Protein Alignment Mcr and a2m3f

DIOPT Version :10

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: XP_068074598.2
• Gene: a2m3f / 793100
• ZFINID: ZDB-GENE-070705-476
• Length: 1457
• Species: Danio rerio
• Alignment Length: 1674
• Identity: 370/1674 - (22%)
• Similarity: 647/1674 - (38%)
• Gaps: 366/1674 - (21%)

  Fly   122 LESLHSREPT-----------YFIVASRMVRPGLIYQVSVSILQAQYPITVHASIACDGVQISGD 175
            ||:...|||.           :.:....::..|...::..|:|:.|..:|:..::.        |
Zfish    28 LEAPRPREPVVTADEQISGPLFLVTFPSLIESGSGAKLCASLLKPQGSLTITITLI--------D 84

  Fly   176 SKDVKEGIPETLLMR--------------IPPTSVTGSYKLRVEGFYQNVFGGLAF--LNETRLD 224
            .|:.     ||.|.|              .|..:......:||      |..|.:|  ..|.::.
Zfish    85 DKNT-----ETQLARQTTQRKLHRCFNFQAPLVNGDSVQTVRV------VVQGQSFKMTEERKVM 138

  Fly   225 FSQRSMTIFVQTDKPLYMQGETVRFRTIPITTELKGFDNPVDVYMLDPNRHI-LKRWLSRQSNLG 288
            |.......|:|||||||..|:||.||.:.::.:|...|...::.:|:..|:| :.:|    :|:.
Zfish   139 FRSYLPLTFIQTDKPLYNPGQTVNFRVVTMSDKLVPLDQMYNLVVLEDFRNIRINQW----TNVS 199

  Fly   289 SVS----LEYKLSDQPTFGEWTIRVIAQGQQEESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYG 349
            ||:    |.:.|..:...|.:|:|.....:.....|.|::|...:|:|.|..|..:...|..:..
Zfish   200 SVNWILELSHVLIPEAQVGTYTLRAYIGDRIISQSFDVKQYVLPKFDVTVNAPQTYSVADVGLKV 264

  Fly   350 RVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQV 414
            .....:|.|.||.|.:.:            :|..:.:...:.|...:...|:..:.||
Zfish   265 EACGKYTFGQPVPGQVLV------------EVCRQPFTFAQDPKVTSICLNKSTKTNN------- 310

  Fly   415 QYNVPGQLPQDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYL 479
                                                                  :|....||...
Zfish   311 ------------------------------------------------------TGCASLTLSTS 321

  Fly   480 RYFNGTFDFKWPLRELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSSLRVVFLGDSP 544
            .:|..:|:            .||.||.| :...:.|:....::|..:...:.....:|.|: |.|
Zfish   322 SFFGTSFE------------SNLQNSFV-VNVNLTEEGTGVVMSKSTTVSITFEVGKVTFV-DLP 372

  Fly   545 QVFKPAMPFTTYLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRL-PMSQQSDGIW 608
            :.:.........::|...:|:||....:.  |::.|           .||.:.| .::...:|..
Zfish   373 KFYNYGSTVNGKISVSDFNGNPIYSKAVY--LLDSS-----------IWPNKLLFNLTTNKNGFA 424

  Fly   609 EVKIDI----RNDLNL--DDRPQARDFLNG----VQNMRLQANFVDPRGERIQTELLLVSHYSPR 663
            :..:|.    :.||||  ...||:....|.    ..:..:|.:..||..... ::|.:|....|.
Zfish   425 KFSLDTTSFPKADLNLVASATPQSYFSSNSPYFTTDSQVVQLSQTDPDTPTF-SDLSIVKLEQPL 488

  Fly   664 NQHIKVTTSTEKPVVGEYIIFHIRTNFYLEEFNYLIMSKGVILVND--------RETITEGIKTI 720
            ......:.:.:...|||       |..|..:..|::||:|||:::.        ..|:|:|..|.
Zfish   489 KCGTTYSVTVKYLFVGE-------TGDYSADIIYMVMSRGVIVLHGFKTVQARASNTLTKGTVTF 546

  Fly   721 AVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEP 785
            .:.:.::|||:..|:|:.:.....||..|.:|.......|..::..:...|..||...:.:..:.
Zfish   547 DLSVLAKMAPIVQILVYSVLPSQTVVTGSASFDTEKCFSNQVSLQFSPATAVPGEGNILTVSAQA 611

  Fly   786 GSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTNGTYKHIWYSHEGNPDELVYFPASSFG 850
            ||..|||.||.:...||:|..|:...:...:   ..|:...|.   |..|...:.|...|..:..
Zfish   612 GSLCGLSAIDQSVLIMQSGGRLSAEGVFNML---PLQSLSDYP---YGAEDQQNCLNVRPRRAVP 670

  Fly   851 VD-ANRTFEYSGLIVFTDGYVPRRQDTCNRTLGFGECLSGRCYRLEKQCDGLFDCDDGTDEINCH 914
            .| |..||:..|:.:.|:  :|.|:..|   |.|.:.|..|.:.      |:|...:....::..
Zfish   671 TDQAYNTFKSVGMKIATN--LPVREPEC---LKFKDLLYYRNFH------GVFPLREVAFAVSGK 724

  Fly   915 ARNDTEL----------LNYRKYRFNRVLRHYENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMVS 969
            |.....:          :..|.|        :...|:|:...:|..|.....:.|||....|...
Zfish   725 APAPLAMAEMAGTGGSSVTIRTY--------FPETWIWQLSLVGDSGSTSVPLTVPDTITTWDTE 781

  Fly   970 AFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSP 1034
            ||.:| |.|||:...|| ....||||:.:.:|.:..:||...:..|||||::..::..|....|.
Zfish   782 AFCLS-SNGFGLAPPAL-LTSFQPFFLELTLPYSIIRGEAFELVATVFNYLLQCLKIQVTPTPSS 844

  Fly  1035 DYKFVHV-EEDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPV---VPQRL-GNVDVTLHVATL 1094
            :|....: ::.....|.|.|.:.   ::.:.....||..|.:..   ..|.| |:.|||  |::.
Zfish   845 NYTLTPINDQSSSTLSTNWRKTI---KWALTASVIGTVNVTISAEASPSQELCGDQDVT--VSSR 904

  Fly  1095 LGTDTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKAR 1159
            ...|.:||:|.|.::|:.:...:|.|  |..:..:|. ..|.:|    :|..|    :.||....
Zfish   905 GRIDIVTRSLRVLAEGVERTFTRSWL--LCPKGSILS-ESVKIT----LPTNV----IQGSASCS 958

  Fly  1160 ISVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHM 1224
            :||:||::|....    |.::||.:|...||||....|.|:|.:.|:.:..|....::..|...:
Zfish   959 VSVIGDIMGRALN----NLANLLQMPSGCGEQNMIILAPNVYILRYLTVTAQLTPAIQDTATSSL 1019

  Fly  1225 NIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMR 1289
            ..|||.:|::...|||||.|..|    .|:.|||::.:|.|..|     .:|.:||..:::....
Zfish  1020 LTGYQGELNYRHSDGSFSTFGYD----PSNTWLTAFVMRTFGLA-----RSFTYIDPNVLKGAKD 1075

  Fly  1290 WLLQHQTPQGSFFEVTWLPDRKMNRTNFDKNITLTSHVLITLATV----------------KDIS 1338
            ||:..|...|.|.:...|....| :.....|:|:|.:::.:|..:                :.:.
Zfish  1076 WLISTQGSDGCFVQQGTLYHNDM-KGGVGDNVTMTGYIVASLLEIGVPVTDPVITKALSFLRPLV 1139

  Fly  1339 GTLGSRVALATQRALAYIERNMDFLRHQAQPFDVA-ITAYALQLCNSPIAEEVFAILRRQARTIG 1402
            |.||:....|   .|||             .|.:| .|:...||.||         ||..|.:.|
Zfish  1140 GNLGNTYVTA---LLAY-------------TFSLAGETSTRAQLLNS---------LRNTAISEG 1179

  Fly  1403 DFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREF------FVDPIV 1461
            ..::|....                     ..|:|.:|.:||.||..:..:..      :.:.||
Zfish  1180 TTLHWSQTT---------------------SGDTLAVEISAYVLLAVLTVQPVTTANLGYANRIV 1223

  Fly  1462 RWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGGKTQTLYIDDTNLA 1526
            .|:.:|:...||::|||||..||:||..|..:: .....|.||.:::|...|......:...|..
Zfish  1224 NWIVAQQNPYGGFSSTQDTVVALQALALYAAQA-FTPGGSSTVTVQSSVPAGDNFNFAVTPNNRL 1287

  Fly  1527 KLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDIEKFQTKPPVPAFGLHTKAIFHGRNQSHIS 1591
            ..|...:.:..||..|.|:|:..|.:|:...||:         |.|        :...|..|.::
Zfish  1288 LYQRNSLNNFPGTYNVVARGSACASVQVACFYNI---------PTP--------VMVARTLSVVA 1335

  Fly  1592 YVA--CQNW-IN---------QNESERSGMAVLDVAIPTGYWIQQQKLDTYVLS---NRVRNLRR 1641
            .|:  ||.. :|         ......:.|.::|:.:.:|:     ..||.:|.   |....::|
Zfish  1336 KVSGDCQAAPVNLMLTFTVKYTGRKPTTNMVLVDIKVLSGF-----TADTSLLGSPPNFAPLVQR 1395

  Fly  1642 ARYLERKIVFYFDYLDHEDICVNFTIE--RWYPVANMSRYLPVRIYDYY 1688
            .......::.|...:. :.:.|.|:|:  |...|.|:...: :.|||||
Zfish  1396 VDSNGDHVLVYLQEVP-KGVPVTFSIQLTRAVAVQNLKPAV-INIYDYY 1442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	YfaS	<226..1575	CDD:441940	320/1411 (23%)
		A2M_BRD	667..801	CDD:462235	35/141 (25%)
		A2M	939..1030	CDD:459711	30/90 (33%)
		TED_complement	1160..1490	CDD:462227	92/352 (26%)
		A2M_recep	1605..1699	CDD:462226	20/89 (22%)
a2m3f	XP_068074598.2	None