DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcr and C5

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:NP_001304092.1 Gene:C5 / 727 HGNCID:1331 Length:1682 Species:Homo sapiens


Alignment Length:1769 Identity:381/1769 - (21%)
Similarity:692/1769 - (39%) Gaps:449/1769 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   132 YFIVASRMVRPG----LIYQV---------SVSILQAQYPITVHASIACDGVQISGDSKDVKEGI 183
            |.|.|.::.|.|    ::.||         ::||  ..|| ....|.:...|.:|.::|     .
Human    29 YVISAPKIFRVGASENIVIQVYGYTEAFDATISI--KSYP-DKKFSYSSGHVHLSSENK-----F 85

  Fly   184 PETLLMRIPPTSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQGETVR 248
            ..:.::.|.|..:.|... .|...|..|. ...|....|:..:..:..:|:.||||:|...::|:
Human    86 QNSAILTIQPKQLPGGQN-PVSYVYLEVV-SKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQSVK 148

  Fly   249 FRTIPITTELKGFDNPVDVYMLDPNRHILKRWLSRQSNLGSVSL-EYKLSDQPTFGEWTIRVIAQ 312
            .|...:..:||.......:..:||....:. .:....::|.:|. ::|:...|.:|.|||:  |:
Human   149 VRVYSLNDDLKPAKRETVLTFIDPEGSEVD-MVEEIDHIGIISFPDFKIPSNPRYGMWTIK--AK 210

  Fly   313 GQQEES-----HFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIR 372
            .:::.|     :|.|:||....|.|::. |.|     .||..:...||        .:||||.  
Human   211 YKEDFSTTGTAYFEVKEYVLPHFSVSIE-PEY-----NFIGYKNFKNF--------EITIKAR-- 259

  Fly   373 PIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRN 437
               ||.|:|:.|                                          ||:        
Human   260 ---YFYNKVVTE------------------------------------------ADV-------- 271

  Fly   438 QYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNG----TFDFKWPLRELELL 498
             |:.           |.:|: :.:|...|......:.|:    ..||    |||.:..::||...
Human   272 -YIT-----------FGIRE-DLKDDQKEMMQTAMQNTM----LINGIAQVTFDSETAVKELSYY 319

  Fly   499 -VPNLANSEVLITATVGEK---FYDE--------IISGYSVARVYNSSLRVVFLGDSPQVFKPAM 551
             :.:|.|..:.|..||.|.   |.:|        ::|.|.:..|           .:|...||.:
Human   320 SLEDLNNKYLYIAVTVIESTGGFSEEAEIPGIKYVLSPYKLNLV-----------ATPLFLKPGI 373

  Fly   552 PFTTYLAVEYHD-------GSP-------IDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQ 602
            |:.  :.|:..|       |.|       ||.|      .|.|....|::..|.|.......::.
Human   374 PYP--IKVQVKDSLDQLVGGVPVTLNAQTIDVN------QETSDLDPSKSVTRVDDGVASFVLNL 430

  Fly   603 QSDGIWEVKIDIRNDL-NLDDRPQARDFLNGVQNMRLQAN--FVDPRGERIQTELLLVSHYSPRN 664
            .| |:..::.:::.|. :|.:..|||:....:....|..:  ::|.....   :.|||      .
Human   431 PS-GVTVLEFNVKTDAPDLPEENQAREGYRAIAYSSLSQSYLYIDWTDNH---KALLV------G 485

  Fly   665 QHIKVTTSTEKPVVGEYIIFHIRTNFYLEEFNYLIMSKG-VILVNDRETITE-GIKTIAVVLSSE 727
            :|:.:..:.:.|.:.:           :..:||||:||| :|....||..:: ..::|.:.::..
Human   486 EHLNIIVTPKSPYIDK-----------ITHYNYLILSKGKIIHFGTREKFSDASYQSINIPVTQN 539

  Fly   728 MAPVATIVVWKI---NQQGQVVADSLTFPVNGISRNNFTVYIN-NRKART-GEKVEVAIFGEPGS 787
            |.|.:.::|:.|   .|..::|:||:...:.....|...|::: :..|.: |:.|.:.:.....|
Human   540 MVPSSRLLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDADAYSPGQTVSLNMATGMDS 604

  Fly   788 YVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTN-GTYKHIWYSHEGNPDELVYFPASSFGV 851
            :|.|:.:|||.|.:|.|.:    |.:.::..|.|::: |.                   .:..|:
Human   605 WVALAAVDSAVYGVQRGAK----KPLERVFQFLEKSDLGC-------------------GAGGGL 646

  Fly   852 DANRTFEYSGLIVFTDGYVPRRQDT---C------NRTL--GFGECLSGRCYRLEKQCDGLFDCD 905
            :....|..:||...|:......|:.   |      .|||  ...|..:...:.:.|:|     |.
Human   647 NNANVFHLAGLTFLTNANADDSQENDEPCKEILRPRRTLQKKIEEIAAKYKHSVVKKC-----CY 706

  Fly   906 DG----TDEINCHARND------------TEL----------LNYRKYRFNR------------- 931
            ||    .|| .|..|..            ||.          ::::..:..|             
Human   707 DGACVNNDE-TCEQRAARISLGPRCIKAFTECCVVASQLRANISHKDMQLGRLHMKTLLPVSKPE 770

  Fly   932 VLRHYENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKAL---EYVGVQP 993
            :..::...||| :|::.|..:.: ...:||....|.:        :|.|:.|..:   :.|..:.
Human   771 IRSYFPESWLW-EVHLVPRRKQL-QFALPDSLTTWEI--------QGVGISNTGICVADTVKAKV 825

  Fly   994 F---FINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPRTS 1055
            |   |:.:.:|.:..:|||:.::.||:||..:.::..|        |...||  ||..|.:|   
Human   826 FKDVFLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCV--------KMSAVE--GICTSESP--- 877

  Fly  1056 FGEHQFFIYLEAQGTT---------------VVYVPVVPQRLGNVDVTLHVATLLGTDTITRTLH 1105
                    .::.|||.               :|...|:|..:|..::...:.|..|.:.:.:||.
Human   878 --------VIDHQGTKSSKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSLETWFGKEILVKTLR 934

  Fly  1106 VESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARI-SVVGDVVGP 1169
            |..:|:.:..:..|.||...       ::..:::..|.||::....|..:...|| ||.|.:||.
Human   935 VVPEGVKRESYSGVTLDPRG-------IYGTISRRKEFPYRIPLDLVPKTEIKRILSVKGLLVGE 992

  Fly  1170 IFPTMPVNASSLLS---------LPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMN 1225
            |.       |::||         ||..|.|....|.....|...|:...|..|       .:|.:
Human   993 IL-------SAVLSQEGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWN-------IFHSD 1043

  Fly  1226 IGYQRQ-------------LSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEASFYEWENFI 1277
            ...::|             :|:...|.|:|:    |....:|.|||::.|||..:.:.|..:|  
Human  1044 PLIEKQKLKKKLKEGMLSIMSYRNADYSYSV----WKGGSASTWLTAFALRVLGQVNKYVEQN-- 1102

  Fly  1278 WIDATIIEKNMRWLLQ-HQTPQGSFFEVTWLPDRKMNRT----NFDKNITLTSHVLITLATVKDI 1337
               ...|..::.||:: :|...|||.|.:.....|:..|    ..:.::.||:..:|.:....||
Human  1103 ---QNSICNSLLWLVENYQLDNGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRKAFDI 1164

  Fly  1338 SGTLGSRVALATQRALAYIERNMDFLRHQAQP----FDVAITAYALQLCNS--PIAEEVFAILRR 1396
            ...:....||.         :..:||.....|    |.:||:||||.|.:.  |....:.:.|:|
Human  1165 CPLVKIDTALI---------KADNFLLENTLPAQSTFTLAISAYALSLGDKTHPQFRSIVSALKR 1220

  Fly  1397 QARTIGD---FMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREF-FV 1457
            :|...|:   :.:|.:        .|:::.    ..:|....:..:||||||||..:..::. :|
Human  1221 EALVKGNPPIYRFWKD--------NLQHKD----SSVPNTGTARMVETTAYALLTSLNLKDINYV 1273

  Fly  1458 DPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVR-SRLREVSSLTVEIEASSQGGKTQTLYID 1521
            :|:::||:.::...||:.|||||..|::.|.||::. .:||  .|:.:::....:|........|
Human  1274 NPVIKWLSEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLR--LSMDIDVSYKHKGALHNYKMTD 1336

  Fly  1522 DTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDIEKFQTKPPVPAFGL--HTKAI--F 1582
            ...|.:...:.:.|.    .:.:.|.|..:..:||  ...:.|..|...|.:|.|  .|:.|  .
Human  1337 KNFLGRPVEVLLNDD----LIVSTGFGSGLATVHV--TTVVHKTSTSEEVCSFYLKIDTQDIEAS 1395

  Fly  1583 HGRNQSHISY---VACQNWINQNESERSGM--AVLDVAIPTGYWIQQQKLDTYVLSNRVRNL-RR 1641
            |.|...:..|   |||.::....|...||.  ||:|:::|||  |...:.|...|...|..| ..
Human  1396 HYRGYGNSDYKRIVACASYKPSREESSSGSSHAVMDISLPTG--ISANEEDLKALVEGVDQLFTD 1458

  Fly  1642 ARYLERKIVFYFDYLDHED-ICVNFTIERWYPVANMSRYLPV--RIYDYYAPERFNESIFDALPT 1703
            .:..:..::...:.:...| :||.|.|...:.|..:|   |.  .:|:|:.|::.....:.   |
Human  1459 YQIKDGHVILQLNSIPSSDFLCVRFRIFELFEVGFLS---PATFTVYEYHRPDKQCTMFYS---T 1517

  Fly  1704 YLLNICEVCGSSQC 1717
            ..:.|.:||..:.|
Human  1518 SNIKIQKVCEGAAC 1531

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 27/105 (26%)
A2M_N_2 669..799 CDD:285005 31/136 (23%)
LDLa 886..913 CDD:238060 7/30 (23%)
A2M 940..1030 CDD:278630 23/95 (24%)
ISOPREN_C2_like 1177..1490 CDD:298658 85/349 (24%)
A2M_comp 1226..1492 CDD:284982 74/293 (25%)
A2M_recep 1607..1695 CDD:284981 24/93 (26%)
C5NP_001304092.1 A2M_N 132..225 CDD:280081 23/95 (24%)
A2M_N_2 478..616 CDD:285005 35/157 (22%)
ANATO 688..756 CDD:237984 12/73 (16%)
A2M 778..865 CDD:278630 23/104 (22%)
complement_C3_C4_C5 999..1306 CDD:239226 83/343 (24%)
A2M_comp 1057..1307 CDD:284982 72/279 (26%)
A2M_recep 1427..1515 CDD:284981 22/92 (24%)
NTR_complement_C5 1533..1682 CDD:239637
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
54.880

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