DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mcr and zgc:171445

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:NP_001107101.1 Gene:zgc:171445 / 793035 ZFINID:ZDB-GENE-080205-2 Length:1459 Species:Danio rerio


Alignment Length:1721 Identity:375/1721 - (21%)
Similarity:648/1721 - (37%) Gaps:440/1721 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   130 PTYFIVASRMVRPGLIYQVSVSILQAQYPITVHASIACDGVQISGDSKDVKEGIPETL----LMR 190
            |.:.:....::..|...::..|:|:.|..:|:..::..|.   |.:::.|::.....|    ..:
Zfish    47 PLFLVTFPSLIESGSGAKLCASLLKPQGSLTITITLIDDK---SAETRLVRQTTQRKLHRCFNFQ 108

  Fly   191 IPPTSVTGSYKLRVEGFYQNVFGGLAF--LNETRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIP 253
            .|..:......:||      |..|.:|  ..|.::.|.......|:|||||||..|:||.||.:.
Zfish   109 APLVNGDSVQTVRV------VVQGQSFKMTEERKVVFRSYLPLTFIQTDKPLYNPGQTVNFRVVT 167

  Fly   254 ITTELKGFDNPVDVYMLDPNRHI-LKRWLSRQSNLGSVS----LEYKLSDQPTFGEWTIRVIAQG 313
            ::.:|...|...::.:|:..|:| :.:|    :|:.||:    |.:.|..:...|.:|:|.....
Zfish   168 MSDKLVPLDQMYNLVVLEDFRNIRINQW----TNVSSVNWILELSHVLIPEAQVGTYTLRAYIGD 228

  Fly   314 QQEESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFS 378
            :.....|.|::|...:|:|.|.....:...|..:.......:|.|.||.|.:.::...:|:.:. 
Zfish   229 RIISQSFDVKQYVLPKFDVTVNTLQIYSVADAGLKVEACGKYTFGQPVPGQVLVQVCRQPLAFI- 292

  Fly   379 NQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQYVVER 443
                       :.|...:...|:..|.||                                    
Zfish   293 -----------QDPKVTSICLNKSTRTNN------------------------------------ 310

  Fly   444 HYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVL 508
                                     :|....||....:|..:|:            .||.|| .:
Zfish   311 -------------------------TGCASLTLGTSSFFGTSFE------------SNLQNS-FI 337

  Fly   509 ITATVGEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPIDPNLLR 573
            :...:.|:....::|..:...:.....:|.|: |.|:.              |:.||.::     
Zfish   338 VNVNLTEEGTGIVMSKSTTVSITFEVGKVTFV-DLPKF--------------YNYGSTVN----- 382

  Fly   574 QGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKI--DIRNDLN------LDDR--PQARD 628
             |.:.||.|    ||.    |.....:......||..|:  ::..:.|      ||..  |||. 
Zfish   383 -GKISVSDF----NGN----PIYNKAVYLLDSSIWPNKVLFNLTTNYNGFAKFSLDTTSFPQAD- 437

  Fly   629 FLNGVQNMRLQANFVDPRGERIQTELLLVSHYSP----RNQHIKVT-TSTEKPVVGEYIIFHI-- 686
             ||.|.:...|:.|               |:|||    .:|.:::: |..:.|...:..|..:  
Zfish   438 -LNLVASATPQSYF---------------SYYSPYFTTDSQVVQLSQTDPDTPTFSDLSIVKLEQ 486

  Fly   687 ------------------RTNFYLEEFNYLIMSKGVILVND--------RETITEGIKTIAVVLS 725
                              .|..|..:..|::||:|||:::.        ..|:|:|..|..:.:.
Zfish   487 PLKCGTTYSVTVKYLFVGETGDYSADIIYMVMSRGVIVLHGFKTVQARASNTLTKGTVTFDLSIL 551

  Fly   726 SEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEPGSYVG 790
            :.|||:..|:|:.:.....||..|.:|.......|..::..:...|..||...:.:..:.||..|
Zfish   552 ANMAPMVQILVYSVLPSQTVVTGSASFDTEKCFSNQVSLQFSPATAVPGEGSILTVSAQAGSLCG 616

  Fly   791 LSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTNGTYKHIWYSHEGNPDELVYFPASSFGVD-AN 854
            ||.||.:...||:|..|: |:.:..|  ...|:...|.   |..|...|.|...|..:...| |.
Zfish   617 LSAIDQSVLIMQSGGRLS-AEAVFNM--LPLQSLSDYP---YGAEDQQDCLNVRPRRAVPTDQAY 675

  Fly   855 RTFEYSGLIVFTDGYVPRRQDTCNRTLGFGECLSGRCYRLEKQCDGLFDCDDGTDEINCHARNDT 919
            .||:..|:.:.|:  :|.|:.         |||..:                             
Zfish   676 NTFKSVGMKIATN--LPVREP---------ECLKFK----------------------------- 700

  Fly   920 ELLNYRKYRFNRVL-----------------------------------RHYENVWLWKDVNIGP 949
            :||.||  .|:||:                                   .::...|:|:...:|.
Zfish   701 DLLYYR--NFHRVIPFRGTGFAMAEMAPAPLAMAEIGGTRGSSVDVTIRTYFPETWIWQLATVGD 763

  Fly   950 HGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRV 1014
            .|.....:.|||....|...||.:| |.|||:....| ....||||:.:.:|.:..:||...:..
Zfish   764 SGSTSVPLTVPDTTTTWDTEAFCLS-SNGFGLAPPVL-LTSFQPFFLELTLPYSIIRGEAFELVA 826

  Fly  1015 TVFNYMITPIEAIVVLHDSPDYKFVHV-EEDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPV- 1077
            |||||::..|:..|....|.:|....: ::.....|.|.|.:.   ::.:.....||..|.:.. 
Zfish   827 TVFNYLLQCIKIQVTPTPSSNYTLTPINDQSSSTLSTNWRKTI---KWALTASVIGTVNVTISAE 888

  Fly  1078 --VPQRL-GNVDVTLHVATLLGTDTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQ 1139
              ..|.| |:.|||  |.:....|.:||:|.|.::|:.:...:|.|  |..:..:|. ..|.:| 
Zfish   889 ASPSQELCGDQDVT--VLSRGRIDIVTRSLRVLAEGVERTFTRSWL--LCPKGSMLS-ESVKIT- 947

  Fly  1140 TPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFSFAANLYTIM 1204
               :|..|    :.||....:||:||::|....    |.::||.:|...||||....|.|:|.:.
Zfish   948 ---LPKSV----IQGSASCSVSVIGDIMGRALN----NLANLLQMPSSCGEQNMIILAPNVYILR 1001

  Fly  1205 YMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEAS 1269
            |:.:..|....::..|..::..|||.:|::...|||||.|..|.:|:    |||::.:|.|..| 
Zfish  1002 YLTVTAQLTPAIQDTATSYLLTGYQGELNYRHSDGSFSTFGYDASNT----WLTAFVMRTFGLA- 1061

  Fly  1270 FYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRKMNRTNFDKNITLTSHVLITLATV 1334
                .:|.:||..:::....||:..|...|.|.:...|....| :.....|:|:|.:::.:|   
Zfish  1062 ----RSFTYIDPNVLKGAKDWLIGTQGSDGCFVQQGTLYHNDM-KGGVGDNVTMTGYIVASL--- 1118

  Fly  1335 KDISGTLGSRVALATQRALAYIERNMDFLR----HQAQPFDVAITAYALQLC-NSPIAEEVFAIL 1394
                      :.:........|.:.:.|||    :....:..|:.||...|. .:....::|:.|
Zfish  1119 ----------LEIGVPATDPVITKALSFLRPLVGNLGNAYVTALLAYTFSLAGETSTRAQLFSSL 1173

  Fly  1395 RRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREFFVDP 1459
            |..|.:.|..::|....                     ..|:|.:|.:||.||.     :..|.|
Zfish  1174 RNTAISEGTTLHWSQTT---------------------SGDTLAVEISAYVLLA-----DLTVQP 1212

  Fly  1460 -----------IVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGG 1513
                       ||.|:.:|:...||::|||||..||:||..|..:: .....|.||.:::|...|
Zfish  1213 VTTANLGYANRIVSWIVAQQNPYGGFSSTQDTVVALQALALYAAQA-FTPGGSSTVTVQSSVPAG 1276

  Fly  1514 KTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDIEKFQTKPPVPAFGLHT 1578
            ......:...|....|...:.:..||..|.|:|:..|.:|:...||:         |.|.....|
Zfish  1277 DVFNFAVTPNNRLLYQRNSLNNFPGTYSVVARGSACASVQVACFYNI---------PTPVTVART 1332

  Fly  1579 KAIFHGRNQSHISYVA-----CQNW-IN---------QNESERSGMAVLDVAIPTGYWIQQQKLD 1628
                       :|.||     ||.. :|         ......:.|.::|:.:.:|:     ..|
Zfish  1333 -----------LSVVAKVTGDCQAAPVNLMLTFTVKYNGRKPATNMVLVDIKVLSGF-----TAD 1381

  Fly  1629 TYVLS---NRVRNLRRARYLERKIVFYFDYLDHEDICVNFTIERWYPVA--NMSRYLPVRIYDYY 1688
            |.:|.   |....::|.......::.|...:. :.:.|.|:|:....||  |:...: :.|||||
Zfish  1382 TSLLGSPPNFAPLVQRVDSNGDHVLVYLQEVP-KGVPVTFSIQLTQTVAVQNLKPAV-INIYDYY 1444

  Fly  1689 -APERFNESIFDALPTYLLNICEVCGSSQCP 1718
             ..::|.       .||         .|.||
Zfish  1445 QRSDKFE-------TTY---------KSPCP 1459

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 31/104 (30%)
A2M_N_2 669..799 CDD:285005 35/158 (22%)
LDLa 886..913 CDD:238060 2/26 (8%)
A2M 940..1030 CDD:278630 30/89 (34%)
ISOPREN_C2_like 1177..1490 CDD:298658 84/328 (26%)
A2M_comp 1226..1492 CDD:284982 71/281 (25%)
A2M_recep 1607..1695 CDD:284981 21/93 (23%)
zgc:171445NP_001107101.1 A2M_N 146..237 CDD:280081 28/94 (30%)
YfaS <147..>1080 CDD:225248 257/1147 (22%)
A2M_N_2 481..625 CDD:285005 33/143 (23%)
A2M 753..841 CDD:278630 29/89 (33%)
A2M_2 971..1246 CDD:239227 80/327 (24%)
A2M_comp 1023..1246 CDD:284982 66/271 (24%)
A2M_recep 1365..1454 CDD:284981 21/102 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 54 1.000 Domainoid score I11188
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.820

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