DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcr and si:dkey-46g23.2

DIOPT Version :9

Sequence 1:	NP_524688.1	Gene:	Mcr / 44071	FlyBaseID:	FBgn0267488	Length:	1760	Species:	Drosophila melanogaster
Sequence 2:	XP_021327775.1	Gene:	si:dkey-46g23.2 / 793100	ZFINID:	ZDB-GENE-070705-476	Length:	1359	Species:	Danio rerio

Alignment Length:	1549	Identity:	349/1549 - (22%)
Similarity:	613/1549 - (39%)	Gaps:	299/1549 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 VFGGLAF--LNETRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPITTELKGFDNPVDVYMLDPN 273
            |..|.:|  ..|.::.|.......|:|||||||..|:||.||.:.::.:|...|...::.:|:..
Zfish    24 VVQGQSFKMTEERKVMFRSYLPLTFIQTDKPLYNPGQTVNFRVVTMSDKLVPLDQMYNLVVLEDF 88

  Fly   274 RHI-LKRWLSRQSNLGSVS----LEYKLSDQPTFGEWTIRVIAQGQQEESHFTVEEYYQTRFEVN 333
            |:| :.:|    :|:.||:    |.:.|..:...|.:|:|.....:.....|.|::|...:|:|.
Zfish    89 RNIRINQW----TNVSSVNWILELSHVLIPEAQVGTYTLRAYIGDRIISQSFDVKQYVLPKFDVT 149

  Fly   334 VTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNL 398
            |..|..:...|..:.......:|.|.||.|.:.:            :|..:.:...:.|...:..
Zfish   150 VNAPQTYSVADVGLKVEACGKYTFGQPVPGQVLV------------EVCRQPFTFAQDPKVTSIC 202

  Fly   399 YNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDS 463
            ..:..:.||
Zfish   203 LIKSTKTNN-------------------------------------------------------- 211

  Fly   464 SYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATVGEKFYDEIISGYSVA 528
                 :|....||....:|..:|:            .||.||.| :...:.|:....::|..:..
Zfish   212 -----TGCASLTLSTSSFFGTSFE------------SNLQNSFV-VNVNLTEEGTGVVMSKSTTV 258

  Fly   529 RVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDW 593
            .:.....:|.|: |.|:.:.........::|...:|:||:...:.  |::.|           .|
Zfish   259 SITFEVGKVTFV-DLPKFYNYGSTVNGKISVSDFNGNPINSKAVY--LLDSS-----------IW 309

  Fly   594 PAQRL-PMSQQSDGIWEVKIDIRN----DLNL--DDRPQARDFLNG----VQNMRLQANFVDPRG 647
            |.:.| .::...:|..:..:|..:    ||||  ...||:....|.    ..:..:|.:..||..
Zfish   310 PNKLLFNLTTNKNGFAKFSLDTTSFPQADLNLVASATPQSYFSSNSPYFTTDSQVVQLSQTDPDT 374

  Fly   648 ERIQTELLLVSHYSPRNQHIKVTTSTEKPVVGEYIIFHIRTNFYLEEFNYLIMSKGVILVND--- 709
            ... ::|.:|....|.......:.:.:...|||       |..|..:..|::||:|||:::.
Zfish   375 PTF-SDLSIVKLEQPLKCGTTYSVTVKYLFVGE-------TGDYSADIIYMVMSRGVIVLHGFKT 431

  Fly   710 -----RETITEGIKTIAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNR 769
                 ..|:|:|..|..:.:.::||||..|:|:.:.....||..|..|.......|..::..:..
Zfish   432 VQARASNTLTKGTVTFDLSILAKMAPVVQILVYSVLPSQTVVTGSALFDTEKCFANQVSLQFSPA 496

  Fly   770 KARTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTNGTYKHIWYSH 834
            .|..||...:.:..:.||..|||.||.:...||:|..|: |:.:..|  ...|:...|.   :..
Zfish   497 SAVPGEGSILTVSAQAGSLCGLSAIDQSVLIMQSGGRLS-AEAVFNM--LPLQSLSDYP---FGA 555

  Fly   835 EGNPDELVYFPASSFGVD-ANRTFEYSGLIVFTDGYVPRRQDTCNRTLGFGECLSGRCYRLEKQC 898
            |...:.|...|..:...| |..||:..|:.:.|:  :|.|:..|   |.|.:.|..|.:.
Zfish   556 EDQQNCLNVRPRRAVPTDQAYNTFKSVGIKIATN--LPVREPEC---LKFKDLLYYRNFH----- 610

  Fly   899 DGLFDCDDGTDEINCHA-----------RNDTELLNYRKYRFNRVLRHYENVWLWKDVNIGPHGR 952
             |:|...:....::..|           ...:.::..|.|        :...|:|:...:|..|.
Zfish   611 -GVFPLREVAFAVSGKAPAPLAMAEMAGTGGSSVVTLRTY--------FPETWIWQLSLVGDSGS 666

  Fly   953 YIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVF 1017
            ....:.|||....|...||.:| |.|||:...|| ....||||:.:.:|.:..:||...:..|||
Zfish   667 TSVPLTVPDTITTWDTEAFCLS-SNGFGLAPPAL-LTSFQPFFLELTLPYSIIRGEAFELVATVF 729

  Fly  1018 NYMITPIEAIVVLHDSPDYKFVHV-EEDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPV---V 1078
            ||::..|:..|....|.:|....: ::.....|.|.|.:.   ::.:.....||..|.:..   .
Zfish   730 NYLLQCIKIQVTPTPSSNYTLTPINDQSSSTLSTNWRKTI---KWALTASVIGTVNVTISAEASP 791

  Fly  1079 PQRL-GNVDVTLHVATLLGTDTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQTPE 1142
            .|.| |:.|||  |.:....|.:||:|.|.::|:.:...:|.|  |..:..:|. ..|.:|
Zfish   792 SQELCGDQDVT--VPSRGRIDIVTRSLRVLAEGVERTFTRSWL--LCPKGSMLS-ESVKIT---- 847

  Fly  1143 IPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFSFAANLYTIMYMR 1207
            :|..|    :.||....:||:||::|....    |.::||.:|...||||....|.|:|.:.|:.
Zfish   848 LPTNV----IQGSASCSVSVIGDIMGRALN----NLANLLQMPSGCGEQNMIILAPNVYILRYLT 904

  Fly  1208 LINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEASFYE 1272
            :..|....:...|..::..|||.||::...|||||.|..|    .|:.|||::.:|.|..|
Zfish   905 VTAQLTPAIRDTATGYLLTGYQGQLNYRHSDGSFSTFGYD----PSNTWLTAFVMRTFGLA---- 961

  Fly  1273 WENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRKMNRTNFDKNITLTSHVLITLATVKDI 1337
             .:|.:||..::.....||:..|...|.|.:...|....| :.....|:|:|.::   :|::.:|
Zfish   962 -RSFTYIDPNVLAGAKNWLISTQGSDGCFVQQGTLYHNDM-KGGVGDNVTMTGYI---VASLLEI 1021

  Fly  1338 SGTLGSRVALATQRALAYIERNMDFLR----HQAQPFDVAITAYALQLC-NSPIAEEVFAILRRQ 1397
            ...:...|          |.:.:.|||    :....:..|:.|:...|. .:....::.:.||..
Zfish  1022 GVPVTDPV----------ITKALSFLRPLVGNLGNTYVTALLAHTFSLAGETNTRAQLLSSLRNT 1076

  Fly  1398 ARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREF------F 1456
            |.:.|..::|....                     ..|:|.:|.:||.||..:..:..      :
Zfish  1077 AISEGTTLHWSQTT---------------------SGDTLAVEISAYVLLAVLTVQPVTTANLGY 1120

  Fly  1457 VDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGGKTQTLYID 1521
            .:.||.|:.:|:...||::|||||..||:||..|..:: .....|.||.:::|...|......:.
Zfish  1121 ANRIVNWIVAQQNPYGGFSSTQDTVVALQALALYAAQA-FTPGGSSTVTVQSSVPAGDIFNFAVT 1184

  Fly  1522 DTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDIEKFQTKPPVPAFGLHTKAIFHGRN 1586
            ..|....|...:.:..||..|.|:|:..|.:|:...||:         |.|        :...|.
Zfish  1185 PNNRLLYQRNSLNNFPGTYSVVARGSACASVQVACFYNI---------PTP--------VMVART 1232

  Fly  1587 QSHISYVA--CQNW-IN---------QNESERSGMAVLDVAIPTGYWIQQQKLDTYVLS---NRV 1636
            .|.::.|:  ||.. :|         ......:.|.::|:.:.:|:     ..||.:|.   |..
Zfish  1233 LSVVAKVSGDCQAAPVNLMLTFTVKYNGRKPTTNMVLVDIKVLSGF-----TADTSLLGSPPNFA 1292

  Fly  1637 RNLRRARYLERKIVFYFDYLDHEDICVNFTIERWYPVANMSRYLP--VRIYDYY 1688
            ..::|.......::.|...:. :.:.|.|:|:....|| :....|  :.|||||
Zfish  1293 PLVQRVDSNGDHVLVYLQEVP-KGVPVTFSIQLTQTVA-VQNLKPAVINIYDYY 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	31/104 (30%)
		A2M_N_2	669..799	CDD:285005	36/137 (26%)
		LDLa	886..913	CDD:238060	4/26 (15%)
		A2M	940..1030	CDD:278630	31/89 (35%)
		ISOPREN_C2_like	1177..1490	CDD:298658	83/323 (26%)
		A2M_comp	1226..1492	CDD:284982	70/276 (25%)
		A2M_recep	1607..1695	CDD:284981	20/87 (23%)
si:dkey-46g23.2	XP_021327775.1	A2M_N	47..138	CDD:307790	28/94 (30%)
		A2M_N_2	380..528	CDD:311575	39/154 (25%)
		A2M	653..741	CDD:306673	30/89 (34%)
		A2M_2	871..1146	CDD:239227	79/322 (25%)
		A2M_recep	1265..1354	CDD:311553	20/87 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11188
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820