Protein Alignment Rs1 and Ddx27

DIOPT Version :10

• Sequence 1: NP_651970.1
• Gene: Rs1 / 44087
• FlyBaseID: FBgn0021995
• Length: 782
• Species: Drosophila melanogaster
• Sequence 2: NP_694705.2
• Gene: Ddx27 / 228889
• MGIID: 2385884
• Length: 760
• Species: Mus musculus
• Alignment Length: 812
• Identity: 373/812 - (45%)
• Similarity: 501/812 - (61%)
• Gaps: 106/812 - (13%)

  Fly     7 LDLIGTI--EDDAEVENLSEDSDAEVE------YQPTKLRHKKVTEFEKGFEFVSSVKEYNQDTW 63
            |..|.||  .|:..||..|:..|.|.|      .:...|:..:..:|...|.|......|: .:|
Mouse     5 LGFIRTIGENDEVPVEPESDSGDEEEEGPIVLGRKQKALQKNRSADFNPDFVFTEKEGMYD-GSW 68

  Fly    64 --DDLMKYVKRK-ARTKTDDKIAARLQKRGGAEAVAA-----EQSDG------------------ 102
              .|:|..:|:| |.|..|:|| .:::||..||...|     |:.:|
Mouse    69 ALADVMSQLKKKRAATTLDEKI-EKVRKRRKAEDKEAKSGKVEEKEGQADSDLKGQENPGEDEAG 132

  Fly   103 -----SEIDL-SEDE---LKHDNLRLREKKESKKKKKKAGEEDEEDEGEKMQFADTVEANEQITS 158
                 ||.|. ||||   .|.|.|:::|||:.||.:...|..::..|.:|.            .|
Mouse   133 SKDEDSETDYSSEDEEILTKADTLKVKEKKKKKKGQAAGGFFEDASEYDKS------------LS 185

  Fly   159 FYQMNLSRPLMRAIGVLGYIYPTPIQASTIPVALLGRDICGCAATGTGKTAAYMLPTLERLLYRP 223
            |..|||||||::||..:|:..|||||.:.|||.|||:|||.|||||||||||:.||.||||:|:|
Mouse   186 FQDMNLSRPLLKAITAMGFKQPTPIQKACIPVGLLGKDICACAATGTGKTAAFALPVLERLIYKP 250

  Fly   224 LNNKAITRVLVLVPTRELGAQVYQVTKQLCQFTTIDVGLAIGGLDVKAQEAVLRQNPDIVIATPG 288
             ...|:|||||||||||||.||:.|||||.||.:|...||:||||||:|||.||..|||:|||||
Mouse   251 -RQAAVTRVLVLVPTRELGIQVHSVTKQLAQFCSITTCLAVGGLDVKSQEAALRAAPDILIATPG 314

  Fly   289 RLIDHIKNTPSFTLDSIEVLILDEADRMLDEYFAEQMKEIINSCCKTRQTMLFSATMSEQVKDLA 353
            |||||:.|.|||.|.||||||||||||||||||.|||||||..|...||||||||||:::|||||
Mouse   315 RLIDHLHNCPSFHLSSIEVLILDEADRMLDEYFEEQMKEIIRMCSHHRQTMLFSATMTDEVKDLA 379

  Fly   354 AVSLDKPIKVFVNNNQQVAFNLRQEFIRIREDKEGDREPILASLICRTFHDHCMVFVQTKKQAHR 418
            :|||..|:::|||:|..||..|||||||||.::|||||.|:|:|:.|||.||.|:|.||||||||
Mouse   380 SVSLKNPVRIFVNSNTDVAPFLRQEFIRIRPNREGDREAIVAALLMRTFTDHVMLFTQTKKQAHR 444

  Fly   419 LHILLGLLGVRAGELHGNLTQQQRLESLKKFKEEQIDVLIATDVAARGLDIVGVKTVINFVMPIT 483
            :||||||||::.|||||||:|.||||:|::||:||||:|:|||||||||||.||||||||.||.|
Mouse   445 MHILLGLLGLQVGELHGNLSQTQRLEALRRFKDEQIDILVATDVAARGLDIEGVKTVINFTMPNT 509

  Fly   484 TEHYIHRVGRTARAGRAGISVSLAGEKERKIVKDIIKNAESTIKNRIIPPEIIEKYRNKLTSLEP 548
            .:||:|||||||||||||.||||.||:|||::|:|:|.|::.:|.||:|.::|.|:|:|:..||.
Mouse   510 VKHYVHRVGRTARAGRAGRSVSLVGEEERKMLKEIVKAAKAPVKARILPQDVILKFRDKIEKLEK 574

  Fly   549 EIQNILDEEQAERQLAKTEQQLSKTERKLLGQTNE------RRGWFQTKQQREAEKDRLALTTGD 607
            ::..:|..|..|:::.::|.|:. |.::||.:..|      .|.|||||::|:.||...||...|
Mouse   575 DVYAVLQLEAEEKEMQQSEAQID-TAQRLLAKGKETADQEPERSWFQTKEERKKEKIAKALQEFD 638

  Fly   608 EDKASGGKGKGKTAGKRKRPEYGGDGEDGPPVKDLEAKRNKKKKEEPRKKTPEQLAKERAMKEIE 672
                                            ..|..|:.:||..:..||..|..|:||:..||.
Mouse   639 --------------------------------LALRGKKKRKKFMKDAKKKGEMTAEERSQFEIL 671

  Fly   673 KVSLVRAKMAKLRKRPGKLGAATEVHRSGASDGKPKRRGGQSAFTNDLTDVSRGGALRLRSEAN- 736
            |..:...::||..:|..:..|..|...:|.:  |.:::..:|.|..:||:.|:....:.|:..:
Mouse   672 KAQMFAERLAKRNRRTKRARAMPEDEPTGPA--KKQKQQQKSVFDEELTNTSKKALKQYRAGPSF 734

  Fly   737 RHKKMTKIAAKKKASSVKLTNKAGKNKFNKGK 768
            ..:|.:.:..:::.      |...|:::.:.|
Mouse   735 EERKQSGLPRQRRG------NFKSKSRYKRKK 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rs1	NP_651970.1	SrmB	156..576	CDD:440279	277/419 (66%)
Ddx27	NP_694705.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50		12/44 (27%)
		Required for interaction with the PEBOW complex. /evidence=ECO:0000250|UniProtKB:Q96GQ7	55..57		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	80..149		20/69 (29%)
		Nuclear localization signal. /evidence=ECO:0000255	157..166		3/8 (38%)
		Q motif	184..212		16/27 (59%)
		SrmB	185..574	CDD:440279	270/389 (69%)
		DEAD box	337..340		2/2 (100%)
		MPH1	<463..750	CDD:440728	122/327 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	605..624		7/18 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	679..760		16/88 (18%)