DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DCTN2-p50 and Dctn2

DIOPT Version :9

Sequence 1:	NP_524690.1	Gene:	DCTN2-p50 / 44086	FlyBaseID:	FBgn0021825	Length:	380	Species:	Drosophila melanogaster
Sequence 2:	XP_017450231.1	Gene:	Dctn2 / 299850	RGDID:	1303182	Length:	407	Species:	Rattus norvegicus

Alignment Length:	406	Identity:	132/406 - (32%)
Similarity:	214/406 - (52%)	Gaps:	37/406 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MADPKFQNLPGIAYDQPDVYETPDDPELDTSDYYE-----EEPENEAIERLHISPSVAHKRFSGA 60
            |||||:.:|||||.::||||||.|.||.|.:::..     ||..:.::|.:.::|:.|:.:|...
  Rat     1 MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAFAQELEELSSTSVEHIIVNPNAAYDKFKDK 65

  Fly    61 TV-EGSVDFTDRIGRRMCRGYDTRGSSDYELVGQ--GEKETPVQKCQRLQIEMNELLNEVAALQV 122
            .| ...:||:||||:....||:   |.|||::|:  |.||||.||.|||..|:.||..||..::.
  Rat    66 RVGTKGLDFSDRIGKTKRTGYE---SGDYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKIKT 127

  Fly   123 D-RKVADEEKQSYDAVATVISTARKVLESLKLEQVLGKEQT-----PGSKQVKALISQVEEFKQS 181
            . ::.|.|||.:...:|..::..::.|.:..||::||.:..     |.....|.|:.|:|..|.|
  Rat   128 TVKESATEEKLTPVVLAKQLAALKQQLVASHLEKLLGPDAAINLADPDGALAKRLLLQLEATKSS 192

  Fly   182 -----GVLTAIPTPGTDL--------------AATARVASLEQRISQLEKVLGAQPDKLSRLTAA 227
                 |..|....|.:.|              :..|:||.||:|:::||..:....|..:.|:|.
  Rat   193 KGSSGGKSTGGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELEATVRCDQDAQNPLSAG 257

  Fly   228 TNTTNVLEAVRHLSTKAALIQPDKLDTIEQRLTSLAGKMDAIAEKSSGSAQDAKRDQKITELYDI 292
            .....::|.|..|..|...:....||.:|.||.|:.||::.|| |...|.:||....|:.:||:.
  Rat   258 LQGACLMETVELLQAKVNALDLAVLDQVEARLQSVLGKVNEIA-KHKASVEDADTQNKVHQLYET 321

  Fly   293 AKRTEPVVEILPHVIERMQALEALHKYANNFAKIIAEIEQKQGTITTSLVNNKELLHSVQETFAQ 357
            .:|..||...||.:::|:..::.||:.|..|.:::..::..|..:.:||.:|..||..||.|..:
  Rat   322 IQRWSPVASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMMASSLKDNTALLTQVQTTMRE 386

  Fly   358 NLETINSKVAKVEQRV 373
            ||.|:....|.::.|:
  Rat   387 NLATVEGNFASIDARM 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DCTN2-p50	NP_524690.1	Dynamitin	16..376	CDD:282730	122/391 (31%)
Dctn2	XP_017450231.1	Dynamitin	16..405	CDD:398533	122/391 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353663
Domainoid	1	1.000	182	1.000	Domainoid score	I3370
eggNOG	1	0.900	-	-		E1_KOG3958
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4667
Inparanoid	1	1.050	203	1.000	Inparanoid score	I3673
OMA	1	1.010	-	-		QHG55390
OrthoDB	1	1.010	-	-		D421732at33208
OrthoFinder	1	1.000	-	-		FOG0007427
OrthoInspector	1	1.000	-	-		oto98187
orthoMCL	1	0.900	-	-		OOG6_103885
Panther	1	1.100	-	-	LDO	PTHR15346
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6311
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770