DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcr and C4B

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:NP_001002029.3 Gene:C4B / 721 HGNCID:1324 Length:1744 Species:Homo sapiens


Alignment Length:1860 Identity:408/1860 - (21%)
Similarity:667/1860 - (35%) Gaps:553/1860 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 GLIYQVSVSILQAQ-------YPITVHASIACD-GVQISGDSKDVKEG--IPETLLMRIP----- 192
            |||:..|...|..|       .|..||..:... |||:    :||..|  :..::.:|.|     
Human     6 GLIWASSFFTLSLQKPRLLLFSPSVVHLGVPLSVGVQL----QDVPRGQVVKGSVFLRNPSRNNV 66

  Fly   193 PTSVTGSYKLRVE------------------GFYQNVFG-----------------------GLA 216
            |.|....:.|..|                  |.:|.:.|                       |:.
Human    67 PCSPKVDFTLSSERDFALLSLQVPLKDAKSCGLHQLLRGPEVQLVAHSPWLKDSLSRTTNIQGIN 131

  Fly   217 FLNETRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPITTELKGFDNPVDVYMLDPNRH---ILK 278
            .|      ||.|...:|:|||:|:|..|:.||:|...:..:::...:.:.|.:  .|.|   :.|
Human   132 LL------FSSRRGHLFLQTDQPIYNPGQRVRYRVFALDQKMRPSTDTITVMV--ENSHGLRVRK 188

  Fly   279 RWLSRQSNLGSVSLEYKLSDQPTFGEWTIRV-IAQGQQEES--HFTVEEYYQTRFEVNVTMPAYF 340
            :.:...|::  ...::.:.|....|.|.|.. .:.|.:..|  .|.|::|....|||.:|....:
Human   189 KEVYMPSSI--FQDDFVIPDISEPGTWKISARFSDGLESNSSTQFEVKKYVLPNFEVKITPGKPY 251

  Fly   341 FTTDPFIYGR-------VMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNE--KYRLGRSPLEQT 396
            ..|.|   |.       :.|.:..|.||:|          :.|....:|:|  |....|....||
Human   252 ILTVP---GHLDEMQLDIQARYIYGKPVQG----------VAYVRFGLLDEDGKKTFFRGLESQT 303

  Fly   397 NLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQ 461
            .|.|                      .|....||                          |.|:|
Human   304 KLVN----------------------GQSHISLS--------------------------KAEFQ 320

  Fly   462 DSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATV-----GEKFYDEI 521
            |:                            |.:|.:.:.:|....:.:.|.:     ||....|:
Human   321 DA----------------------------LEKLNMGITDLQGLRLYVAAAIIESPGGEMEEAEL 357

  Fly   522 ISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPIDPNLLRQGL-MEVSGFVES 585
            .|.|.|:..::     :.|..:.:...|..||.....|....|||      ..|: ::||..|.|
Human   358 TSWYFVSSPFS-----LDLSKTKRHLVPGAPFLLQALVREMSGSP------ASGIPVKVSATVSS 411

  Fly   586 RNGGRRDWPAQRLP----MSQQSDGIWEVKIDIRNDLNLDDRPQARDFLNGVQNMRLQANFVDPR 646
            ...         :|    :.|.:||..:|.|.|                            :.| 
Human   412 PGS---------VPEVQDIQQNTDGSGQVSIPI----------------------------IIP- 438

  Fly   647 GERIQTELLLVSHYSPRNQHIKVTTS----------------TEKPVVGEYIIFHIR---TNFYL 692
             :.|....|.||..||.....::|.:                :..|.||:.:..::|   :....
Human   439 -QTISELQLSVSAGSPHPAIARLTVAAPPSGGPGFLSIERPDSRPPRVGDTLNLNLRAVGSGATF 502

  Fly   693 EEFNYLIMSKGVILVNDRE---TITEGIKTIAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPV 754
            ..:.|:|:|:|.|:..:||   |:|    :::|.:...:||....|.:..:.. ..||:||...|
Human   503 SHYYYMILSRGQIVFMNREPKRTLT----SVSVFVDHHLAPSFYFVAFYYHGD-HPVANSLRVDV 562

  Fly   755 N-GISRNNFTVYINNRKA-RTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNE----LTYAKII 813
            . |.......:.::..|. |.||.|::.:..:..:.|.|..:|:|.|.  ||::    |...|:.
Human   563 QAGACEGKLELSVDGAKQYRNGESVKLHLETDSLALVALGALDTALYA--AGSKSHKPLNMGKVF 625

  Fly   814 TKMSNFDEQTNGTYKHIWYSHEGNPDELVYFPASSFGVDANRTFEYSGLIVFTDG---YVPRRQD 875
            ..|:::|                    |...|..  |..|.:.|:.:|| .|:||   .:.|::.
Human   626 EAMNSYD--------------------LGCGPGG--GDSALQVFQAAGL-AFSDGDQWTLSRKRL 667

  Fly   876 TC--------NRTLGFGECLSGRCYR----LEKQCDGLFDCDDGTDEI----NCHAR-------- 916
            :|        .|.:.|.:.::.:..:    ..|:|     |.||...:    :|..|        
Human   668 SCPKEKTTRKKRNVNFQKAINEKLGQYASPTAKRC-----CQDGVTRLPMMRSCEQRAARVQQPD 727

  Fly   917 ---------NDTELLNYRK--------YRFNRVLRHYENV--------------WLWKDVNIGPH 950
                     ...|.|..:.        .|...:|:..:.:              |||:...:   
Human   728 CREPFLSCCQFAESLRKKSRDKGQAGLQRALEILQEEDLIDEDDIPVRSFFPENWLWRVETV--- 789

  Fly   951 GRY-IFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRV 1014
            .|: |..:.:||....|.:...|:|.:||..:.......| .:.|.:::.:|.:.|:.||:.:|.
Human   790 DRFQILTLWLPDSLTTWEIHGLSLSKTKGLCVATPVQLRV-FREFHLHLRLPMSVRRFEQLELRP 853

  Fly  1015 TVFNYM---------ITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPRTSFGEHQFFIYLEAQGT 1070
            .::||:         ::|:|.:.:....           |:.:.             :.:.|...
Human   854 VLYNYLDKNLTVSVHVSPVEGLCLAGGG-----------GLAQQ-------------VLVPAGSA 894

  Fly  1071 TVVYVPVVPQRLGNVDVTLHVATLLGT------DTITRTLHVESDGLPQYRHQSV--LLDLSNRA 1127
            ..|...|||  .....|:|.|.. .|:      |.:::.|.:|.:| ..:|.:.|  |..|.:|.
Human   895 RPVAFSVVP--TAATAVSLKVVA-RGSFEFPVGDAVSKVLQIEKEG-AIHREELVYELNPLDHRG 955

  Fly  1128 YVLEYMHVNVTQTPEIPYQVDRYFV-YGSNKARISVVG----DVVGPIFPTMPVNASSLLSLPME 1187
                       :|.|||...|...: .|...:.:.|..    |.:|......|...:|||.||..
Human   956 -----------RTLEIPGNSDPNMIPDGDFNSYVRVTASDPLDTLGSEGALSPGGVASLLRLPRG 1009

  Fly  1188 SGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYH----MNIGYQRQLSFMRPDGSFSLFRSDW 1248
            .|||.....|..|....|:....|.: ||......|    :..||.|...|.:.|||::.    |
Human  1010 CGEQTMIYLAPTLAASRYLDKTEQWS-TLPPETKDHAVDLIQKGYMRIQQFRKADGSYAA----W 1069

  Fly  1249 NNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRKM- 1312
            .:..||.|||::.|:|...|     :..:......:::...|||..|...|||.:::.:..|.| 
Human  1070 LSRGSSTWLTAFVLKVLSLA-----QEQVGGSPEKLQETSNWLLSQQQADGSFQDLSPVIHRSMQ 1129

  Fly  1313 -NRTNFDKNITLTSHVLIT----LATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQ---- 1368
             .....|:.:.||:.|.|.    ||..:|      .......||..|.|.:...||..:|.    
Human  1130 GGLVGNDETVALTAFVTIALHHGLAVFQD------EGAEPLKQRVEASISKASSFLGEKASAGLL 1188

  Fly  1369 -PFDVAITAYALQLCNSP-----IAEEVFAILRRQARTIGDFMYWG-------NQEIPQP-PRKL 1419
             ....|||||||.|..:|     :|..   .|...|:..||.:|||       |...|.| ||..
Human  1189 GAHAAAITAYALTLTKAPADLRGVAHN---NLMAMAQETGDNLYWGSVTGSQSNAVSPTPAPRNP 1250

  Fly  1420 ENQKWFSLPRLPYEYDSLNIETTAYA---LLVYVARREFFVDPIVRWLNSQRLNDGGWASTQDTS 1481
            .:    .:|:.|    :|.|||||||   ||::..:.| ..|....||..|....||:.|||||.
Human  1251 SD----PMPQAP----ALWIETTAYALLHLLLHEGKAE-MADQAAAWLTRQGSFQGGFRSTQDTV 1306

  Fly  1482 AALKALVEYTVRSRLREVSSLTVEIEASSQGG-KTQTLYIDDTNLAKLQSIEIPDAWGT---IKV 1542
            .||.||..|.:.|...|...|.|.:.::.:.| |:..|.:::..:..|:. |:..:.|:   :||
Human  1307 IALDALSAYWIASHTTEERGLNVTLSSTGRNGFKSHALQLNNRQIRGLEE-ELQFSLGSKINVKV 1370

  Fly  1543 QAKGAG-------YAILQM----------------HVQY----NVDIEKFQ-------TKPPVPA 1573
            .....|       |.:|.|                ||:|    |.|.|.::       ..|..|.
Human  1371 GGNSKGTLKVLRTYNVLDMKNTTCQDLQIEVTVKGHVEYTMEANEDYEDYEYDELPAKDDPDAPL 1435

  Fly  1574 FGLHTKAIFHGR--------------NQSHISYVACQNWINQNESERSGMAVLDVAIPTGYWIQQ 1624
            ..:....:|.||              .:|.:.|..| .|.| .:...||||:.||.:.:|:...:
Human  1436 QPVTPLQLFEGRRNRRRREAPKVVEEQESRVHYTVC-IWRN-GKVGLSGMAIADVTLLSGFHALR 1498

  Fly  1625 QKLDTYV-LSNRVRNLRRARYLERK---IVFYFDYLDHEDICVNFTIERWYPVANMSRYLPVRIY 1685
            ..|:... ||:|.     ..:.|.:   ::.|||.:.....||.|...:..|| .:.:.....:|
Human  1499 ADLEKLTSLSDRY-----VSHFETEGPHVLLYFDSVPTSRECVGFEAVQEVPV-GLVQPASATLY 1557

  Fly  1686 DYYAPERFNESIFDALPT---YLLNICEV----CGSSQCP 1718
            |||.||| ..|:|...|:   .|..:|..    |...:||
Human  1558 DYYNPER-RCSVFYGAPSKSRLLATLCSAEVCQCAEGKCP 1596

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 25/105 (24%)
A2M_N_2 669..799 CDD:285005 33/153 (22%)
LDLa 886..913 CDD:238060 5/34 (15%)
A2M 940..1030 CDD:278630 23/99 (23%)
ISOPREN_C2_like 1177..1490 CDD:298658 105/343 (31%)
A2M_comp 1226..1492 CDD:284982 91/292 (31%)
A2M_recep 1607..1695 CDD:284981 27/91 (30%)
C4BNP_001002029.3 A2M_N 141..233 CDD:280081 22/95 (23%)
A2M_N_2 478..610 CDD:285005 32/136 (24%)
ANATO 686..750 CDD:237984 9/68 (13%)
A2M 782..869 CDD:278630 21/90 (23%)
complement_C3_C4_C5 996..1315 CDD:239226 106/346 (31%)
A2M_comp 1051..1317 CDD:284982 91/292 (31%)
A2M_recep 1481..1570 CDD:284981 28/95 (29%)
NTR_complement_C4 1588..1742 CDD:239639 3/9 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
54.880

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