DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DCTN2-p50 and Dctn2

DIOPT Version :9

Sequence 1:	NP_524690.1	Gene:	DCTN2-p50 / 44086	FlyBaseID:	FBgn0021825	Length:	380	Species:	Drosophila melanogaster
Sequence 2:	NP_001177383.1	Gene:	Dctn2 / 69654	MGIID:	107733	Length:	407	Species:	Mus musculus

Alignment Length:	406	Identity:	133/406 - (32%)
Similarity:	216/406 - (53%)	Gaps:	37/406 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADPKFQNLPGIAYDQPDVYETPDDPELDTSDYYE-----EEPENEAIERLHISPSVAHKRFSGA 60
            |||||:.:|||||.::||||||.|.||.|.:::..     ||..:.::|.:.::|:.|:.:|...
Mouse     1 MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAFAQELEELSSTSVEHIIVNPNAAYDKFKDK 65

  Fly    61 TV-EGSVDFTDRIGRRMCRGYDTRGSSDYELVGQ--GEKETPVQKCQRLQIEMNELLNEVAALQV 122
            .| ...:||:||||:....||:   |.|||::|:  |.||||.||.|||..|:.||..||..::.
Mouse    66 RVGTKGLDFSDRIGKTKRTGYE---SGDYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKT 127

  Fly   123 D-RKVADEEKQSYDAVATVISTARKVLESLKLEQVLGKEQT-----PGSKQVKALISQVEEFKQS 181
            . ::.|.|||.:...:|..::..::.|.:..||::||.:..     |.....|.|:.|:|..|.|
Mouse   128 TVKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLADPDGALAKRLLLQLEATKSS 192

  Fly   182 -----GVLTAIPTPGTDL--------------AATARVASLEQRISQLEKVLGAQPDKLSRLTAA 227
                 |..||...|.:.|              :..|:||.||:|:::||..:....|..:.|:|.
Mouse   193 KGSSGGKATAGAPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEATVRCDQDAQNPLSAG 257

  Fly   228 TNTTNVLEAVRHLSTKAALIQPDKLDTIEQRLTSLAGKMDAIAEKSSGSAQDAKRDQKITELYDI 292
            .....::|.|..|..|.:.:....||.:|.||.|:.||::.|| |...|.:||....|:.:||:.
Mouse   258 LQGACLMETVELLQAKVSALDLAVLDQVEARLQSVLGKVNEIA-KHKASVEDADTQNKVHQLYET 321

  Fly   293 AKRTEPVVEILPHVIERMQALEALHKYANNFAKIIAEIEQKQGTITTSLVNNKELLHSVQETFAQ 357
            .:|..||...||.:::|:..::.||:.|..|.:::..::..|..:.:||.:|..||..||.|..:
Mouse   322 IQRWSPVASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMMASSLKDNTALLTQVQTTMRE 386

  Fly   358 NLETINSKVAKVEQRV 373
            ||.|:....|.::.|:
Mouse   387 NLATVEGNFASIDARM 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCTN2-p50	NP_524690.1	Dynamitin	16..376	CDD:282730	123/391 (31%)
Dctn2	NP_001177383.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		17/25 (68%)
Dctn2	NP_001177383.1	Dynamitin	16..405	CDD:282730	123/391 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849985
Domainoid	1	1.000	185	1.000	Domainoid score	I3392
eggNOG	1	0.900	-	-		E1_KOG3958
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4667
Inparanoid	1	1.050	206	1.000	Inparanoid score	I3717
Isobase	1	0.950	-	0	Normalized mean entropy	S5879
OMA	1	1.010	-	-		QHG55390
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007427
OrthoInspector	1	1.000	-	-		oto94679
orthoMCL	1	0.900	-	-		OOG6_103885
Panther	1	1.100	-	-	LDO	PTHR15346
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2476
SonicParanoid	1	1.000	-	-		X6311
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740