DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rs1 and ddx-27

DIOPT Version :9

Sequence 1:	NP_001286188.1	Gene:	Rs1 / 44087	FlyBaseID:	FBgn0021995	Length:	782	Species:	Drosophila melanogaster
Sequence 2:	NP_490891.2	Gene:	ddx-27 / 171743	WormBaseID:	WBGene00022148	Length:	739	Species:	Caenorhabditis elegans

Alignment Length:	802	Identity:	334/802 - (41%)
Similarity:	470/802 - (58%)	Gaps:	108/802 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 LSEDSDAEVEYQPTKLRHKK-----VTEFEKGFEFVSSVKEYNQDTWDDLMKYVKRKARTKTDDK 81
            :.|..|.:|:.:...:|.||     ..||.:.|.|.|...::.....:||.||:|::..|..|:|
Worm     3 IDESDDEQVQDEAVTVRKKKKMANAAEEFAQDFIFESGDTQFIDRETEDLQKYLKKQTPTSLDEK 67

  Fly    82 IA--ARLQKRGGAEAV--AAEQSDGSEIDLSEDELKHDNLRLREKKESKKKKKKAGEEDEEDEGE 142
            ||  .:|:..|.|..|  .||.::..|.|..||:::  .|..:|.:::.::|:|:|:..:..|.|
Worm    68 IAEMRKLKNTGKAVIVEDEAEAAEAEEKDEEEDDVQ--QLGGKETRDTVREKRKSGKSKKSQENE 130

  Fly   143 KMQFADTVEANEQIT----SFYQMNLSRPLMRAIGVLGYIYPTPIQASTIPVALLGRDICGCAAT 203
            .. |:..::.....|    ||.||||||.:::|....||..|||||.:.|||||.|:|||.||||
Worm   131 DF-FSALIDGKSLDTSVNVSFEQMNLSRQILKACSGAGYSDPTPIQQACIPVALTGKDICACAAT 194

  Fly   204 GTGKTAAYMLPTLERLLYRPLNNKAITRVLVLVPTRELGAQVYQVTKQLCQFTTIDVGLAIGGLD 268
            |||||||::||.|||::||| ...:.||||||||||||..||:||.::|..|..::|.|..||||
Worm   195 GTGKTAAFVLPILERMIYRP-KGASCTRVLVLVPTRELAIQVFQVFRKLSTFIQLEVCLCAGGLD 258

  Fly   269 VKAQEAVLRQNPDIVIATPGRLIDHIKNTPSFTLDSIEVLILDEADRMLDEYFAEQMKEIINSCC 333
            :|||||.||..||:|:|||||||||:.|:|||.|.:||||:||||||||:|.|.:||.|:|..|.
Worm   259 LKAQEAALRSGPDVVVATPGRLIDHLHNSPSFNLSNIEVLVLDEADRMLEEAFRDQMNELIRLCA 323

  Fly   334 KTRQTMLFSATMSEQVKDLAAVSLDKPIKVFVNNNQQVAFNLRQEFIRIREDKEGDREPILASLI 398
            :.|||:||||||:|::.:||::||.||:|:|:|.|...|..|||||||||..:|.|||.::|:|:
Worm   324 QNRQTLLFSATMTEEIDELASMSLQKPVKIFINENTDTALKLRQEFIRIRAGRETDREAMVAALV 388

  Fly   399 CRTFHDHCMVFVQTKKQAHRLHILLGLLGVRAGELHGNLTQQQRLESLKKFKEEQIDVLIATDVA 463
            .|||..:.:|||:|||...|:.|||||||::.|::..:|||.||:|||.|||:.:||||::||:|
Worm   389 TRTFQTNTIVFVRTKKDCQRMQILLGLLGIKVGQMQSSLTQGQRIESLSKFKKAEIDVLVSTDLA 453

  Fly   464 ARGLDIVGVKTVINFVMPITTEHYIHRVGRTARAGRAGISVSLAGEKERKIVKDII-KNAESTIK 527
            :|||||.||:||||..||.:.:.||||||||||||:||.|:||.||.|||::|:|: .||:.|:|
Worm   454 SRGLDIEGVQTVINMNMPKSIKQYIHRVGRTARAGKAGRSISLVGEDERKLLKEIVNSNADRTLK 518

  Fly   528 NRIIPPEIIEKYRNKLTSLEPEIQNILDEEQAERQLAKTEQQLSKTERKL-LGQTN----ERRGW 587
            .|::.||::|.||.::..||..||.|.:|::||::|...|..::||:..| :|:..    |||.|
Worm   519 QRLVAPEVVEAYRRRIDELEETIQQIDEEDRAEKELRIAEASMAKTQNALEVGENGGAPAERRVW 583

  Fly   588 FQTKQQREAEKDRLALTTGDEDKASGGKGKGKTAGKRKRPEYGGDGEDGPPVKDLEAKRNKK--- 649
            ...:.|.|.::.|                                          |.||..|
Worm   584 MMKESQIEKQRKR------------------------------------------EEKRQMKVDA 606

  Fly   650 KKEEPRKKTPEQLAKERAMKEIEKVSLVRAKMAKLRKRPGKLGAATEVHRSGASDGKPK----RR 710
            :|:....||||.:       :||..:....:.|| |.|..|......|..|..:.|..|    ::
Worm   607 RKKAEAAKTPEDI-------QIEHEAAFHVRAAK-RARHSKNKRIRAVVESAGTKGAGKAAQNKK 663

  Fly   711 GGQSAFTNDLTDV------SRGGALRLRSEANRHKKMTKIAAKK-----KASSVKLTNKAGK--- 761
            ...|.....|.|:      |||        ..:.:|..|..|||     .||..|.:.||.:
Worm   664 KASSNSKTSLRDIPLVNAGSRG--------VQKAQKGQKPGAKKGFTSALASVSKKSVKAARHGP 720

  Fly   762 --NKFNKGKNFGGPRHAKKDKK 781
              :||.|.:    ..|..|.||
Worm   721 EDSKFQKAR----VAHRMKTKK 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rs1	NP_001286188.1	PTZ00424	148..537	CDD:185609	228/393 (58%)
		DEADc	159..364	CDD:238167	127/204 (62%)
		Helicase_C	393..498	CDD:278689	61/104 (59%)
ddx-27	NP_490891.2	SrmB	128..609	CDD:223587	259/524 (49%)
		DEADc	150..354	CDD:238167	127/204 (62%)
		Helicase_C	379..488	CDD:278689	64/108 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162513
Domainoid	1	1.000	224	1.000	Domainoid score	I1454
eggNOG	1	0.900	-	-		E2759_KOG0338
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6431
Inparanoid	1	1.050	545	1.000	Inparanoid score	I628
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28876
OrthoDB	1	1.010	-	-		D268859at2759
OrthoFinder	1	1.000	-	-		FOG0004776
OrthoInspector	1	1.000	-	-		oto17314
orthoMCL	1	0.900	-	-		OOG6_102067
Panther	1	1.100	-	-	LDO	PTHR24031
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R351
SonicParanoid	1	1.000	-	-		X2837
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800