 --DDLMKYVKRK-ARTKTDDKIAARLQKRGGAEAVAA-----EQSDG------------------ 102
              .|:|..:|:| |.|..|:|| .:::||..||...|     |:.:|
Mouse    69 ALADVMSQLKKKRAATTLDEKI-EKVRKRRKAEDKEAKSGKVEEKEGQADSDLKGQENPGEDEAG 132

  Fly   103 -----SEIDL-SEDE---LKHDNLRLREKKESKKKKKKAGEEDEEDEGEKMQFADTVEANEQITS 158
                 ||.|. ||||   .|.|.|:::|||:.||.:...|..::..|.:|.            .|
Mouse   133 SKDEDSETDYSSEDEEILTKADTLKVKEKKKKKKGQAAGGFFEDASEYDKS------------LS 185

  Fly   159 FYQMNLSRPLMRAIGVLGYIYPTPIQASTIPVALLGRDICGCAATGTGKTAAYMLPTLERLLYRP 223
            |..|||||||::||..:|:..|||||.:.|||.|||:|||.|||||||||||:.||.||||:|:|
Mouse   186 FQDMNLSRPLLKAITAMGFKQPTPIQKACIPVGLLGKDICACAATGTGKTAAFALPVLERLIYKP 250

  Fly   224 LNNKAITRVLVLVPTRELGAQVYQVTKQLCQFTTIDVGLAIGGLDVKAQEAVLRQNPDIVIATPG 288
             ...|:|||||||||||||.||:.|||||.||.:|...||:||||||:|||.||..|||:|||||
Mouse   251 -RQAAVTRVLVLVPTRELGIQVHSVTKQLAQFCSITTCLAVGGLDVKSQEAALRAAPDILIATPG 314

  Fly   289 RLIDHIKNTPSFTLDSIEVLILDEADRMLDEYFAEQMKEIINSCCKTRQTMLFSATMSEQVKDLA 353
            |||||:.|.|||.|.||||||||||||||||||.|||||||..|...||||||||||:::|||||
Mouse   315 RLIDHLHNCPSFHLSSIEVLILDEADRMLDEYFEEQMKEIIRMCSHHRQTMLFSATMTDEVKDLA 379

  Fly   354 AVSLDKPIKVFVNNNQQVAFNLRQEFIRIREDKEGDREPILASLICRTFHDHCMVFVQTKKQAHR 418
            :|||..|:::|||:|..||..|||||||||.::|||||.|:|:|:.|||.||.|:|.||||||||
Mouse   380 SVSLKNPVRIFVNSNTDVAPFLRQEFIRIRPNREGDREAIVAALLMRTFTDHVMLFTQTKKQAHR 444

  Fly   419 LHILLGLLGVRAGELHGNLTQQQRLESLKKFKEEQIDVLIATDVAARGLDIVGVKTVINFVMPIT 483
            :||||||||::.|||||||:|.||||:|::||:||||:|:|||||||||||.||||||||.||.|
Mouse   445 MHILLGLLGLQVGELHGNLSQTQRLEALRRFKDEQIDILVATDVAARGLDIEGVKTVINFTMPNT 509

  Fly   484 TEHYIHRVGRTARAGRAGISVSLAGEKERKIVKDIIKNAESTIKNRIIPPEIIEKYRNKLTSLEP 548
            .:||:|||||||||||||.||||.||:|||::|:|:|.|::.:|.||:|.::|.|:|:|:..||.
Mouse   510 VKHYVHRVGRTARAGRAGRSVSLVGEEERKMLKEIVKAAKAPVKARILPQDVILKFRDKIEKLEK 574

  Fly   549 EIQNILDEEQAERQLAKTEQQLSKTERKLLGQTNE------RRGWFQTKQQREAEKDRLALTTGD 607
            ::..:|..|..|:::.::|.|:. |.::||.:..|      .|.|||||::|:.||...||...|
Mouse   575 DVYAVLQLEAEEKEMQQSEAQID-TAQRLLAKGKETADQEPERSWFQTKEERKKEKIAKALQEFD 638

  Fly   608 EDKASGGKGKGKTAGKRKRPEYGGDGEDGPPVKDLEAKRNKKKKEEPRKKTPEQLAKERAMKEIE 672
                                            ..|..|:.:||..:..||..|..|:||:..||.
Mouse   639 --------------------------------LALRGKKKRKKFMKDAKKKGEMTAEERSQFEIL 671

  Fly   673 KVSLVRAKMAKLRKRPGKLGAATEVHRSGASDGKPKRRGGQSAFTNDLTDVSRGGALRLRSEAN- 736
            |..:...::||..:|..:..|..|...:|.:  |.:::..:|.|..:||:.|:....:.|:..:
Mouse   672 KAQMFAERLAKRNRRTKRARAMPEDEPTGPA--KKQKQQQKSVFDEELTNTSKKALKQYRAGPSF 734

  Fly   737 RHKKMTKIAAKKKASSVKLTNKAGKNKFNKGK 768
            ..:|.:.:..:::.      |...|:::.:.|
Mouse   735 EERKQSGLPRQRRG------NFKSKSRYKRKK 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rs1	NP_001286188.1	PTZ00424	148..537	CDD:185609	265/388 (68%)
		DEADc	159..364	CDD:238167	144/204 (71%)
		Helicase_C	393..498	CDD:278689	78/104 (75%)
Ddx27	NP_694705.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50		12/44 (27%)
		Required for interaction with the PEBOW complex. /evidence=ECO:0000250\|UniProtKB:Q96GQ7	55..57		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	80..149		20/69 (29%)
		Nuclear localization signal. /evidence=ECO:0000255	157..166		3/8 (38%)
		SrmB	175..640	CDD:223587	294/510 (58%)
		Q motif	184..212		16/27 (59%)
		DEADc	186..390	CDD:238167	144/204 (71%)
		DEAD box	337..340		2/2 (100%)
		Helicase_C	415..524	CDD:278689	81/108 (75%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	605..624		7/18 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	679..760		16/88 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842623
Domainoid	1	1.000	248	1.000	Domainoid score	I2135
eggNOG	1	0.900	-	-		E2759_KOG0338
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6431
Inparanoid	1	1.050	612	1.000	Inparanoid score	I911
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004776
OrthoInspector	1	1.000	-	-		oto93891
orthoMCL	1	0.900	-	-		OOG6_102067
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R351
SonicParanoid	1	1.000	-	-		X2837
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.780