DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CAPN14 and si:ch211-202f3.3

DIOPT Version :9

Sequence 1:	NP_001138594.1	Gene:	CAPN14 / 440854	HGNCID:	16664	Length:	684	Species:	Homo sapiens
Sequence 2:	XP_017207337.2	Gene:	si:ch211-202f3.3 / 553353	ZFINID:	ZDB-GENE-080917-19	Length:	846	Species:	Danio rerio

Alignment Length:	683	Identity:	252/683 - (36%)
Similarity:	376/683 - (55%)	Gaps:	44/683 - (6%)

- Green bases have known domain annotations that are detailed below.

Human    28 QDFEALLAECLRNGCLFEDTSFPATLSSIGSGSLLQKLPPRLQWKRPPELHSN-PQFYFAKAKRL 91
            ||:..|...||:....|.|..||..|.|||.|.|..::..|::|.||.:|:.. .:|......|.
Zfish   182 QDYNFLQDYCLKTRQRFVDEFFPPDLRSIGEGLLKPEVMARVEWIRPTKLYPEAAEFVVDTVSRF 246

Human    92 DLCQGIVGDCWFLAALQALALHQDILSRVVPLNQSFTEKYAGIFRFWFWHYGNWVPVVIDDRLP- 155
            |..||.:|:|||||::.||.....:|.:|||..||....|.|:|.|.||.:|.|..|||||:||
Zfish   247 DYAQGFIGNCWFLASVGALTFQSKLLQKVVPDGQSLRHNYTGLFHFRFWRFGKWFDVVIDDKLPT 311

Human   156 VNEAGQLVFVSSTYKNLFWGALLEKAYAKLSGSYEDLQSGQVSEALVDFTGGVTMTINLAEAHGN 220
            :|.  ||:||.|...|.||.|||||||||:.|||.|:.:|:|||||:||||||.|..:|..|..:
Zfish   312 INR--QLIFVKSKTYNEFWPALLEKAYAKVCGSYADMHTGRVSEALLDFTGGVHMHYDLKTAPTD 374

Human   221 LWDILIEATYNRTLIGCQTHSG-EKILENGLVEGHAYTLTGIRKVTCKHRPEYLVKLRNPWGKVE 284
            ||:|:..|:.:..|:||::.:| |:.|.||:|.|||||:|.:.:|.....|..||:|.||||..|
Zfish   375 LWEIMYRASQSEVLMGCESPAGNEERLPNGIVLGHAYTVTKVYQVMSGRNPVQLVRLFNPWGDSE 439

Human   285 WKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTLQDFKTHFVLLVICKLTPGLLSQEAAQKWT 349
            |.|||||:|..|..:..:::..||..|| |||||:::||...|..:.||...|..|..::|.|||
Zfish   440 WNGDWSDNSPLWNTVDDEDRKQLLVSDN-GEFWMSMKDFLRTFDNMDICCNCPDFLEGKSACKWT 503

Human   350 YTMREGRWEKRSTAGGQRQLLQDTFWKNPQFLLSVWRPEEGRRSLRPC-----SVLVSLLQKPRH 409
            .....|.|...|||||... ..|||..||||.|.:...:      :.|     :|||||:|||..
Zfish   504 SKSHNGSWVPGSTAGGCMN-HPDTFCTNPQFWLRINEMD------KTCDQGQNNVLVSLIQKPDK 561

Human   410 RCRKRKPLLAIGFYLYRMNKYHDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIV 474
            |.|:......|||.::.:......:.:....||.|. |:.....|...::|.:...||||.||||
Zfish   562 RNRRLAQHHGIGFCVFAVPPEMRSEGKFRSSFFNRK-PVVTSGNFQDARQVMKFFRLEPGEYLIV 625

Human   475 PCILEAHQKSEFVLRVFSRKHIFYE--------------IG-SNSGVVFSKEIEDQNERQDEFFT 524
            |.....::.::|:|.:..:..|..:              || |.||..   |.||:..:....|.
Zfish   626 PSTYLPNKNADFILSILCKNDIQIQKDTERTEKDFLVDLIGVSESGCT---EKEDEESKTKFLFR 687

Human   525 KFFEKHPEINAVQLQNLLNQMTWSSLGSRQ--PFFSLEACQGILALLDLNASGTMSIQEFRDLWK 587
            ::.:::..::|.:||.:|::   :.|..|:  ..|.|::|:.::|:.|...:|.:...||..||.
Zfish   688 QYSDQYKVVDAEKLQQILHE---NLLRGRKNAEGFGLDSCRSMIAMSDFCVTGRLQGSEFVRLWD 749

Human   588 QLKLSQKVFHKQDRG-SGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLML 651
            ::...:.:|:..|.. .|.|:..:|..|:.:.|:.|::|:..||::||||...|:....||.|::
Zfish   750 RITTYRDIFYNMDSSKDGVLSLNELQNALEKTGLHLNEDILNLMVVRYGGASEQISLEGFICLVM 814

Human   652 RVENMEDVFQNLTQDGKGIYLQKPEWMMMALYS 684
            |:..|..:||.|.::|| |.|.:.||:.:.:||
Zfish   815 RLNCMASIFQKLCENGK-ISLDESEWIGLTMYS 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAPN14	NP_001138594.1	Peptidase_C2	44..334	CDD:279042	136/292 (47%)
		Domain III	337..503		55/185 (30%)
		Calpain_III	348..496	CDD:279416	48/152 (32%)
		Linker	504..517		5/12 (42%)
		Domain IV	518..683		47/167 (28%)
		EFh	562..616	CDD:298682	14/54 (26%)
si:ch211-202f3.3	XP_017207337.2	Peptidase_C2	198..487	CDD:306994	135/291 (46%)
		Calpain_III	509..647	CDD:307285	46/145 (32%)
		EFh_PEF_CAPN13_14	683..846	CDD:320070	47/166 (28%)
		EF-hand motif	683..709	CDD:320070	5/28 (18%)
		EF-hand motif	723..752	CDD:320070	8/28 (29%)
		EF-hand motif	753..783	CDD:320070	6/29 (21%)
		EF-hand motif	789..817	CDD:320070	11/27 (41%)
		EF-hand motif	819..846	CDD:320070	10/27 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194328334
Domainoid	1	1.000	281	1.000	Domainoid score	I8178
eggNOG	1	0.900	-	-		E1_KOG0045
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG41242
OrthoDB	1	1.010	-	-		D704215at2759
OrthoFinder	1	1.000	-	-		FOG0000071
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_116862
Panther	1	1.100	-	-	O	PTHR10183
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X74
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.720