DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CAPN14 and RIM13

DIOPT Version :9

Sequence 1:	NP_001138594.1	Gene:	CAPN14 / 440854	HGNCID:	16664	Length:	684	Species:	Homo sapiens
Sequence 2:	NP_013875.1	Gene:	RIM13 / 855186	SGDID:	S000004763	Length:	727	Species:	Saccharomyces cerevisiae

Alignment Length:	341	Identity:	73/341 - (21%)
Similarity:	124/341 - (36%)	Gaps:	89/341 - (26%)

- Green bases have known domain annotations that are detailed below.

Human    57 GSGSLLQKLPPRLQWKRPPELHSNPQFYFAKAKRLDLCQGIVGDCWFLAAL-------QALALHQ 114
            |:..|.::.|.|.:.:       |.:.|   :..::.|:. |.||..:|:|       ..|.|.:
Yeast    95 GTEELQRRYPGRAKLQ-------NEEDY---SGGIEQCRD-VPDCSLVASLINLRSKNLNLPLIK 148

Human   115 DILSRVVPLNQSFTEKYAGIFRFWFWHYGNWVPVVID-DRLPVNEAGQLVFVSSTYKNLFWGALL 178
            .|.|....:|.||             :..|...|.:| .::|.:..|:.:.:.|   |.....:.
Yeast   149 QISSTKYHVNLSF-------------NGSNKRLVTVDISQIPTSVDGKQLSLKS---NDISDKIG 197

Human   179 EKAYAKLS-GSYEDLQSGQVSEALVDFTGGVTMTINLAEAHGNLWDILIEATY-----------N 231
            |.|...:| |:|.              |.|..::|:.....|.|.:|....:|           |
Yeast   198 ELALLLVSKGTYS--------------TDGSNISIDTYRLSGFLPEITQVNSYPFEKLWKFHKSN 248

Human   232 RTLIGCQTHSGEKILENGLVEGHAYTLTGIRKVTCKHRPEYLVKLRNPWGKV--------EWKGD 288
            ..|:|..|.:....:...|||.|.|::..|   |...|   |||||:|....        ::..:
Yeast   249 LCLMGAGTGNRSNDMIKPLVENHDYSIIDI---TYDSR---LVKLRDPRNSALNVEISYEQYLKN 307

Human   289 WSDSSSKW--ELLSPKEKILLLRKDNDGEFWMTLQDFKTHFVLLVICKLTPGLLSQEAAQKW--- 348
            :......|  |.|..:.::|..|.|.......::...|..|.|:...|:|..:        |
Yeast   308 FKQLYLNWNQEKLFKRSQVLHFRYDTSRYNKFSIVADKPLFHLVNNSKVTETV--------WLLL 364

Human   349 -TYTMREGRWEKRSTA 363
             ::...||..|.||.:
Yeast   365 ESHLQDEGSQENRSVS 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAPN14	NP_001138594.1	Peptidase_C2	44..334	CDD:279042	65/306 (21%)
		Domain III	337..503		6/31 (19%)
		Calpain_III	348..496	CDD:279416	6/20 (30%)
		Linker	504..517
		Domain IV	518..683
		EFh	562..616	CDD:298682
RIM13	NP_013875.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810