Protein Alignment Mcr and C5

DIOPT Version :10

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: NP_001304092.1
• Gene: C5 / 727
• HGNCID: 1331
• Length: 1682
• Species: Homo sapiens
• Alignment Length: 1769
• Identity: 381/1769 - (21%)
• Similarity: 692/1769 - (39%)
• Gaps: 449/1769 - (25%)

  Fly   132 YFIVASRMVRPG----LIYQV---------SVSILQAQYPITVHASIACDGVQISGDSKDVKEGI 183
            |.|.|.::.|.|    ::.||         ::||  ..|| ....|.:...|.:|.::|     .
Human    29 YVISAPKIFRVGASENIVIQVYGYTEAFDATISI--KSYP-DKKFSYSSGHVHLSSENK-----F 85

  Fly   184 PETLLMRIPPTSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQGETVR 248
            ..:.::.|.|..:.|... .|...|..|. ...|....|:..:..:..:|:.||||:|...::|:
Human    86 QNSAILTIQPKQLPGGQN-PVSYVYLEVV-SKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVK 148

  Fly   249 FRTIPITTELKGFDNPVDVYMLDPNRHILKRWLSRQSNLGSVSL-EYKLSDQPTFGEWTIRVIAQ 312
            .|...:..:||.......:..:||....:. .:....::|.:|. ::|:...|.:|.|||:  |:
Human   149 VRVYSLNDDLKPAKRETVLTFIDPEGSEVD-MVEEIDHIGIISFPDFKIPSNPRYGMWTIK--AK 210

  Fly   313 GQQEES-----HFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIR 372
            .:::.|     :|.|:||....|.|::. |.|     .||..:...||        .:||||.
Human   211 YKEDFSTTGTAYFEVKEYVLPHFSVSIE-PEY-----NFIGYKNFKNF--------EITIKAR-- 259

  Fly   373 PIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRN 437
               ||.|:|:.|                                          ||:
Human   260 ---YFYNKVVTE------------------------------------------ADV-------- 271

  Fly   438 QYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNG----TFDFKWPLRELELL 498
             |:.           |.:|: :.:|...|......:.|:    ..||    |||.:..::||...
Human   272 -YIT-----------FGIRE-DLKDDQKEMMQTAMQNTM----LINGIAQVTFDSETAVKELSYY 319

  Fly   499 -VPNLANSEVLITATVGEK---FYDE--------IISGYSVARVYNSSLRVVFLGDSPQVFKPAM 551
             :.:|.|..:.|..||.|.   |.:|        ::|.|.:..|           .:|...||.:
Human   320 SLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLV-----------ATPLFLKPGI 373

  Fly   552 PFTTYLAVEYHD-------GSP-------IDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQ 602
            |:.  :.|:..|       |.|       ||.|      .|.|....|::..|.|.......::.
Human   374 PYP--IKVQVKDSLDQLVGGVPVTLNAQTIDVN------QETSDLDPSKSVTRVDDGVASFVLNL 430

  Fly   603 QSDGIWEVKIDIRNDL-NLDDRPQARDFLNGVQNMRLQAN--FVDPRGERIQTELLLVSHYSPRN 664
            .| |:..::.:::.|. :|.:..|||:....:....|..:  ::|.....   :.|||      .
Human   431 PS-GVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNH---KALLV------G 485

  Fly   665 QHIKVTTSTEKPVVGEYIIFHIRTNFYLEEFNYLIMSKG-VILVNDRETITE-GIKTIAVVLSSE 727
            :|:.:..:.:.|.:.:           :..:||||:||| :|....||..:: ..::|.:.::..
Human   486 EHLNIIVTPKSPYIDK-----------ITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQN 539

  Fly   728 MAPVATIVVWKI---NQQGQVVADSLTFPVNGISRNNFTVYIN-NRKART-GEKVEVAIFGEPGS 787
            |.|.:.::|:.|   .|..::|:||:...:.....|...|::: :..|.: |:.|.:.:.....|
Human   540 MVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDS 604

  Fly   788 YVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTN-GTYKHIWYSHEGNPDELVYFPASSFGV 851
            :|.|:.:|||.|.:|.|.:    |.:.::..|.|::: |.                   .:..|:
Human   605 WVALAAVDSAVYGVQRGAK----KPLERVFQFLEKSDLGC-------------------GAGGGL 646

  Fly   852 DANRTFEYSGLIVFTDGYVPRRQDT---C------NRTL--GFGECLSGRCYRLEKQCDGLFDCD 905
            :....|..:||...|:......|:.   |      .|||  ...|..:...:.:.|:|     |.
Human   647 NNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKC-----CY 706

  Fly   906 DG----TDEINCHARND------------TEL----------LNYRKYRFNR------------- 931
            ||    .|| .|..|..            ||.          ::::..:..|
Human   707 DGACVNNDE-TCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPE 770

  Fly   932 VLRHYENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKAL---EYVGVQP 993
            :..::...||| :|::.|..:.: ...:||....|.:        :|.|:.|..:   :.|..:.
Human   771 IRSYFPESWLW-EVHLVPRRKQL-QFALPDSLTTWEI--------QGVGISNTGICVADTVKAKV 825

  Fly   994 F---FINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPRTS 1055
            |   |:.:.:|.:..:|||:.::.||:||..:.::..|        |...||  ||..|.:|
Human   826 FKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCV--------KMSAVE--GICTSESP--- 877

  Fly  1056 FGEHQFFIYLEAQGTT---------------VVYVPVVPQRLGNVDVTLHVATLLGTDTITRTLH 1105
                    .::.|||.               :|...|:|..:|..::...:.|..|.:.:.:||.
Human   878 --------VIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLR 934

  Fly  1106 VESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARI-SVVGDVVGP 1169
            |..:|:.:..:..|.||...       ::..:::..|.||::....|..:...|| ||.|.:||.
Human   935 VVPEGVKRESYSGVTLDPRG-------IYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGE 992

  Fly  1170 IFPTMPVNASSLLS---------LPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMN 1225
            |.       |::||         ||..|.|....|.....|...|:...|..|       .:|.:
Human   993 IL-------SAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWN-------IFHSD 1043

  Fly  1226 IGYQRQ-------------LSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEASFYEWENFI 1277
            ...::|             :|:...|.|:|:    |....:|.|||::.|||..:.:.|..:|
Human  1044 PLIEKQKLKKKLKEGMLSIMSYRNADYSYSV----WKGGSASTWLTAFALRVLGQVNKYVEQN-- 1102

  Fly  1278 WIDATIIEKNMRWLLQ-HQTPQGSFFEVTWLPDRKMNRT----NFDKNITLTSHVLITLATVKDI 1337
               ...|..::.||:: :|...|||.|.:.....|:..|    ..:.::.||:..:|.:....||
Human  1103 ---QNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDI 1164

  Fly  1338 SGTLGSRVALATQRALAYIERNMDFLRHQAQP----FDVAITAYALQLCNS--PIAEEVFAILRR 1396
            ...:....||.         :..:||.....|    |.:||:||||.|.:.  |....:.:.|:|
Human  1165 CPLVKIDTALI---------KADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKR 1220

  Fly  1397 QARTIGD---FMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREF-FV 1457
            :|...|:   :.:|.:        .|:::.    ..:|....:..:||||||||..:..::. :|
Human  1221 EALVKGNPPIYRFWKD--------NLQHKD----SSVPNTGTARMVETTAYALLTSLNLKDINYV 1273

  Fly  1458 DPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVR-SRLREVSSLTVEIEASSQGGKTQTLYID 1521
            :|:::||:.::...||:.|||||..|::.|.||::. .:||  .|:.:::....:|........|
Human  1274 NPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLR--LSMDIDVSYKHKGALHNYKMTD 1336

  Fly  1522 DTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDIEKFQTKPPVPAFGL--HTKAI--F 1582
            ...|.:...:.:.|.    .:.:.|.|..:..:||  ...:.|..|...|.:|.|  .|:.|  .
Human  1337 KNFLGRPVEVLLNDD----LIVSTGFGSGLATVHV--TTVVHKTSTSEEVCSFYLKIDTQDIEAS 1395

  Fly  1583 HGRNQSHISY---VACQNWINQNESERSGM--AVLDVAIPTGYWIQQQKLDTYVLSNRVRNL-RR 1641
            |.|...:..|   |||.::....|...||.  ||:|:::|||  |...:.|...|...|..| ..
Human  1396 HYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTG--ISANEEDLKALVEGVDQLFTD 1458

  Fly  1642 ARYLERKIVFYFDYLDHED-ICVNFTIERWYPVANMSRYLPV--RIYDYYAPERFNESIFDALPT 1703
            .:..:..::...:.:...| :||.|.|...:.|..:|   |.  .:|:|:.|::.....:.   |
Human  1459 YQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLS---PATFTVYEYHRPDKQCTMFYS---T 1517

  Fly  1704 YLLNICEVCGSSQC 1717
            ..:.|.:||..:.|
Human  1518 SNIKIQKVCEGAAC 1531

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	YfaS	<226..1575	CDD:441940	318/1505 (21%)
		A2M_BRD	667..801	CDD:462235	32/140 (23%)
		A2M	939..1030	CDD:459711	23/96 (24%)
		TED_complement	1160..1490	CDD:462227	92/367 (25%)
		A2M_recep	1605..1699	CDD:462226	24/99 (24%)
C5	NP_001304092.1	MG1	29..126	CDD:465508	23/106 (22%)
		MG2	132..225	CDD:426464	23/95 (24%)
		MG3	227..307	CDD:465509	29/165 (18%)
		MG4	360..463	CDD:465507	24/122 (20%)
		A2M_BRD	473..616	CDD:462235	36/162 (22%)
		ANATO	688..756	CDD:237984	12/73 (16%)
		A2M	778..865	CDD:459711	23/104 (22%)
		complement_C3_C4_C5	999..1306	CDD:239226	83/343 (24%)
		A2M_recep	1427..1516	CDD:462226	22/93 (24%)
		NTR_complement_C5	1533..1682	CDD:239637