DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcr and c4b

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:NP_001352066.1 Gene:c4b / 794635 ZFINID:ZDB-GENE-100805-2 Length:1717 Species:Danio rerio


Alignment Length:1811 Identity:350/1811 - (19%)
Similarity:667/1811 - (36%) Gaps:512/1811 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   144 LIYQVSVSILQAQYPITVHASIACDGVQIS----------GDSKDVK----EGIPETLLMRIPPT 194
            ||...||..:..:.||.:....|..|..:|          ..:|:.|    :|..||:.:.|...
Zfish    28 LITAPSVFHVGVKEPIVIQVGEALVGKPVSCQLETETRVPMSAKETKTIHQKGKFETVNLEIFAN 92

  Fly   195 SVTGSYKLRVEGFYQN----VFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPIT 255
            :|:....:..|..|.|    |.|.   ..:||:..|:.:..||:|||:|:|...:.||||...:.
Zfish    93 TVSNLKSINGEPPYLNLACEVDGQ---RQQTRVLVSKHNGYIFIQTDQPIYNPTQKVRFRIFTLD 154

  Fly   256 TELKGFDNP-------VDVYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQG 313
            ..::    |       |.:|..|.|:  :|:...|..: |.:|.:||:.|....|.|.|....:.
Zfish   155 HSMR----PKLEMYVYVSIYNADGNK--VKKSKYRVLD-GILSKDYKIPDVSKPGVWKITAHYED 212

  Fly   314 QQEES---HFTVEEYYQTRFEVNV-TMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPI 374
            ..:.:   .|.|:::....|.|:| :..|:.......:...:.|:::.|..:.|....:..|:. 
Zfish   213 DVDNAAVREFKVQKFVLPSFGVSVHSEKAFLQANAKTLTFTIQASYSYGKTIDGGFHCRFGIKK- 276

  Fly   375 GYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQY 439
                          |:|                 ..:|:::: :.|                   
Zfish   277 --------------GKS-----------------ENDPEIEF-IKG------------------- 290

  Fly   440 VVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLAN 504
             :|:                         :|:.::.|..:     |.:.....::|:..:..||.
Zfish   291 -LEK-------------------------TGSVKEGLAKI-----TVNISDITQKLDTALEELAT 324

  Fly   505 SEV--LITATV----------GEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYL 557
            ::.  .|:|||          .|.|...::|.|:|.           |..:...:.||.|....:
Zfish   325 TQTQFYISATVTDILSGEVQESETFLPVVLSRYNVD-----------LSRTRLFYTPAFPLQAVV 378

  Fly   558 AVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDIRN------ 616
            .|.:.:|||                                     ::|: :||:|:.|      
Zfish   379 TVRHPNGSP-------------------------------------AEGV-QVKLDVSNSKEKST 405

  Fly   617 ------------DLNLDDRPQARDFLNGVQNMRLQANFVDPRGERI-----QTELLLVSHYSPRN 664
                        ..|||.:|         .::.:||...:.:..|.     .|..|.:|..:   
Zfish   406 IVTTNKEGIAFYSFNLDGKP---------PSVLVQATVDNAKSIRAVHPMKSTSFLYMSVTN--- 458

  Fly   665 QHIKVTTSTEKPVVGEYIIFHIRTNFYLE------EFNYLIMSKGVILVNDRET--ITEG--IKT 719
               ||.:|      |::    :..:||.:      :..|:|:|:|::    |.|  :..|  :|.
Zfish   459 ---KVLSS------GQF----LEVSFYPKGNPEDGQIYYMIVSRGML----RSTGSVASGSEVKK 506

  Fly   720 IAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYI------NNRKARTGEKVE 778
             ::.:...|.|...::.:...::|.::|||:...|.......|.|.:      :|.:..:..:::
Zfish   507 -SIQIHPNMTPSFRLIAFYYIKEGDIIADSVWVDVEDTCDGEFEVKLHHNYGNHNYEPESTAELD 570

  Fly   779 VAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFD--------EQTNGTYKHIWYSHE 835
            :.:..:..:.|.|..:|.|.|.:.|.|:||..::...|.::|        |.|...:        
Zfish   571 IDVGQQKNAKVALQVVDKAIYALGAQNKLTQKQVFASMKSYDLGCSYGGGENTAAVF-------- 627

  Fly   836 GNPDELVYFPASSF-------GVDANRTFEYSGLIVFTDGYVPRRQDTCNRTLGFGECLSGRCYR 893
             |...|.:...|:.       |......|..:...:.....:.|::....:|            .
Zfish   628 -NDAGLAFISHSTTIRSAMRKGFSCESGFRRNKREIDVQAEMARKEAAFKKT------------E 679

  Fly   894 LEKQC-DGL------FDCDD------GTDEINC--------------------------HAR--N 917
            |:|.| .|.      |.||:      .|:..:|                          |.|  |
Zfish   680 LQKCCRHGFTLIPMKFTCDERAKRVSKTESKDCVNAFRECCEFATKLRDKKRREDMRTGHGRTIN 744

  Fly   918 DTELLNYRKYRFNRVLRHYENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMM 982
            ..|:..:..:....:..::...:.:|.:::  .|:....:.:|.....|.:.|.|:|||.|| .:
Zfish   745 SNEVEEFFDFEIQNIRHYFPPSFEFKQIDV--KGKVRHRIHLPHSITTWEIQALSLSPSHGF-CV 806

  Fly   983 NKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIV 1047
            .:.::....:|.||::.:|.:.::.||:.|...:|||....:|.:|.:.          :.||:.
Zfish   807 AEPVDLTAFKPVFISLRLPYSVKRYEQLSIVAVIFNYGKMEMELVVRMR----------QVDGLC 861

  Fly  1048 RSYNPRTSFGEHQFFIYLEAQGTTVVYVPVVPQRLGNVDVTLHVATL---LGTDTITRTLHVESD 1109
               :|.::.........|:...:..|..|.||...|.:.:|:.:..:   :..|.|.:.|.|:::
Zfish   862 ---SPGSATSSSSVRFSLKPASSQTVTFPAVPMVKGEIPITIAIYDIEEKIEVDAIQKILLVKNE 923

  Fly  1110 GLPQYRHQSVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTM 1174
            |:......:.|::|.                             |.:..|:|:.|.......|..
Zfish   924 GVEMREELTYLINLD-----------------------------GRSDHRLSINGFFPNNTVPET 959

  Fly  1175 PVN-----------------------ASSLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTL 1216
            .||                       ..:|:..|...|||.....:....:|.|:.. :||...|
Zfish   960 DVNLFVKLEEEIFAQSTAVPLLSSSKVENLIQAPKGCGEQTMIFMSPTALSIRYLDK-SQRWLEL 1023

  Fly  1217 E----KNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQ---EASFYEWE 1274
            |    ..|...:...|:|.|:|.:.|||:..    |..:.:|.|||:..::|..   |......:
Zfish  1024 EAGSRDKALDFIEQAYERILTFKKTDGSYGA----WIQTPTSTWLTALVVKVLSLVAERQIETRQ 1084

  Fly  1275 NFIWIDATIIEKNMR----WLLQHQTPQGSFFEVTWLPDRKMNR--TNFDKNITLTSHVLITLAT 1333
            .....:..|.::::|    :|::.|...|||.:...:..|:|..  ...:::.:||:.:.|.|..
Zfish  1085 QHGTTERMISQEDIRQAVTYLIKTQRSDGSFTDAHPVYHREMQGGIGGVEQDASLTAFITIALCR 1149

  Fly  1334 VKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVAITAYALQLCNSPIAEEVFAI----- 1393
            .........:.|:.:..||..::.:.:|.|:   :|:.:|||||.|..|   :.|...|:     
Zfish  1150 SMPFLDQEATAVSQSIARATNFLLKRVDNLK---RPYALAITAYCLSTC---LTERTQALSAWKK 1208

  Fly  1394 LRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREF-FV 1457
            |:...:..||.:.|.:.:    ..:|.|:.  ...|:|:.. :|.:||||||||..:|..:. ..
Zfish  1209 LQSLGKPEGDCLVWQDDD----DVRLVNEA--KSNRVPHRV-ALKVETTAYALLTALAHSDLKTA 1266

  Fly  1458 DPIVRWLNSQRLNDGGWASTQDTSAALKALVEY------------------TVRSRLR----EVS 1500
            ...|.:|:||...:||:.|||||..||:||.||                  |.||.:.    |.|
Zfish  1267 QSAVCFLSSQENYEGGFKSTQDTIVALEALSEYALSLPETPITTINAQFTVTGRSEMEKMNLEKS 1331

  Fly  1501 SLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIK-------------VQAKGAGYAIL 1552
            ...||.|.....|:...:.:.....||:   ::..|:.|:|             |..|....:::
Zfish  1332 ENKVEAELKRLVGQEINVNLSGKGKAKM---KVAKAYYTLKEDGNCADLSINVTVVGKVEYTSVV 1393

  Fly  1553 QMHVQYNVD---IEKFQTKPPVPAFGLHTKAIFHGRN----------QSHISYVACQNWINQNES 1604
            |....|..|   .|:...:..:|...:..   |..|:          :..:.|..|   ::..:.
Zfish  1394 QEDYNYYEDYGQAEETNEEEDLPRSAIEW---FDARSRQKRETSKNTKEDVVYTVC---VSHTQG 1452

  Fly  1605 ER-SGMAVLDVAIPTGYW-----IQQQK--LDTYVLSNRVRNLRRARYLERKIVFYFDYLDHEDI 1661
            .: ||||:.|:.:.:|:.     :::.|  :|.|:....|...|        ::.||:.:|..:.
Zfish  1453 RKLSGMAIADITLLSGFEAINTDLEKLKGLVDKYISHYEVTRGR--------VLLYFNEIDGGEA 1509

  Fly  1662 CVNFTIERWYPVANMSRYLPVRIYDYYAPERFNESIFDALPTYLLNICEVCGSSQC 1717
            |:.|..|:..|: .:.:..|...||||.|:|....::.| |.....:..:|....|
Zfish  1510 CIAFGAEQSVPI-GLVQPAPALFYDYYEPDRRCSVLYSA-PKRSKMVSVLCSDDVC 1563

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 29/109 (27%)
A2M_N_2 669..799 CDD:285005 27/145 (19%)
LDLa 886..913 CDD:238060 8/39 (21%)
A2M 940..1030 CDD:278630 23/89 (26%)
ISOPREN_C2_like 1177..1490 CDD:298658 88/354 (25%)
A2M_comp 1226..1492 CDD:284982 77/298 (26%)
A2M_recep 1607..1695 CDD:284981 25/94 (27%)
c4bNP_001352066.1 A2M_N 130..224 CDD:307790 27/100 (27%)
A2M_N_2 452..593 CDD:311575 31/161 (19%)
ANATO 667..735 CDD:237984 11/79 (14%)
A2M 772..854 CDD:306673 22/84 (26%)
complement_C3_C4_C5 982..1299 CDD:239226 87/334 (26%)
A2M_recep 1456..1545 CDD:311553 25/97 (26%)
NTR_complement_C4 1563..1715 CDD:239639 1/1 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
54.880

Return to query results.
Submit another query.